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Inhibition of CDK7 mitigates doxorubicin cardiotoxicity and enhances anticancer efficacy

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Aims: The anthracycline family of anticancer agents such as doxorubicin (DOX) can induce apoptotic death of cardiomyocytes and cause cardiotoxicity. We previously reported that DOX-induced apoptosis is accompanied by cardiomyocyt... ...