Repurposing Purine Analog Antivirals to Modulate Serum Uric Acid: Evidence From Real-World Data [0.03%]
从真实世界数据看嘌呤类似物抗病毒药物适应症重新定位以调节血尿酸水平：来自真实世界数据的证据
Joseph Magagnoli,Tammy H Cummings,Michael D Wyatt et al.
Joseph Magagnoli et al.
Xanthine oxidase (XO) inhibitors remain the standard pharmacologic therapy for hyperuricemia. However, additional enzymatic components of the purine degradation pathway may contribute to uric acid synthesis. Guanine deaminase (GD) catalyzes...
Physicians' Perceptions of Prescribing in Pregnancy and Package Inserts: A Survey of General and Hub Hospitals in Japan [0.03%]
日本医师对孕期处方的感知及药物说明书调查——来自普通医院和中心医院的报告
Mikako Goto,Naho Yakuwa,Atsuko Murashima
Mikako Goto
This study investigated how Japanese physicians make decisions about prescribing medications during pregnancy, based on safety information provided in drug package inserts. An online questionnaire survey targeted physicians working at pregn...
A Phase 1 Microtracer Study Evaluating the Mass Balance, Excretion, and Pharmacokinetics of Osivelotor in Healthy Participants [0.03%]
一项在健康受试者中评估osivelotor质量平衡、排泄和药代动力学的1期微示踪剂研究
Eric I Zimmerman,Ernesto Callegari,Raman Sharma et al.
Eric I Zimmerman et al.
Osivelotor (GBT021601) is an orally bioavailable, small molecule hemoglobin polymerization inhibitor in clinical development for the treatment of sickle cell disease (SCD). In this Phase 1 study, the disposition of osivelotor was assessed u...
Clinical Trial
Clinical and translational science. 2026 Jun;19(6):e70601. DOI:10.1111/cts.70601 2026
Effects of Nacubactam and Its Metabolites on QTc Interval: A Pooled Analysis of Two Randomized Phase 1 Studies [0.03%]
纳库巴塔姆及其代谢产物对QTc间期影响的汇总分析：两项随机I期临床研究的结果
Jun Morita,Sue McKendrick,Yuji Kumagai
Jun Morita
Nacubactam is a β-lactamase inhibitor. Early-phase studies with 1000/2000/4000/8000 mg nacubactam monotherapy were not powered to assess proarrhythmic risk. Therefore, this analysis pooled electrocardiogram data from two placebo-controlled...
Clinical Trial
Clinical and translational science. 2026 Jun;19(6):e70621. DOI:10.1111/cts.70621 2026
Safety and Efficacy of HexaBody-DR5/DR5 in Malignant Solid Tumors: Phase 1/2a Results and Translational Insights Into Observed Hepatotoxicity [0.03%]
HexaBody-DR5/DR5治疗恶性实体瘤的Ib/IIa期临床试验结果及其所致肝毒性的转化医学研究见解
Marije B Overdijk,Kristin Strumane,Ruth Plummer et al.
Marije B Overdijk et al.
HexaBody-DR5/DR5 (GEN1029) is a death receptor 5 (DR5) agonist composed of two humanized immunoglobulin G1 (IgG1) antibodies, Hx-DR5-01 and Hx-DR5-05, that bind non-overlapping DR5 epitopes with nanomolar affinity. HexaBody-DR5/DR5 is desig...
Clinical Trial
Clinical and translational science. 2026 Jun;19(6):e70546. DOI:10.1111/cts.70546 2026
Highlighting Rigor, Reproducibility, and Transparency of Research in an Academic CV [0.03%]
在学术简历中强调研究的严谨性、可重复性和透明度
Mario Malički,Zach Chandler,Steven N Goodman
Mario Malički
In academia, the curriculum vitae (CV) is the central document used for hiring, promotion, or tenure applications. The content and format of these CVs and accompanying documents varies among institutions and is a direct reflection of the in...
Simulated Y-Site Compatibility of Calcium Gluconate and Benzylpenicillin With Maintenance Fluid Used in Neonatal Intensive Care Unit [0.03%]
用于新生儿重症监护病房的葡萄糖酸钙和青霉素苯甲醇模拟Y型接口相容性研究
Ayman Allahham,Robert Pulbrook,Billy Lo et al.
Ayman Allahham et al.
Maintenance fluids for neonates, which are commonly composed of glucose 10%, sodium chloride (NaCl) 0.225% w/v with potassium chloride (KCl) 20 mmol/L (GSP), are administered as a continuous infusion, and prescribed medications are required...
CYP2C19 Polymorphism and Platelet Aggregation-Associated Risks in Atrial Fibrillation Patients Undergoing PCI [0.03%]
房颤患者经皮冠状动脉介入术围手术期血小板聚集及CYP2C19基因多态性相关性的研究
Diona Gjermeni,Sofia Szabó,Viktoria Anfang et al.
Diona Gjermeni et al.
CYP2C19 genetic polymorphisms impact the antiplatelet effect of clopidogrel and associate with ischemic and bleeding risk in patients undergoing percutaneous coronary intervention (PCI). This study aimed to evaluate the association of CYP2C...
Multicenter Study
Clinical and translational science. 2026 Jun;19(6):e70598. DOI:10.1111/cts.70598 2026
From Precision to Personalized: Catalyzing AI-Enabled Innovation in Drug Development [0.03%]
从精准到个性化：催化药物开发领域的AI赋能创新
Adarsh Subbaswamy,Allison Dunn,Brooke Langevin et al.
Adarsh Subbaswamy et al.
In 2015, President Obama announced the Precision Medicine Initiative in his nationally televised State of the Union address. The vision was bold: to enable a new era of medicine through research, technology, and policies that empower patien...
Prevotella bivia Influences Antiretroviral Pharmacokinetics and Viral Replication in an Ex Vivo Vaginal Tissue Model [0.03%]
Prevotella bivia影响抗逆转录病毒药物动态学和病毒感染的体外模型阴道组织模型中的病毒复制
Alyssa M Lantz,Lindsey B Collins,Elizabeth B Hirsch et al.
Alyssa M Lantz et al.
The vaginal microbiome plays a complex role in tenofovir's mucosal pharmacology. While the relative contribution of systemic versus local concentrations to PrEP PK/PD is an ongoing debate, the development of effective HIV prevention require...