Interleukin-1 receptor accessory protein blockade limits the development of atherosclerosis and reduces plaque inflammation [0.03%]
interleukin-1受体辅佐蛋白阻断限制动脉粥样硬化的发展并减少斑块炎症
Megan Mulholland,Marie A C Depuydt,Gabriel Jakobsson et al.
Megan Mulholland et al.
Aims: The interleukin-1 receptor accessory protein (IL1RAP) is a co-receptor required for signalling through the IL-1, IL-33, and IL-36 receptors. Using a novel anti-IL1RAP-blocking antibody, we investigated the role of I...
Can another lipid, sphingosine-1-phosphate, treat atherosclerosis? [0.03%]
一种名为鞘氨醇-1-磷酸的脂质能治疗动脉粥样硬化吗？
Waqas Younis,Ira J Goldberg
Waqas Younis
Simon Tual-Chalot,Konstantinos Stellos
Simon Tual-Chalot
Reverse cardio-oncology: is heart failure-mediated gut dysbiosis the mechanistic driver of colorectal cancer progression? [0.03%]
逆向心癌学：肠道微生态失衡介导的心力衰竭是否是结直肠癌进展的机制驱动因素？
Ashraf Yusuf Rangrez,Norbert Frey
Ashraf Yusuf Rangrez
Shanli Chen,Sudan Fang,Yang Zhou et al.
Shanli Chen et al.
Aims: Alteplase is a cornerstone thrombolytic agent in clinical practice, but presents a potential bleeding risk. Stroke patients need pre-screening to exclude hemorrhagic stroke before using Alteplase. In this study, we ...
Woan Ting Tay,Yibin Wang
Woan Ting Tay
Lactiplantibacillus plantarum strains KABP011, KABP012, and KABP013 modulate bile acids and cholesterol metabolism in humans [0.03%]
植物乳杆菌KABP011、KABP012和KABP013株调节人体胆汁酸和胆固醇代谢
Teresa Padro,Victoria Santisteban,Pol Huedo et al.
Teresa Padro et al.
Aims: Probiotics with high bile salt hydrolase (BSH) activity have shown to promote cardiovascular health. However, their mechanism(s) of action remain poorly understood. Here, we performed a pilot exploratory study to in...
Inhibition of oxidized low-density lipoprotein with orticumab inhibits coronary inflammation and reduces residual inflammatory risk in psoriasis: a pilot randomized, double-blind placebo-controlled trial [0.03%]
或西木单抗抑制氧化低密度脂蛋白在银屑病患者中可抑制冠状动脉炎症并降低残余炎症风险：一项试点随机、双盲安慰剂对照试验
Christopher J Farina,Michael H Davidson,Prediman K Shah et al.
Christopher J Farina et al.
Randomized Controlled Trial
Cardiovascular research. 2024 May 29;120(7):678-680. DOI:10.1093/cvr/cvae057 2024