Defining the safety belt for stroke thrombolysis: Preclinical validation of citPA5 across species and hemorrhagic scenarios [0.03%]
定义卒中溶栓安全带：跨物种和出血场景的citPA5前期验证研究
Longguang Jiang,Cai Yuan,Mingdong Huang
Longguang Jiang
Chronotherapy as a novel strategy to limit anthracycline-induced cardiotoxicity [0.03%]
chronotherapy在限制蒽环类药物引起的心脏毒性中的新策略研究
Ilse R Kelters,Markella I Printezi,Annabelle Ballesta et al.
Ilse R Kelters et al.
Anthracycline cardiotoxicity is a severe chemotherapeutic side effect that can lead to heart failure in cancer patients and survivors. Chronomodulated chemotherapy is a promising preventive strategy that encompasses the adjustment of anthra...
Sympathovagal crosstalk: Y2-receptor blockade enhances vagal effects which in turn Reduce NPY levels via muscarinic receptor activation [0.03%]
交感迷走神经交互作用：Y2受体阻断增强迷走神经效应，后者通过激活毒蕈碱型乙酰胆碱受体降低NPY水平
Neil R Jani,Valerie Y H van Weperen,Thamali Ayagama et al.
Neil R Jani et al.
Aims: Ventricular arrhythmias are associated with sympathoexcitation and increased co-transmitter neuropeptide Y (NPY) levels. Vagal nerve stimulation (VNS) has been reported to decrease release of norepinephrine, while N...
Global, regional, and national burden of aortic aneurysm in the elderly from 1990 to 2021, and projections to 2050: a systematic analysis based on the 2021 Global Burden of Disease Study [0.03%]
1990至2021年全球、区域和国家老年人主动脉瘤负担及2050年疾病负担预测：基于2021年全球疾病负担研究的系统分析
Cong Hu,Shuxiong Nong,Qi Zhang et al.
Cong Hu et al.
CTLA-4-Ig therapy preserves cardiac function following myocardial infarction with reperfusion [0.03%]
CTLA-4 Ig治疗能保护再灌注心肌梗死后的心脏功能
Jonathan Noonan,Shania A Prijaya,Laura A Bienvenu et al.
Jonathan Noonan et al.
Aims: T cells drive adverse cardiac inflammation and ischemia-reperfusion injury following myocardial infarction (MI). Here, we aimed to test the extent to which T cell inhibition protected cardiac function following MI i...
CTLA-4-Ig therapy preserves cardiac function following myocardial infarction with reperfusion [0.03%]
CTLA-4-Ig治疗可保护再灌注心肌梗死后的心脏功能
Jonathan Noonan,Shania A Prijaya,Laura A Bienvenu et al.
Jonathan Noonan et al.
Aims: T cells drive adverse cardiac inflammation and ischemia-reperfusion injury following myocardial infarction (MI). Here, we aimed to test the extent to which T cell inhibition protected cardiac function following MI i...
RRAD-reduction reveals efficacy of targeting L-type calcium channel regulation for treatment of heart failure [0.03%]
RRAD降低揭示了靶向L型钙通道调节治疗心力衰竭的疗效
Garrett Elmore,Sarisha S Lohano,Nicholas M McVay et al.
Garrett Elmore et al.
Aims: Heart failure with reduced ejection fraction (HFrEF) is a major health problem. Increasing L-type calcium channel (LTCC) activity deteriorates heart function; however, myocardial RRAD knockout (cRADΔ/Δ) instills t...
Decor(at)i(o)n-less is more? [0.03%]
去装饰化更好吗？
Felix A Trogisch,Joerg Heineke
Felix A Trogisch
The new generation of small interfering RNAs directed against apoprotein(a): focus on the safety and efficacy of zerlasiran and lepodisiran [0.03%]
新一代针对载脂蛋白(a)的小干扰RNA：聚焦于zerlasiran和lepodisiran的安全性和有效性
Andrea Baragetti,Giuseppe Danilo Norata
Andrea Baragetti
Precision medicine requires precision proteomics: Discordance between proteomic and clinical assays in UK Biobank [0.03%]
精准医学需要精准蛋白质组学：英国生物银行中蛋白质组学和临床检测结果不一致导致的精确性问题
Bhawana Singh,Ioanna Tzoulaki,Manuel Mayr
Bhawana Singh