Differential PKA activation and AKAP association determines cell fate in cancer cells [0.03%]
PKA的不同激活方式及AKAP相互作用决定癌细胞的命运
Erik D Hedrick,Ekta Agarwal,Premila D Leiphrakpam et al.
Erik D Hedrick et al.
Background: The dependence of malignant properties of colorectal cancer (CRC) cells on IGF1R signaling has been demonstrated and several IGF1R antagonists are currently in clinical trials. Recently, we identified a novel ...
Direct RNA sequencing mediated identification of mRNA localized in protrusions of human MDA-MB-231 metastatic breast cancer cells [0.03%]
直接RNA测序鉴定人MDA-MB-231转移性乳腺癌细胞突起中定位的mRNA
Kristine Raaby Jakobsen,Emilie Sørensen,Karin Kathrine Brøndum et al.
Kristine Raaby Jakobsen et al.
Background: Protrusions of cancer cells conferrers a vital function for cell migration and metastasis. Protein and RNA localization mechanisms have been extensively examined and shown to play pivotal roles for the functio...
EGF regulates tyrosine phosphorylation and membrane-translocation of the scaffold protein Tks5 [0.03%]
表皮生长因子通过调节衔接蛋白Tks5的酪氨酸磷酸化和膜易位发挥功能
Anna Fekete,Gábor Bőgel,Szabolcs Pesti et al.
Anna Fekete et al.
Background: Tks5/FISH is a scaffold protein comprising of five SH3 domains and one PX domain. Tks5 is a substrate of the tyrosine kinase Src and is required for the organization of podosomes/invadopodia implicated in inva...
Ping Xie
Ping Xie
The tumor necrosis factor receptor (TNF-R)-associated factor (TRAF) family of intracellular proteins were originally identified as signaling adaptors that bind directly to the cytoplasmic regions of receptors of the TNF-R superfamily. The p...
Ovarian cancer G protein coupled receptor 1 suppresses cell migration of MCF7 breast cancer cells via a Gα12/13-Rho-Rac1 pathway [0.03%]
卵巢癌G蛋白偶联受体1通过Gα12/13-Rho-Rac1通路抑制MCF7乳腺癌细胞迁移
Jing Li,Bin Guo,Jing Wang et al.
Jing Li et al.
Background: Ovarian cancer G protein coupled receptor 1 (OGR1) mediates inhibitory effects on cell migration in human prostate and ovarian cancer cells. However, the mechanisms and signaling pathways that mediate these in...
NFAT5 in cellular adaptation to hypertonic stress - regulations and functional significance [0.03%]
细胞适应高渗性压力中的NFAT5调控及其功能意义
Chris Yk Cheung,Ben Cb Ko
Chris Yk Cheung
The Nuclear Factor of Activated T Cells-5 (NFAT5), also known as OREBP or TonEBP, is a member of the nuclear factors of the activated T cells family of transcription factors. It is also the only known tonicity-regulated transcription factor...
Aggressive neuroblastomas have high p110alpha but low p110delta and p55alpha/p50alpha protein levels compared to low stage neuroblastomas [0.03%]
与低阶段神经母细胞瘤相比，侵袭性神经母细胞瘤的p110alphahigh但p110 deltand p55 alphap50 alpha蛋白水平低
Susanne Fransson,Per Kogner,Tommy Martinsson et al.
Susanne Fransson et al.
Background: The phosphoinositide 3-kinase (PI3K)/Akt pathway is involved in neuroblastoma development where Akt/PKB activation is associated with poor prognosis. PI3K activity subsequently activates Akt/PKB, and as mutati...
Determinants at the N- and C-termini of Gα12 required for activation of Rho-mediated signaling [0.03%]
Gα12蛋白N端和C端激活Rho介导信号的必要决定位点
Benjamin J Ritchie,William C Smolski,Ellyn R Montgomery et al.
Benjamin J Ritchie et al.
Background: Heterotrimeric guanine nucleotide binding proteins of the G12/13 subfamily, which includes the α-subunits Gα12 and Gα13, stimulate the monomeric G protein RhoA through interaction with a distinct subset of ...
Caspase-3 mediated release of SAC domain containing fragment from Par-4 is necessary for the sphingosine-induced apoptosis in Jurkat cells [0.03%]
半胱天冬酶介导的SAC结构域蛋白片段的Par-4释放是硫辛酸诱导的Jurkat细胞凋亡所必需的
Faisal Thayyullathil,Siraj Pallichankandy,Anees Rahman et al.
Faisal Thayyullathil et al.
Background: Prostate apoptosis response-4 (Par-4) is a tumor-suppressor protein that selectively activates and induces apoptosis in cancer cells, but not in normal cells. The cancer specific pro-apoptotic function of Par-...
Consequences of nongenomic actions of estradiol on pathogenic genital tract response [0.03%]
雌二醇非基因组作用对病理性生殖道反应的后果
Paula Solar,Luis Velasquez
Paula Solar
Estradiol is a steroid hormone that regulates the structure and function of the female reproductive system. In addition to its genomic effects, which are mediated by activated nuclear receptors, estradiol elicits a variety of rapid signalin...