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Click processes orthogonal to CuAAC and SuFEx forge selectively modifiable fluorescent linkers

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The appeal of catalytic click chemistry is largely due to the copper-catalysed azide-alkyne cycloaddition (CuAAC) process, which is orthogonal to the more recently introduced sulfur-fluoride exchange (SuFEx). However, the triazole rings generated by CuAAC are ... ...