A genetic model of congenital intestinal atresia implicates Mypt1 in epithelial organisation [0.03%]
遗传模型揭示Mypt1基因与先天性肠梗阻关联性及其在上皮组织中的作用机制
Daisuke Kobayashi,Akihiro Urasaki,Tetsuaki Kimura et al.
Daisuke Kobayashi et al.
Congenital intestinal atresia (IA) is a birth defect characterised by the absence or closure of part of the intestine. Although genetic factors are implicated, mechanistic understanding has been hindered by the lack of suitable animal model...
A yeast synthetic biotic platform for delivery of therapeutic nanobodies to ameliorate gastrointestinal inflammation [0.03%]
一种酵母合成生物技术平台 用于输送治疗性纳米抗体以改善胃肠道炎症
Roger Palou,Almer M van der Sloot,Aline A Fiebig et al.
Roger Palou et al.
Protein-based pharmaceuticals, such as engineered antibodies, form a major drug class of steadily increasing market share. However, these biologic medicines are costly to manufacture, are subject to strict supply chain and storage constrain...
Evidence that xylazine disrupts skin homeostasis by acting on epithelial cells through the kappa opioid receptor [0.03%]
小鼠实验揭示 cas 合用春黄菊酚作用于外周 κ-阿片受体抑制痒觉神经元活动及抓挠行为
Tanner F Robertson,Adam Horn,Frances M Smith et al.
Tanner F Robertson et al.
The veterinary sedative and alpha-2 adrenergic receptor (α2AR) agonist xylazine, found in the illicit opioid supply, is associated with cutaneous wounds in humans. Here, we develop a larval zebrafish model of xylazine-induced tissue damage...
Development and characterization of a model of mucopolysaccharidosis type IVA for evaluating therapies targeting bone disease [0.03%]
I型黏多糖贮积症骨病治疗药物评估鼠模型的建立及鉴定
Margherita Berti,Selene Ceriotti,Ludovica Santi et al.
Margherita Berti et al.
Mucopolysaccharidosis type IVA (MPSIVA) is a lysosomal storage disease (LSD) caused by deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS), which causes the accumulation of keratan sulphate (KS) and chondroitin sulphate (CS). Pa...
Kirsty Hooper,Dina Mikimoto,Rachel Hackett et al.
Kirsty Hooper et al.
Transcriptomic and proteomic insights into progressive myoclonus epilepsy, EPM1 [0.03%]
渐进性肌阵挛癫痫(EPM1)的转录组和蛋白质组的新见解
Alina Malyutina,Carina Lund,Saara Tegelberg et al.
Alina Malyutina et al.
Progressive myoclonus epilepsy EPM1 is a rare neurodegenerative disease caused by partial loss of function of cystatin B (CSTB), a cysteine protease inhibitor with known neuroprotective roles. The disease mechanisms remain largely unsolved,...
Inflammatory responses following CRISPR modification of the nuclear localisation sequence in endogenous interleukin-1alpha [0.03%]
内源性白细胞介素1α核定位序列经CRISPR编辑后的炎症反应
Christopher Hoyle,Rodrigo Díaz Pino,Si Min Lai et al.
Christopher Hoyle et al.
Interleukin (IL)-1α is a pro-inflammatory member of the IL-1 cytokine superfamily and is important for inflammatory responses to infection and injury. Unlike pro-IL-1β, pro-IL-1α is mainly localised to the nucleus upon expression. This i...
Human induced pluripotent stem cell-derived inner ear organoids reveal hair cell damage and plasticity after cisplatin and gentamicin exposure [0.03%]
人诱导多能干细胞来源内耳类器官揭示顺铂和庆大霉素暴露后的毛细胞损伤及可塑性
Amy W A Lucassen,Winnie M C van den Boogaard,Esther Fousert et al.
Amy W A Lucassen et al.
Ototoxicity is a leading cause of sensory deficits, including hearing loss and balance disorders. Predicting ototoxicity is challenging owing to translatability issues of animal models and limited access to human inner ear tissue. Known oto...
Cell-type-specific alternative splicing in the brain and kidney of a Setbp1S858R Schinzel-Giedion syndrome mouse [0.03%]
Setbp1S858R综合症小鼠脑和肾中细胞类型特异性的可变剪接
Tabea M Soelter,Emma F Jones,Timothy C Howton et al.
Tabea M Soelter et al.
Schinzel-Giedion syndrome (SGS) is an ultra-rare Mendelian disorder caused by gain-of-function variants in the SETBP1 gene. Although previous studies determined multiple roles for SETBP1 and its associated pathways in disease manifestation,...
Lori A Forster,David H Gutmann
Lori A Forster
The application of advanced multi-omic methodologies to studying brain tumors has culminated in the appreciation that these cancers function as ecosystems that depend on the interactions of a diverse collection of cell types and signals. Th...