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Proteomic profiling reveals a higher presence of glycolytic enzymes in human atherosclerotic lesions with unfavourable histological characteristics [0.03%] 蛋白组学分析显示在具有不利组织病理特征的人动脉粥样硬化斑块中糖酵解酶含量更高
Kaylin C A Palm,Xiaoke Yin,Ferheen Baig et al. Kaylin C A Palm et al.
Aims: Molecular characterization of vulnerable atherosclerotic plaques often relies on transcriptomic data. However, RNA expression may not consistently align with protein expression. The proteomic landscape linked to pla...
Jort S A van der Geest,Teun P de Boer,Cesare M Terracciano et al. Jort S A van der Geest et al.
Cardiovascular disease remains a persistent global health burden, underscoring the necessity for effective therapeutic strategies. Despite significant advances, the ability to mechanistically study human disease and predict clinical outcome...
RNA interference versus antibody-based PCSK9 inhibition for the prevention of cardiovascular disease: A drug-target Mendelian randomization study [0.03%] 针对心血管疾病的RNA干扰与基于抗体的PCSK9抑制：药物-靶标孟德尔随机化研究
Eloi Gagnon,Dipender Gill,Jérôme Bourgault et al. Eloi Gagnon et al.
Aims: RNA interference therapies targeting liver expression of the gene proprotein convertase subtilisin/kexin type 9 (PCSK9) lower low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apoB) levels. As oppose...
Emiel P C van der Vorst,Giuseppe Lembo Emiel P C van der Vorst
Marcos Gonzalez,Quang-Kim Tran Marcos Gonzalez
Abdominal aortic aneurysm histomorphology shows different inflammatory aspects among patients and is not associated with classic risk factors - the HistAAA study [0.03%] 腹主动脉瘤的组织形态在不同患者中表现出不同的炎症特征，并且与经典危险因素无关——HistAAA研究
Maja Carina Nackenhorst,Felix Menges,Bianca Bohmann et al. Maja Carina Nackenhorst et al.
Aims: Abdominal aortic aneurysm (AAA) treatment is upon a diameter threshold. Attempts for medical growth abrogation have failed thus far. This study aims to elucidate the heterogeneity of AAA histomorphology in correlati...
Distinct intracellular spatiotemporal expression of Calmodulin genes underlies functional diversity of CaM-dependent signaling in cardiac myocytes [0.03%] 心肌细胞中钙调素基因的独特的亚细胞时空表达决定了功能多样化的CaM依赖性信号转导过程
Vladimir Bogdanov,Juan I E Mariangelo,Andrew M Soltisz et al. Vladimir Bogdanov et al.
Aims: This study aims to resolve the mechanisms underlying Calmodulin (CaM)'s signaling diversity by investigating whether the three CaM genes-Calm1, Calm2, and Calm3-play distinct or redundant roles in cardiac myocytes, ...
Identification of pulmonary artery stiffening due to left heart disease by ultrasonography [0.03%] 左心病引起的肺动脉硬化超声识别
Mariya M Kucherenko,Marian Kukucka,Pengchao Sang et al. Mariya M Kucherenko et al.
Aims: Pulmonary hypertension (PH) is a common complication of left heart disease (LHD) that leads to right heart failure and death. Pulmonary artery (PA) stiffening has recently emerged as an important diagnostic and prog...
A new protein isoform encoded by human circular RNA circSLC8a1 contributes to cardiac remodeling [0.03%] 由人类环形RNA circSLC8a1编码的一种新的蛋白质异构体会促进心脏重塑
Feiya Li,William W Du,Xiangmin Li et al. Feiya Li et al.
Aims: Circular RNA circSLC8a1 has been previously suggested to possess translation potential, but experimental evidence supporting this notion has been lacking. We aim to understand the functions of circSLC8a1 and its tra...
Sex and sex hormonal regulation of the atrial inward rectifier potassium current (IK1): insights into potential pro-arrhythmic mechanisms [0.03%] 性与性激素对房室钾电流(IK1)的调节作用及潜在促心律失常机制研究
Lucilla Giammarino,Lluis Matas,Nicolò Alerni et al. Lucilla Giammarino et al.
Aims: Pronounced sex-differences are known in the incidence of atrial fibrillation (AF). In this study, we aimed to investigate the atrial electrophysiological properties that may underlie sex-differences in AF incidence ...