PKC-PKD-NFκB signaling induces cardiomyocyte t-tubule loss via a conserved macropinocytic mechanism [0.03%]
PKC-PKD-NFκB信号通过保守的巨胞饮机制诱导心肌细胞t小管丢失
A Martinez-Vilchez,A-K M Pfeuffer,J Weßolowski et al.
A Martinez-Vilchez et al.
Aims: Deterioration of transverse-axial tubules (t-tubules) contributes to insufficient excitation-contraction coupling in heart failure, yet the key signals and mechanisms remain unclear. Here we aimed to identify the si...
Deletion of endothelial SOX9 reverses aging-induced cardiac dysfunction [0.03%]
删除内皮SOX9可逆转衰老诱导的心功能障碍
Felix A Trogisch,Manuela Fuhrmann,Aya Abouissa et al.
Felix A Trogisch et al.
Multiple 4q25 risk variants impair calcium homeostasis and compromise left atrial function [0.03%]
多个4q25风险变异体可干扰钙稳态并损害左心房功能
Verónica Jiménez-Sábado,Carmen Tarifa,Oliver B Vad et al.
Verónica Jiménez-Sábado et al.
Aims: Single-nucleotide polymorphisms (SNPs) from distinct linkage blocks in the chromosomal region 4q25 (rs1448818, rs2200733 and rs10033464) are associated with increased risk of atrial fibrillation (AF), but their impa...
Urea cycle fumarate limits fibrosis post-MI by reducing fibroblast mitochondrial ATP production [0.03%]
尿素循环延胡索酸通过减少成纤维细胞线粒体ATP产生限制MI后肝纤维化进展
Jing Zhao,Yating Ruan,Yongjian Chen et al.
Jing Zhao et al.
Aims: Cardiac fibrosis, a common pathological outcome of various heart diseases including myocardial infarction (MI), is primarily driven by the activation and trans-differentiation of cardiac fibroblasts which demand sub...
Ventricular fibrillation dynamics reveal regional asymmetry in resilience to cardiac arrest and predict clinical outcome [0.03%]
心室内纤维化动力学揭示了心脏对心脏骤停恢复力的区域不对称性并预测临床结果
Andrés Redondo-Rodríguez,Jorge G Quintanilla,Álvaro Macías et al.
Andrés Redondo-Rodríguez et al.
Aims: Ventricular fibrillation (VF) is the leading cause of sudden cardiac death. Nevertheless, the mechanisms underlying VF dynamics in structurally normal hearts and infarct-related substrates remain incompletely unders...
A titin truncating variant linked to atrial fibrillation increases atrial profibrotic signalling and cholinergic sensitivity [0.03%]
与心房颤动相关的一种肌联蛋白截短变异体可增加心房促纤维化信号转导和胆碱能敏感性
Max J Cumberland,Albert Dasí,Naeramit Sontayananon et al.
Max J Cumberland et al.
Aims: Titin truncating variants (TTNtv) are a major genetic cause of dilated cardiomyopathy (DCM), accounting for approximately 25% of familial cases. Atrial fibrillation (AF) frequently occurs in DCM patients carrying TT...
Targeting RUNX1 protects against diastolic dysfunction in a two-hit mouse model of heart failure with preserved ejection fraction [0.03%]
靶向RUNX1可在两种损伤诱导的射血分数保留型心力衰竭小鼠模型中保护心脏舒张功能
Ali Ali Mohamed Elbassioni,Anmar A Raheem,Jian Song et al.
Ali Ali Mohamed Elbassioni et al.
Aims: Heart failure with preserved ejection fraction (HFpEF) continues to increase in prevalence and has limited treatment options. HFpEF is a systemic condition with a broad phenotype including diastolic dysfunction, pul...
Glomus cell heterogeneity underpins distinct carotid body chemoreflex pathways: implications for hypertension [0.03%]
颈动脉体中 GLUT1 阳性嗜铬细胞异质性及其对高血压的影响
Xin Shen,Audry G Pauza,Olivia M S Gold et al.
Xin Shen et al.
Aims: The carotid body (CB) is a multimodal chemosensory organ, yet how it encodes differential external stimuli to drive distinct peripheral chemoreflex responses remains unclear. This study aimed to define differences i...
Akshay Ware,Sameen Fatima,Wesley T Abplanalp
Akshay Ware
Identification of unannotated microproteins involved in endothelial cell homeostasis, dysfunction and vascular disease [0.03%]
参与内皮细胞稳态、功能障碍和血管疾病的未注释微蛋白的鉴定
Mauro Siragusa,Johannes Graumann,Carsten Kuenne et al.
Mauro Siragusa et al.
Aims: Microproteins (miPs) translated from small open reading frames (smORFs) are crucial regulators of cell function. However, the expression and function of miPs in endothelial cells, and alterations in miP expression l...