Influence of angiotensin II on the gut microbiome: Modest effects in comparison to experimental factors [0.03%]
血管紧张素II对肠道微生物组的影响：与实验因素相比影响较小
Rikeish R Muralitharan,Michael E Nakai,Matthew Snelson et al.
Rikeish R Muralitharan et al.
Introduction: Animal models are regularly used to test the role of the gut microbiome in hypertension. Small-scale pre-clinical studies have investigated changes to the gut microbiome in the angiotensin II hypertensive mo...
Stem cell factor and cKIT modulate endothelial glycolysis in hypoxia [0.03%]
干细胞因子和c-Kit在缺氧条件下调节内皮细胞糖酵解
Hayoung Jeong,Ryul-I Kim,Hyunwoo Koo et al.
Hayoung Jeong et al.
Aims: In hypoxia, endothelial cells (ECs) proliferate, migrate, and form new vasculature in a process called angiogenesis. Recent studies have suggested that ECs rely on glycolysis to meet metabolic needs for angiogenesis...
BMP9 is a key player in endothelial identity and its loss is sufficient to induce arteriovenous malformations [0.03%]
BMP9在内皮身份维持中起关键作用及其丢失足以诱导动静脉畸形
Agnes Desroches-Castan,Dzenis Koca,Hequn Liu et al.
Agnes Desroches-Castan et al.
Aims: BMP9 is a high affinity ligand of ALK1 and endoglin receptors that are mutated in the rare genetic vascular disorder hereditary hemorrhagic telangiectasia (HHT). We have previously shown that loss of Bmp9 in the 129...
Four-week inhibition of the renin-angiotensin system in spontaneously hypertensive rats results in persistently lower blood pressure with reduced kidney renin and changes in expression of relevant gene networks [0.03%]
四周的肾素血管紧张素系统抑制可持久降低自发性高血压大鼠血压，减少肾脏中肾素水平并改变相关基因表达网络
Sean G Byars,Priscilla R Prestes,Varaporn Suphapimol et al.
Sean G Byars et al.
Aims: Prevention of human hypertension is an important challenge and has been achieved in experimental models. Brief treatment with renin-angiotensin system (RAS) inhibitors permanently reduces the genetic hypertension of...
Persistent increase of cardiovascular and cerebrovascular events in COVID-19 patients: a 3-year population-based analysis [0.03%]
基于人群的分析：COVID-19患者心血管和脑血管事件持续增加——一项为期三年的研究
Allegra Battistoni,Massimo Volpe,Carmine Morisco et al.
Allegra Battistoni et al.
Aims: We evaluated the incidence and relative risk of major post-acute cardiovascular consequences of SARS-CoV-2 infection in a large real-world population from a primary care database in a region at moderate cardiovascul...
Small nucleolar RNA host gene 18 controls vascular smooth muscle cell contractile phenotype and neointimal hyperplasia [0.03%]
血管平滑肌细胞收缩表型和内膜增生调控基因18的研究
Kaiyuan Niu,Chengxin Zhang,Mei Yang et al.
Kaiyuan Niu et al.
Aims: Long non-coding RNA (LncRNA) small nucleolar RNA host gene 18 (SNHG18) has been widely implicated in cancers. However, little is known about its functional involvement in vascular diseases. Herein, we attempted to e...
The dual effects of miR-222 in cardiac hypertrophy: bridging pathological and physiological paradigms [0.03%]
miR-222在心脏肥大中的双重作用：连接病理和生理范式
Despoina Kesidou,Abdelaziz Beqqali,Andrew H Baker
Despoina Kesidou
Alberto Preda,Fabrizio Montecucco,Federico Carbone et al.
Alberto Preda et al.
An increasing number of individuals are at high risk of type 2 diabetes (T2D) and its cardiovascular complications, including heart failure (HF), chronic kidney disease (CKD), and eventually premature death. The sodium-glucose co-transporte...
Smooth muscle cell-specific matrix metalloproteinase 3 deletion reduces osteogenic transformation and medial artery calcification [0.03%]
平滑肌细胞特异性基质金属蛋白酶3的缺失可降低成骨转化和中膜动脉钙化
Yangzhouyun Xie,Tonghui Lin,Ying Jin et al.
Yangzhouyun Xie et al.
Aims: Vascular calcification is highly prevalent in atherosclerosis, diabetes, and chronic kidney disease. It is associated with increased morbidity and mortality in patients with cardiovascular disease. Matrix metallopro...
The electrophysiologic effects of KCNQ1 extend beyond expression of IKs: evidence from genetic and pharmacologic block [0.03%]
KCNQ1的电生理效应超出了IKs的表达：来自遗传和药理阻断的证据
Yuko Wada,Lili Wang,Lynn D Hall et al.
Yuko Wada et al.
Aims: While variants in KCNQ1 are the commonest cause of the congenital long QT syndrome, we and others find only a small IKs in cardiomyocytes from human-induced pluripotent stem cells (iPSC-CMs) or human ventricular myo...