Distinct cellular effects of myotonic dystrophy type 2 RAN tetrapeptides in Drosophila melanogaster
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Myotonic dystrophy type 2 (DM2) is an autosomal dominant, multisystemic disorder caused by the expansion of CCTG repeats in the first intron of the CNBP gene. Repeat-associated non-AUG (RAN) translation of the expanded CCTG RNA generates two tetrapeptide repea... ...
