CPT1B-Mediated Fatty Acid Oxidation Induces Pigmentation in Solar Lentigo [0.03%]
CPT1B介导的脂肪酸氧化诱导太阳色斑形成
Yueun Choi,Uijeong Nam,Jihan Kim et al.
Yueun Choi et al.
Cellular senescence is associated with altered lipid metabolism, including increased cellular lipid uptake, upregulated lipid biosynthesis, and deregulated lipid breakdown. Previous studies have reported that carnitine palmitoyltransferase ...
An Integrated Investigation of SOX10 in Feather Color in Domestic Rock Pigeon (Columba livia) [0.03%]
家岩鸽(SOX10在家禽羽毛颜色中的综合调查)
Eric T Domyan,Shannon Baker,Whitney Brownlee et al.
Eric T Domyan et al.
The transcription factor SOX10 plays an important role in promoting determination and differentiation of melanocytes, and mutations affecting SOX10 expression or function often result in dramatic pigment phenotypes. In domestic rock pigeon,...
Pavel Pospíšil,Vendula Paculová,Ankush Prasad et al.
Pavel Pospíšil et al.
Chemiexcitation, the formation of electronically excited states via oxidative chemical reactions, has emerged as a potentially important contributor to skin photobiology beyond direct damage caused by ultraviolet (UV) radiation. This study ...
Proceeding Report of the Sixth Vitiligo International Symposium-December 13-15, 2024, Cairo, Egypt [0.03%]
第六届白癜风国际研讨会报告（2024年12月13日至15日，埃及开罗）
Samia Esmat,Marwa Abdallah,Dalia Bassiony et al.
Samia Esmat et al.
This article highlights the most recent updates in vitiligo that were presented in the sixth Vitiligo International Symposium, which was held in Cairo, Egypt from 13 to 15 December 2024. During this conference, worldwide vitiligo experts sh...
The Incorporation of Melanosomes by Senescent Keratinocytes Causes the Accumulation of Melanin due to Decreased Energy Metabolism [0.03%]
衰老角质形成细胞通过能量代谢下降摄取黑色素体导致黑色素沉积
Hiroko Yamazaki,Hideya Ando
Hiroko Yamazaki
In solar lentigo, a typical age-related pigmentary disorder of the skin, abundant melanin is deposited in the basal layer of keratinocytes and not spontaneously eliminated. The reason for the prolonged melanin accumulation in keratinocytes ...
Fusion Gene Detection in Driver Mutation-Negative Melanomas Using RNA-Based Anchored Multiplex Polymerase Chain Reaction [0.03%]
基于RNA的锚定多重聚合酶链反应在驱动基因阴性黑色素瘤中检测融合基因
Tokimasa Hida,Masashi Idogawa,Sayuri Sato et al.
Tokimasa Hida et al.
Advanced melanoma is typically treated with immune checkpoint inhibitors (ICIs) and targeted therapies. However, their efficacy is limited in acral and mucosal melanomas, which are more prevalent in non-White populations and often exhibit l...
Noninvasive Assessment of Melasma Pathological Features: Side-By-Side Comparison of Two-Photon Microscopy and Reflectance Confocal Microscopy [0.03%]
用于评估黄褐斑病理特征的非侵入式手段：双光子显微镜与反射共聚焦显微镜的对比研究
Xiaoli Ning,Jungang Yang,Hongfei Ouyang et al.
Xiaoli Ning et al.
Melasma, a refractory hyperpigmentation disorder, requires noninvasive tools for accurate pathological assessment. This study compared two-photon microscopy (TPM) and reflectance confocal microscopy (RCM) for the in vivo characterization of...
Comparative Study
Pigment cell & melanoma research. 2025 Nov;38(6):e70057. DOI:10.1111/pcmr.70057 2025
Germline CDKN2A Variant Cascade Testing Across Four Generations Reveals Familial Melanoma-Breast Cancer Genotype-Phenotype Correlation [0.03%]
横跨四代的遗传性CDKN2A基因型渐变检测发现家族性黑色素瘤-乳腺癌基因型与表型的相关性
Jennifer Berkman,Ellie J Maas,E DeBortoli et al.
Jennifer Berkman et al.
This study reports co-segregation of a pathogenic CDKN2A variant with both melanoma and breast cancer in a four-generation pedigree. Eighteen individuals were test positive (n = 10), obligate (n = 5) or assumed carriers (n = 3) of the CDKN2...
Gennie L Parkman,Xiaonan Xu,Sheri L Holmen et al.
Gennie L Parkman et al.
Since its discovery more than a quarter century ago, PTEN has emerged as one of the most potent tumor suppressors and its loss of function is common to numerous cancer types including glioblastoma, prostate cancer, small cell lung cancer, a...
Pauliina E Repo,Eveliina Jakkula,Juho Hiltunen et al.
Pauliina E Repo et al.
Some patients with uveal melanoma (UM) show genetic cancer predisposition: ~2% harbor a pathogenic or likely pathogenic (P/LP) germline variant in BAP1 or, rarely, in 20 other cancer-associated genes. Up to 75% of patients with familial UM ...