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The Incorporation of Melanosomes by Senescent Keratinocytes Causes the Accumulation of Melanin due to Decreased Energy Metabolism

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In solar lentigo, a typical age-related pigmentary disorder of the skin, abundant melanin is deposited in the basal layer of keratinocytes and not spontaneously eliminated. The reason for the prolonged melanin accumulation in keratinocytes is not fully underst... ...