Proteomics couples electrical remodelling to inflammation in a murine model of heart failure with sinus node dysfunction [0.03%]
蛋白质组学将电重构与炎症偶联在窦房结功能不全型心力衰竭小鼠模型中的研究
Konstantin Kahnert,Luca Soattin,Robert W Mills et al.
Konstantin Kahnert et al.
Aims: In patients with heart failure (HF), concomitant sinus node dysfunction (SND) is an important predictor of mortality, yet its molecular underpinnings are poorly understood. Using proteomics, this study aimed to diss...
NOT lost in translation: translatome mapping as a novel approach to identify regulators of atherosclerosis [0.03%]
未译失的翻译：转录组定位映射作为识别动脉粥样硬化调节因子的新方法
Ljubica Matic,Melody Chemaly,Helle F Jørgensen
Ljubica Matic
Mechanisms of ischaemia-induced arrhythmias in hypertrophic cardiomyopathy: a large-scale computational study [0.03%]
肥厚型心肌病中由缺血引起的心律失常机制：一项大规模计算研究
James A Coleman,Ruben Doste,Zakariye Ashkir et al.
James A Coleman et al.
Aims: Lethal arrhythmias in hypertrophic cardiomyopathy (HCM) are widely attributed to myocardial ischaemia and fibrosis. How these factors modulate arrhythmic risk remains largely unknown, especially as invasive mapping ...
Aquaporins enriched in endothelial vacuole membrane regulate the diameters of microvasculature in hyperglycemia [0.03%]
富集于内皮细胞液泡膜上的水通道蛋白调节高血糖微血管直径
Changsheng Chen,Yinyin Qin,Yidan Xu et al.
Changsheng Chen et al.
Background: In patients with diabetic microvascular complications, decreased perfusion or vascular occlusion, caused by reduced vascular diameter, is a common characteristic that will lead to insufficient blood supply. Ye...
Inhibition of CDK7 mitigates doxorubicin cardiotoxicity and enhances anticancer efficacy [0.03%]
CDK7抑制剂减轻阿霉素心肌毒性并增强抗癌疗效
Jingrui Chen,Jing Wei,Peng Xia et al.
Jingrui Chen et al.
Aims: The anthracycline family of anticancer agents such as doxorubicin (DOX) can induce apoptotic death of cardiomyocytes and cause cardiotoxicity. We previously reported that DOX-induced apoptosis is accompanied by card...
NLRP3 inflammasome-mediated premature immunosenescence drives diabetic vascular aging dependent on the induction of perivascular adipose tissue dysfunction [0.03%]
NLRP3炎性小体介导的过早免疫衰老驱动糖尿病血管衰老，依赖于诱导血管周围脂肪组织功能障碍
Guang-Jie Tai,Yan-Jie Ma,Jun-Lin Feng et al.
Guang-Jie Tai et al.
Aims: The vascular aging process accelerated by type 2 diabetes mellitus (T2DM) is responsible for the elevated risk of associated cardiovascular diseases (CVDs). Metabolic disorder-induced immune senescence has been impl...
Jessa L Aldridge,Emily Davis Alexander,Allison A Franklin et al.
Jessa L Aldridge et al.
Ncf1 knockout in SMCs exacerbates angiotensin II-induced aortic aneurysm and dissection by activating the STING pathway [0.03%]
Ncf1敲除通过激活STING途径加剧血管平滑肌细胞中Ang II诱导的胸主动脉瘤和夹层形成
Hao Liu,Peiwen Yang,Shu Chen et al.
Hao Liu et al.
Aims: Aortic aneurysm and dissection (AAD) is caused by the progressive loss of aortic smooth muscle cells (SMCs) and is associated with a high mortality rate. Identifying the mechanisms underlying SMC apoptosis is crucia...
Isthmin-1 alleviates cardiac ischemia/reperfusion injury through cGMP-PKG signaling pathway [0.03%]
Isthmin-1通过cGMP-PKG信号通路缓解心脏缺血/再灌注损伤
Min Hu,Xin Zhang,Can Hu et al.
Min Hu et al.
Aims: Ischemia/reperfusion (I/R) injury is an important complication of reperfusion therapy for acute myocardial infarction, extremely compromising the cardiac benefits of revascularization, however, specific and efficien...
Aiste Liutkute,Benjamin L Prosser,Niels Voigt
Aiste Liutkute