New insight into air pollution-related cardiovascular disease: an adverse outcome pathway framework of PM2.5-associated vascular calcification [0.03%]
大气污染相关心血管疾病研究新视野——PM₂·₅致血管钙化的不良结局通路框架解读
Ruiyang Ding,Linyuan Huang,Kanglin Yan et al.
Ruiyang Ding et al.
Despite the air quality has been generally improved in recent years, ambient fine particulate matter (PM2.5), a major contributor to air pollution, remains one of the major threats to public health. Vascular calcification is a systematic pa...
The proprotein convertase FURIN is a novel aneurysm predisposition gene impairing TGF-β signaling [0.03%]
丝裂酶活化蛋白激酶激活的furin是新的动脉瘤易感基因并可抑制TGF-β信号通路
Zongsheng He,Arne S IJpma,Dianne Vreeken et al.
Zongsheng He et al.
Aim: Aortic aneurysms (AA) frequently involve dysregulation of transforming growth factor β (TGF-β)-signaling in the aorta. Here, FURIN was tested as aneurysm predisposition gene given its role as proprotein convertase ...
The epigenetic legacy of renin-angiotensin system inhibition in preventing hypertension [0.03%]
肾素血管紧张素系统抑制的表观遗传学遗绪在预防高血压中的作用
Ryszard Nosalski,Matteo Lemoli
Ryszard Nosalski
Matrix metalloproteinase-3 joins a growing list of proteases that regulate vascular calcification [0.03%]
基质金属蛋白酶-3加入调控血管钙化的蛋白酶大家庭
Cecilia Maria Giachelli,Maristella Donato,Marta Scatena
Cecilia Maria Giachelli
Interactions between KCNQ1 and KCNH2 may modulate the long QT type 1 phenotype [0.03%]
KCNQ1和KCNH2互作可能调节长qt综合征1型表型
Katja E Odening
Katja E Odening
Remo Poto,Gianni Marone,Stephen J Galli et al.
Remo Poto et al.
Mast cells are tissue-resident immune cells strategically located in different compartments of the normal human heart (the myocardium, pericardium, aortic valve, and close to nerves) as well as in atherosclerotic plaques. Cardiac mast cells...
ATP13A3 variants promote pulmonary arterial hypertension by disrupting polyamine transport [0.03%]
ATP13A3变异通过破坏多胺转运促进肺动脉高压
Bin Liu,Mujahid Azfar,Ekaterina Legchenko et al.
Bin Liu et al.
Aims: Potential loss-of-function variants of ATP13A3, the gene encoding a P5B-type transport ATPase of undefined function, were recently identified in patients with pulmonary arterial hypertension (PAH). ATP13A3 is implic...
Endothelial nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome regulation in atherosclerosis [0.03%]
动脉粥样硬化中内皮NOD样受体蛋白3炎性小体的调节作用研究
Shuai Guo,Litao Wang,Kaixiang Cao et al.
Shuai Guo et al.
Aims: The activation of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome in endothelial cells (ECs) contributes to vascular inflammation in atherosclerosis. Considering the high glyco...
Blood-based cardiometabolic phenotypes in atrial fibrillation and their associated risk: EAST-AFNET 4 biomolecule study [0.03%]
心房颤动的基于血液的心元表型及其相关风险：EAST-AFNET 4生物标志物研究
Larissa Fabritz,Winnie Chua,Victor R Cardoso et al.
Larissa Fabritz et al.
Aims: Atrial fibrillation (AF) and concomitant cardiometabolic disease processes interact and combine to lead to adverse events, such as stroke, heart failure, myocardial infarction, and cardiovascular death. Circulating ...
Observational Study
Cardiovascular research. 2024 Jul 2;120(8):855-868. DOI:10.1093/cvr/cvae067 2024
DNA double-stranded breaks, a hallmark of aging, defined at the nucleotide resolution, are increased and associated with transcription in the cardiac myocytes in LMNA-cardiomyopathy [0.03%]
核苷酸分辨率定义的DNA双链断裂(衰老的重要标志)在LMNA心肌病的心脏肌肉细胞中增加并与转录有关
Benjamin Cathcart,Sirisha M Cheedipudi,Leila Rouhi et al.
Benjamin Cathcart et al.
Aims: An intrinsic feature of gene transcription is the formation of DNA superhelices near the transcription bubble, which are resolved upon induction of transient double-stranded breaks (DSBs) by topoisomerases. Unrepair...