Evaluating skeletal muscle dysfunction and recovery in a zymosan model of critical illness in mice [0.03%]
Amy J Bongetti,Annabel Chee,John H V Nguyen et al.
Amy J Bongetti et al.
Muscle wasting and weakness are common complications associated with critical illness and admission to the Intensive Care Unit (ICU), that contribute to increased mortality and health deficits post-discharge. The mechanisms underlying ICU-a...
Loss of Cathepsin Z enhances pro-inflammatory macrophage responses and promotes tissue regeneration [0.03%]
Thais Sibioni Berti Bastos,Catherine A Loynes,Zoë C Speirs et al.
Thais Sibioni Berti Bastos et al.
The plasticity of macrophages is well documented, with fundamental roles in modulating inflammation and promoting tissue repair, notably aiming to maintain homeostasis in multicellular organisms. However, the precise factors that regulate t...
Dolutegravir developmental toxicity is mitigated by magnesium and folate in zebrafish embryos [0.03%]
Robert M Cabrera,Ahmed Mohamed,Ryoko Minowa et al.
Robert M Cabrera et al.
Integrase strand transfer inhibitors have transformed HIV therapy, yet the widely prescribed drug dolutegravir (DTG) has been linked to developmental toxicity and its teratogenic mechanism remains unclear. Here we use zebrafish to dissect D...
Distinct cellular effects of myotonic dystrophy type 2 RAN tetrapeptides in Drosophila melanogaster [0.03%]
果蝇中的肌强直性营养不良2型RAN四肽在细胞中产生不同的效应
Marta Marzullo,Assia De Simone,Marta Terribili et al.
Marta Marzullo et al.
Myotonic dystrophy type 2 (DM2) is an autosomal dominant, multisystemic disorder caused by the expansion of CCTG repeats in the first intron of the CNBP gene. Repeat-associated non-AUG (RAN) translation of the expanded CCTG RNA generates tw...
Transgenic mouse models for investigating human DUX4 expression during development and its roles in FSHD pathophysiology [0.03%]
用于研究人类DUX4在发育过程中的表达及其在FSHD病理生理学中作用的转基因小鼠模型
Yosuke Hiramuki,Charis L Himeda,Peter L Jones et al.
Yosuke Hiramuki et al.
Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant myopathy caused by aberrant expression of the DUX4 retrogene, and it affects skeletal muscles primarily in the face, shoulder, and limbs. In healthy individuals, DUX4 is...
A novel zebrafish luminescent biosensor for kidney tubulopathy, metal toxicity, and drug screening [0.03%]
一种新颖的斑马鱼发光生物传感器用于肾小管病变、金属毒性和药物筛选
Han Lai,Monica Goldade,Svenja Aline Keller et al.
Han Lai et al.
An efficient endolysosomal pathway is crucial to mediate the reabsorption and processing of ultrafiltered solutes including low-molecular-weight (LMW) proteins by epithelial cells lining the proximal tubule (PT) of the kidney. The zebrafish...
Identification and credentialing of invasive lobular carcinoma patient-derived Xenograft models [0.03%]
侵袭性小叶癌患者来源异种移植模型的鉴定和认证
Jagmohan Hooda,Jennifer M Atkinson,Osama Shiraz Shah et al.
Jagmohan Hooda et al.
Invasive lobular cancer (ILC) is the most common special breast cancer subtype, accounting for 10-15% of all cases. The pathognomonic feature of ILC is loss of E-cadherin (CDH1), leading to discohesive single-file growth. Although ILCs show...
Bone marrow microenvironment in aplastic anemia: insights from Nestin/CXCL12 immunohistochemistry and RNA-sequencing [0.03%]
骨髓细胞因子微环境在再生障碍性贫血中的改变及意义：巢蛋白和CXC基序趋化因子12免疫组化的组织病理学与RNA测序的见解
A Beerlage,C P Zinner,J R Passweg et al.
A Beerlage et al.
Aplastic anemia (AA) is a rare bone marrow failure syndrome characterized by immune-mediated destruction of hematopoietic stem and progenitor cells (HSPCs). The contribution of the bone marrow microenvironment remains incompletely understoo...
An innovative in vitro model for studying the biology of cardiac fibroblasts originating from the epicardium [0.03%]
一种新颖的体外模型用于研究起源于心外膜的心脏纤维母细胞的生物学特性
Claudia Müller-Sánchez,María Gertrudis Muñiz-Banciella,Manuel Reina et al.
Claudia Müller-Sánchez et al.
Embryonic epicardium is a major source of cardiac fibroblasts (CFs), which play essential roles in heart development and response to heart injury. In this study, we developed a novel mouse model to identify distinct populations of epicardiu...
Katherine Brown,E Elizabeth Patton,Rachel Hackett
Katherine Brown