Benzbromarone as a Novel Candidate for Preventing Alzheimer's Disease: Evidence From Real-World Data Screening and in Vitro Validation [0.03%]
苯溴隆作为防治阿尔茨海默病的新型候选药物：来自真实世界数据分析和体外验证的证据
Sho Sakagami,Yuya Yoshida,Shota Uemura et al.
Sho Sakagami et al.
Drug development for Alzheimer's disease (AD) remains challenging, with only a 0.4% success rate from Phase I trials to regulatory approval. Drug repositioning leverages existing approved drugs to identify promising drug alternatives, parti...
Predictive Factors for Relapse in Still's Disease: A Retrospective Cohort Study of Clinical and Laboratory Biomarkers [0.03%]
Still病复发的预测因素：临床和实验室生物标志物的回顾性队列研究
İbrahim Yahya Çakır,Abdulsamet Erden,Yeter Mahmutoğlu et al.
İbrahim Yahya Çakır et al.
This retrospective cohort study aimed to identify clinical and laboratory predictors of relapse in patients with Still's disease. A total of 94 patients diagnosed by Yamaguchi or Fautrel criteria across two rheumatology centers between 2012...
Multicenter Study
Clinical and translational science. 2026 Jun;19(6):e70647. DOI:10.1111/cts.70647 2026
European Network on Optimizing Treatment With Therapeutic Antibodies in Chronic Inflammatory Diseases: Overview, Progress and Perspectives [0.03%]
用于慢性炎症性疾病疗效优化的治疗性抗体欧洲网络：概览、进展和展望
Konstantin Tachkov,Merita Rumano,James Bluett et al.
Konstantin Tachkov et al.
Treatment of chronic inflammatory diseases has been revolutionized with the introduction of targeted therapies using therapeutic antibodies. However, a large proportion of patients do not respond to treatment, or they lose response over tim...
When Science Outpaces Infrastructure: People, Process, and Technology Challenges for Precision Dosing in Children [0.03%]
当科学超越基础设施时：儿童精准给药的人为、流程和技术挑战
Tamorah Lewis,Karim Jessa,Vijay Ivaturi et al.
Tamorah Lewis et al.
The implementation of novel precision medicine tools in pediatric medicine requires buy-in from multiple interest groups and a shift from traditional medical paradigms. In an effort to implement a precision drug-dosing project for an anti-c...
From Pharmacodynamic Biomarker to Evaluating Treatment Response: Biomarkers in Primary Mitochondrial Diseases [0.03%]
从药理动力学生物标志物到评估治疗反应：原发性线粒体疾病中的生物标志物
Sydney Stern,Karryn Crisamore,John Patton et al.
Sydney Stern et al.
Primary mitochondrial diseases (PMDs) result from genetic variants in nuclear DNA and mitochondrial DNA which commonly lead to aberrant oxidative phosphorylation. The clinical complexity, often attributed to the underlying genetics, include...
Challenges in Implementing Revocation of Oncology Drugs Under Conditional Early Approval in Japan: Regulatory Insights From Comparisons With FDA/EMA [0.03%]
日本有条件提前批准的肿瘤药物撤市实施中的挑战——与FDA/EMA比较后的监管思考
Takahiro Handa,Arata Tanaka,Mayumi Shikano et al.
Takahiro Handa et al.
Expedited pathways in the United States (U.S.), European Union (EU), and Japan (JP) enable earlier access to innovative therapies for rare and serious diseases. In 2025, Japan explicitly introduced revocation provisions to its Conditional E...
Comparative Study
Clinical and translational science. 2026 Jun;19(6):e70642. DOI:10.1111/cts.70642 2026
Thorough QT/QTc Clinical Study to Evaluate the Effect of Remdesivir on Cardiac Repolarization in Healthy Participants [0.03%]
一项在健康受试者中评价瑞德西韦对心电图QT/QTc影响的临床研究
Chi-Chi Peng,Ran Duan,Mazin Abdelghany et al.
Chi-Chi Peng et al.
QT interval prolongation associated with drug administration is an important consideration in drug development. Patients with COVID-19 are at increased risk for cardiac complications, and QT interval prolongation correlates with higher mort...
Clinical Trial
Clinical and translational science. 2026 Jun;19(6):e70645. DOI:10.1111/cts.70645 2026
Transcriptomic Profiling of Cutaneous Melanoma Metastases Treated With Microwave Ablation-Pilot Study [0.03%]
微波消融治疗黑色素瘤转移病灶的转录组谱分析-一项初步研究
Purevsuren Losol,Daniel O&#x;Driscoll,Andres Vallejo Pulido et al.
Purevsuren Losol et al.
Microwave ablation induces heating of tissue. High energy results in thermal cell death, but low energy treatment without tissue necrosis has been shown to induce cutaneous immunity in an HPV wart model. It is approved as an effective cance...
A Generative AI Framework for Pharmacokinetic Clinical Study Report Authoring [0.03%]
一种用于药代动力学临床研究报告撰写的生成式AI框架
John Samuelsson,Samuel Blakeman,Ezra Alexander et al.
John Samuelsson et al.
Clinical Study Reports (CSRs) constitute the final consolidation of findings from clinical studies and routinely include Pharmacokinetic (PK) results. To assist with PK results authoring, we developed a generative Artificial Intelligence (A...
Utilization of Healthy Volunteers in Oncology Drug Development in Japan: A 10-Year Analysis of Approved Anticancer Agents (2014-2024) [0.03%]
日本肺癌药物开发中健康受试者利用情况（2014-2024）十年分析
Kana Morihisa,Hiroyuki Yoshitsugu,Hirokazu Wakuda et al.
Kana Morihisa et al.
Anticancer agents with favorable safety profiles, such as immunomodulators and molecular-targeted agents, are increasingly used in recent cancer therapy, and clinical trials for these agents increasingly incorporate healthy volunteers as we...