A temporal dialogue between the circadian clock and chronic inflammatory diseases [0.03%]
昼夜钟与慢性炎症疾病之间的时空对话机制研究进展
Siyu Chen,David Ray
Siyu Chen
The circadian clock is an intrinsic molecular system that synchronises biological processes with daily environmental cycles. Under physiological conditions, cell-intrinsic clocks and systemic cues together regulate the circadian rhythmicity...
Debora Bogani,Kirsty Hooper,Owen Sansom
Debora Bogani
Alex's Lemonade Stand Foundation squeezes in hope for childhood cancer: an interview with Liz and Jay Scott [0.03%]
柠檬汁里的希望：与利亚和杰·斯科特访谈alex的柠檬汁摊基金会创始人
Liz Scott,Jay Scott,Alex&#x;s Lemonade Stand Foundation
Liz Scott
C. elegans models of alternating hemiplegia of childhood have dominant neuromuscular junction defects [0.03%]
秀丽隐杆线虫儿童交替性半身瘫痪模型具有显性的神经肌肉突触缺陷
Diana A Wall,Adam M Friedberg,Jeremy Lins et al.
Diana A Wall et al.
Dominant missense mutations in ATP1A3, encoding a Na+, K+ ATPase α-3 subunit, can cause Alternating Hemiplegia of Childhood (AHC), but how these mutations lead to AHC remains unclear. Here, we establish the first C. elegans AHC models by i...
Myeloperoxidase impairs mucociliary transport on human airway epithelium [0.03%]
髓过氧化物酶损害人呼吸道上皮的粘液纤毛传输功能
Allison Boboltz,Vaidehi Rathi,Sahana Kumar et al.
Allison Boboltz et al.
Dampening neutrophil-driven inflammation in the airways remains a challenge in treating cystic fibrosis (CF) lung disease. Myeloperoxidase (MPO) is a neutrophilic enzyme that produces reactive oxygen species and is highly concentrated in CF...
Evaluating skeletal muscle dysfunction and recovery in a zymosan model of critical illness in mice [0.03%]
评估zymosan诱导的小鼠重症模型中骨骼肌功能障碍和恢复状况
Amy J Bongetti,Annabel Chee,John H V Nguyen et al.
Amy J Bongetti et al.
Muscle wasting and weakness are common complications associated with critical illness and admission to the Intensive Care Unit (ICU), that contribute to increased mortality and health deficits post-discharge. The mechanisms underlying ICU-a...
Loss of Cathepsin Z enhances pro-inflammatory macrophage responses and promotes tissue regeneration [0.03%]
Cathepsin Z丧失增强了促炎巨噬细胞的反应并促进组织再生
Thais Sibioni Berti Bastos,Catherine A Loynes,Zoë C Speirs et al.
Thais Sibioni Berti Bastos et al.
The plasticity of macrophages is well documented, with fundamental roles in modulating inflammation and promoting tissue repair, notably aiming to maintain homeostasis in multicellular organisms. However, the precise factors that regulate t...
Dolutegravir developmental toxicity is mitigated by magnesium and folate in zebrafish embryos [0.03%]
镁和叶酸可缓解多拉替尼在斑马鱼胚胎中的发育毒性
Robert M Cabrera,Ahmed Mohamed,Ryoko Minowa et al.
Robert M Cabrera et al.
Integrase strand transfer inhibitors have transformed HIV therapy, yet the widely prescribed drug dolutegravir (DTG) has been linked to developmental toxicity and its teratogenic mechanism remains unclear. Here we use zebrafish to dissect D...
Distinct cellular effects of myotonic dystrophy type 2 RAN tetrapeptides in Drosophila melanogaster [0.03%]
果蝇中的肌强直性营养不良2型RAN四肽在细胞中产生不同的效应
Marta Marzullo,Assia De Simone,Marta Terribili et al.
Marta Marzullo et al.
Myotonic dystrophy type 2 (DM2) is an autosomal dominant, multisystemic disorder caused by the expansion of CCTG repeats in the first intron of the CNBP gene. Repeat-associated non-AUG (RAN) translation of the expanded CCTG RNA generates tw...
Transgenic mouse models for investigating human DUX4 expression during development and its roles in FSHD pathophysiology [0.03%]
用于研究人类DUX4在发育过程中的表达及其在FSHD病理生理学中作用的转基因小鼠模型
Yosuke Hiramuki,Charis L Himeda,Peter L Jones et al.
Yosuke Hiramuki et al.
Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant myopathy caused by aberrant expression of the DUX4 retrogene, and it affects skeletal muscles primarily in the face, shoulder, and limbs. In healthy individuals, DUX4 is...