A novel zebrafish luminescent biosensor for kidney tubulopathy, metal toxicity, and drug screening [0.03%]
一种新颖的斑马鱼发光生物传感器用于肾小管病变、金属毒性和药物筛选
Han Lai,Monica Goldade,Svenja Aline Keller et al.
Han Lai et al.
An efficient endolysosomal pathway is crucial to mediate the reabsorption and processing of ultrafiltered solutes including low-molecular-weight (LMW) proteins by epithelial cells lining the proximal tubule (PT) of the kidney. The zebrafish...
Identification and credentialing of invasive lobular carcinoma patient-derived Xenograft models [0.03%]
侵袭性小叶癌患者来源异种移植模型的鉴定和认证
Jagmohan Hooda,Jennifer M Atkinson,Osama Shiraz Shah et al.
Jagmohan Hooda et al.
Invasive lobular cancer (ILC) is the most common special breast cancer subtype, accounting for 10-15% of all cases. The pathognomonic feature of ILC is loss of E-cadherin (CDH1), leading to discohesive single-file growth. Although ILCs show...
Bone marrow microenvironment in aplastic anemia: insights from Nestin/CXCL12 immunohistochemistry and RNA-sequencing [0.03%]
骨髓细胞因子微环境在再生障碍性贫血中的改变及意义：巢蛋白和CXC基序趋化因子12免疫组化的组织病理学与RNA测序的见解
A Beerlage,C P Zinner,J R Passweg et al.
A Beerlage et al.
Aplastic anemia (AA) is a rare bone marrow failure syndrome characterized by immune-mediated destruction of hematopoietic stem and progenitor cells (HSPCs). The contribution of the bone marrow microenvironment remains incompletely understoo...
An innovative in vitro model for studying the biology of cardiac fibroblasts originating from the epicardium [0.03%]
一种新颖的体外模型用于研究起源于心外膜的心脏纤维母细胞的生物学特性
Claudia Müller-Sánchez,María Gertrudis Muñiz-Banciella,Manuel Reina et al.
Claudia Müller-Sánchez et al.
Embryonic epicardium is a major source of cardiac fibroblasts (CFs), which play essential roles in heart development and response to heart injury. In this study, we developed a novel mouse model to identify distinct populations of epicardiu...
Katherine Brown,E Elizabeth Patton,Rachel Hackett
Katherine Brown
Roger S Smith,Marc L Mendillo
Roger S Smith
The heat shock response is a highly conserved cellular defense mechanism against proteotoxic stress, characterized by the induction of heat shock proteins (HSPs) that function as molecular chaperones to maintain protein homeostasis. Central...
Hans Clevers
Hans Clevers
Embryonic spinocerebellar ataxia type 37 AUUUC repeat RNA causes neurodevelopmental defects in zebrafish [0.03%]
胚胎期脊髓小脑共济失调37型AUUUC重复RNA导致斑马鱼神经发育缺陷
Ana F Castro,Ana S Figueiredo,Joana R Loureiro et al.
Ana F Castro et al.
Onset of many neurodegenerative and neuromuscular diseases usually starts in adulthood; however, recent advances point toward neurodevelopmental changes as drivers of late neurodegeneration. How early neuropathological features occur in the...
Maryam Clark,Timothy J Edwards,Dawn Savery et al.
Maryam Clark et al.
Chiari II brain malformation affects 90% of children with open spina bifida. Hindbrain herniation leads to hydrocephalus, together with higher brain anomalies including cerebral cortical defects implicated in learning disability, which affe...
Systematic structure-based analysis of RET variants in MEN2A, Hirschsprung's disease, and their paradoxical co-occurrence [0.03%]
MEN2A、先天性巨结肠症及其相互矛盾共发生的RET变异的系统结构基础分析
Anna Fassler Bakhman,Michal Cohen,Rachel Kolodny et al.
Anna Fassler Bakhman et al.
Mutations in the human receptor tyrosine kinase RET can cause loss-of-function and Hirschsprung's disease (HSCR), while activating RET mutations drive cancers including multiple endocrine neoplasia type 2 (MEN2). Paradoxically, some mutatio...