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A titin truncating variant linked to atrial fibrillation increases atrial profibrotic signalling and cholinergic sensitivity

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Aims: Titin truncating variants (TTNtv) are a major genetic cause of dilated cardiomyopathy (DCM), accounting for approximately 25% of familial cases. Atrial fibrillation (AF) frequently occurs in DCM patients carrying TTNtv and ... ...