Chemoselective umpolung of thiols to episulfoniums for cysteine bioconjugation [0.03%]
巯基的化学选择性极性反转为环氧硫鎓离子，用于半胱氨酸生物偶联反应
Philipp Hartmann,Kostiantyn Bohdan,Moritz Hommrich et al.
Philipp Hartmann et al.
Cysteine conjugation is an important tool in protein research and relies on fast, mild and chemoselective reactions. Cysteinyl thiols can either be modified with prefunctionalized electrophiles, or converted into electrophiles themselves fo...
Ciceron Ayala-Orozco,Diego Galvez-Aranda,Arnoldo Corona et al.
Ciceron Ayala-Orozco et al.
Through the actuation of vibronic modes in cell-membrane-associated aminocyanines, using near-infrared light, a distinct type of molecular mechanical action can be exploited to rapidly kill cells by necrosis. Vibronic-driven action (VDA) is...
Quintashia D Wilson,Ellen M Sletten
Quintashia D Wilson
Tuan M Nguyen,Vedagopuram Sreekanth,Arghya Deb et al.
Tuan M Nguyen et al.
Proteolysis-targeting chimeras (PROTACs) are molecules that induce proximity between target proteins and E3 ligases triggering target protein degradation. Pomalidomide, a widely used E3 ligase recruiter in PROTACs, can independently degrade...
Julia Dshemuchadse
Julia Dshemuchadse
Author Correction: Structural resolution of a small organic molecule by serial X-ray free-electron laser and electron crystallography [0.03%]
作者更正：通过序列X射线自由电子激光和电子衍射解析小有机分子结构
Kiyofumi Takaba,Saori Maki-Yonekura,Ichiro Inoue et al.
Kiyofumi Takaba et al.
Published Erratum
Nature chemistry. 2023 Dec 13. DOI:10.1038/s41557-023-01406-8 2023
Click processes orthogonal to CuAAC and SuFEx forge selectively modifiable fluorescent linkers [0.03%]
基于点击化学的可选择修饰的荧光交联剂及其应用
Paulo H S Paioti,Katherine E Lounsbury,Filippo Romiti et al.
Paulo H S Paioti et al.
The appeal of catalytic click chemistry is largely due to the copper-catalysed azide-alkyne cycloaddition (CuAAC) process, which is orthogonal to the more recently introduced sulfur-fluoride exchange (SuFEx). However, the triazole rings gen...
Modular α-tertiary amino ester synthesis through cobalt-catalysed asymmetric aza-Barbier reaction [0.03%]
钴催化不对称氮化巴布科克反应实现模块化α-季胺酯合成
Xianqing Wu,Hanyu Xia,Chenyang Gao et al.
Xianqing Wu et al.
Unnatural chiral α-tertiary amino acids containing two different carbon-based substituents at the α-carbon centre are widespread in biologically active molecules. This sterically rigid scaffold is becoming a growing research interest in d...
Electrochemical labelling of hydroxyindoles with chemoselectivity for site-specific protein bioconjugation [0.03%]
具有化学选择性的电化学标记羟基吲哚用于蛋白质定点偶联
Conor Loynd,Soumya Jyoti Singha Roy,Vincent J Ovalle et al.
Conor Loynd et al.
Electrochemistry has recently emerged as a powerful approach in small-molecule synthesis owing to its numerous attractive features, including precise control over the fundamental reaction parameters, mild reaction conditions and innate scal...