Iron deficiency in myocardial ischaemia: molecular mechanisms and therapeutic perspectives [0.03%]
缺铁在心肌缺血中的分子机制和治疗前景
Francesco Corradi,Gabriele Masini,Tonino Bucciarelli et al.
Francesco Corradi et al.
Systemic iron deficiency (SID), even in the absence of anaemia, worsens the prognosis and increases mortality in heart failure (HF). Recent clinical-epidemiological studies, however, have shown that a myocardial iron deficiency (MID) is fre...
Cardiomyocyte and endothelial cells play distinct roles in the tumour necrosis factor (TNF)-dependent atrial responses and increased atrial fibrillation vulnerability induced by endurance exercise training in mice [0.03%]
心肌细胞和内皮细胞在肿瘤坏死因子依赖的房颤易感性增加中的不同作用
Robert Lakin,Nazari Polidovitch,Sibao Yang et al.
Robert Lakin et al.
Aims: Endurance exercise is associated with an increased risk of atrial fibrillation (AF). We previously established that adverse atrial remodelling and AF susceptibility induced by intense exercise in mice require the me...
Predictive metabolites for incident myocardial infarction: a two-step meta-analysis of individual patient data from six cohorts comprising 7897 individuals from the COnsortium of METabolomics Studies [0.03%]
预测性代谢产物用于预测性心肌梗死：来自COnsortium of METabolomics Studies的六个队列包含的7897名个体的两步元分析的个体患者数据
Ana Nogal,Taryn Alkis,Yura Lee et al.
Ana Nogal et al.
Aims: Myocardial infarction (MI) is a major cause of death and disability worldwide. Most metabolomics studies investigating metabolites predicting MI are limited by the participant number and/or the demographic diversity...
Metabolic targeting of platelets to combat thrombosis: dawn of a new paradigm? [0.03%]
针对血小板代谢治疗血栓：新范式的黎明？
Gagan D Flora,Manasa K Nayak,Madankumar Ghatge et al.
Gagan D Flora et al.
Current antithrombotic therapies used in clinical settings target either the coagulation pathways or platelet activation receptors (P2Y12 or GPIIb/IIIa), as well as the cyclooxygenase (COX) enzyme through aspirin. However, they are associat...
Atrial fibrillation-associated electrical remodelling in human induced pluripotent stem cell-derived atrial cardiomyocytes: a novel pathway for antiarrhythmic therapy development [0.03%]
人诱导多能干细胞源心房细胞重构电生理在心房颤动研究中的应用及抗心律失常治疗的新途径
Fitzwilliam Seibertz,Tony Rubio,Robin Springer et al.
Fitzwilliam Seibertz et al.
Aims: Atrial fibrillation (AF) is associated with tachycardia-induced cellular electrophysiology alterations which promote AF chronification and treatment resistance. Development of novel antiarrhythmic therapies is hampe...
Can a genetic mutation associated with glycosuria teach us about the action of sodium-glucose cotransporter-2 inhibitors? [0.03%]
一个与尿糖有关的基因突变能否教会我们钠-葡萄糖共转运体2抑制剂的作用机制？
Jonathan Golledge
Jonathan Golledge
Single-nuclear transcriptome profiling identifies persistent fibroblast activation in hypertrophic and failing human hearts of patients with longstanding disease [0.03%]
单核转录组分析识别了长期患病患者的心脏肥大和衰竭的成纤维细胞激活现象
Badder Kattih,Felicitas Boeckling,Mariana Shumliakivska et al.
Badder Kattih et al.
Aims: Cardiac fibrosis drives the progression of heart failure in ischaemic and hypertrophic cardiomyopathy. Therefore, the development of specific anti-fibrotic treatment regimens to counteract cardiac fibrosis is of hig...
PDE4D mediates impaired β-adrenergic receptor signalling in the sinoatrial node in mice with hypertensive heart disease [0.03%]
PDE4D介导高血压性心脏病小鼠窦房结β肾上腺素受体信号转导障碍
Tristan W Dorey,Megan D McRae,Darrell D Belke et al.
Tristan W Dorey et al.
Aims: The sympathetic nervous system increases HR by activating β-adrenergic receptors (β-ARs) and increasing cAMP in sinoatrial node (SAN) myocytes while phosphodiesterases (PDEs) degrade cAMP. Chronotropic incompetenc...
Stroke risk management in carotid atherosclerotic disease: A Clinical Consensus Statement of the ESC Council on Stroke and the ESC Working Group on Aorta and Peripheral Vascular Diseases [0.03%]
外周血管疾病的欧洲心脏病学会脑卒中理事会联合共识声明：颈动脉粥样硬化疾病中的卒中风险管控
Piotr Musialek,Leo H Bonati,Richard Bulbulia et al.
Piotr Musialek et al.
Carotid atherosclerotic disease continues to be an important cause of stroke, often disabling or fatal. Such strokes could be largely prevented through optimal medical therapy and carotid revascularization. Advancements in discovery researc...
Genetic inactivation of β-catenin is salubrious, whereas its activation is deleterious in desmoplakin cardiomyopathy [0.03%]
遗传失活有益，而激活有害：DP 相关性心肌病小鼠模型中的β-连环蛋白悖论现象研究
Melis Olcum,Siyang Fan,Leila Rouhi et al.
Melis Olcum et al.
Aims: Mutations in the DSP gene encoding desmoplakin, a constituent of the desmosomes at the intercalated discs (IDs), cause a phenotype that spans arrhythmogenic cardiomyopathy (ACM) and dilated cardiomyopathy. It is typ...