The loss of microRNA-26b promotes aortic calcification through the regulation of cell-specific target genes [0.03%]
microRNA-26b丢失通过调节特定细胞靶基因促进主动脉钙化
Diana Luna Buitrago,Eva Jover,Eleonora Mameli et al.
Diana Luna Buitrago et al.
Aims: Vascular calcification is the abnormal deposition of calcium phosphates within blood vessels. This condition is significantly associated with the development of cardiovascular disease, yet the underlying mechanisms ...
Mapping the histopathology of aortic abdominal aneurysms: a step toward precision medicine [0.03%]
主动脉腹侧动脉瘤的病理图谱绘制：精准医疗的一步
Tomasz P Mikolajczyk,Piotr Szczepaniak,Tomasz J Guzik
Tomasz P Mikolajczyk
S913 phosphorylation of Ulk1 protects the heart from aging through inhibition of cardiac senescence [0.03%]
S913 磷酸化Ulk1通过抑制心肌细胞衰老保护心脏免受衰老的影响
Peiyong Zhai,Eun-Ah Sung,Koichiro Takayama et al.
Peiyong Zhai et al.
Aims: We have previously shown that prevention of GSK-3β inactivation with GSK-3β (S9A), stimulates autophagy through phosphorylation of Ulk1 at Ser913. In the current study, we investigated whether cardiac aging is acc...
Early awakenings New insights into graft-host coupling in cardiac cell therapy [0.03%]
早期觉醒心脏细胞治疗中供体-宿主相互作用的新见解
Filippo Perbellini,Charles E Murry,Danny El-Nachef
Filippo Perbellini
Ageing-associated endothelial decorin induction and the impact of non-glycanated decorin on cardiac inflammation [0.03%]
衰老相关内皮层 decorin 诱导及非糖基化 decorin 对心脏炎症的影响
Guillermo Luxán,Timm Winkelmeier,Colin Bodemer et al.
Guillermo Luxán et al.
Aims: Cardiovascular disease is the leading cause of death in the European Union and aging is one of its major risk factors resulting in the progressive deterioration of the cardiac structures and function. Here, we have ...
PCSK9 reloaded: Sirtuin-1 as a post-translational checkpoint for LDL-C control [0.03%]
PCSK9重载：Sirtuin-1作为LDL-C控制的翻译后检查点
Angela Pirillo,Alberico L Catapano
Angela Pirillo
Let food be thy medicine: anti-inflammatory diets and the hidden properties of coronary plaque [0.03%]
药食同源：抗炎饮食与冠脉斑块的隐蔽属性
Eiry Jones,Tomasz J Guzik
Eiry Jones
Prevalence of hypertension in Africa in the last two decades: Systematic review and meta-analysis [0.03%]
撒哈拉以南非洲地区过去20年高血压患病率的系统评价和meta分析
Paul Olowoyo,Akinkunmi Paul Okekunle,Osahon Jeffery Asowata et al.
Paul Olowoyo et al.
Aims: Despite being the most common cardiovascular risk factor, the actual burden of hypertension is poorly characterized in Africa. We meta-analyzed the most extensive pooled data to determine the overall prevalence of h...
Right stellate ganglion stimulation modulates arrhythmogenesis in acute left lateral ventricular ischemia [0.03%]
右侧星状神经节刺激可调节急性左侧心室缺血的异位冲动形成和心脏复极离散度增加
Joseph E Hadaya,Bastiaan J D Boukens,Michiel J Janse et al.
Joseph E Hadaya et al.
Aim: Acute myocardial ischemia causes fatal arrhythmias as result of a flow of 'injury current'. Left stellate ganglion stimulation (LSGS) modulates the injury current and is arrhythmogenic during left anterior ventricula...
Sirtuin-1 directly binds and deacetylates hepatic PCSK9 thereby promoting the inhibition of LDL receptor degradation [0.03%]
Sirtuin-1直接结合并去乙酰化肝PCSK9从而促进LDL受体降解的抑制作用
Srividya Velagapudi,Melroy X Miranda,Priyanka Adla et al.
Srividya Velagapudi et al.
Aims: Low-density lipoprotein (LDL)-cholesterol is causally involved in atherosclerotic cardiovascular disease (ASCVD) pathogenesis. Pharmacological activation of the intracellular NAD + -dependent deacetylase Sirtuin-1 (...