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Determinants at the N- and C-termini of Gα12 required for activation of Rho-mediated signaling

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Background: Heterotrimeric guanine nucleotide binding proteins of the G12/13 subfamily, which includes the α-subunits Gα12 and Gα13, stimulate the monomeric G protein RhoA through interaction with a distinct subset of Rho-spec... ...