Basal Signalling Through Death Receptor 5 and Caspase 3 Activates p38 Kinase to Regulate Serum Response Factor (SRF)-Mediated MyoD Transcription [0.03%]
通过死亡受体5和半胱氨酸天冬氨酸酶3激活的基底信号调节p38激酶介导的血清反应因子（SRF）转录活化_MYOD1
Jason A Ross,Brianna Barrett,Victoria Bensimon et al.
Jason A Ross et al.
We have previously reported that stable expression of a dominant negative Death Receptor 5 (dnDR5) in skeletal myoblasts results in decreased basal caspase activity and decreased mRNA and protein expression of the muscle regulatory transcri...
Lihua Tang,Kepeng Wang
Lihua Tang
Chronic inflammation is linked to the development and progression of multiple cancers, including those of the lung, stomach, liver, colon, breast and skin. Inflammation not only drives the oncogenic transformation of epithelial cells under ...
Gayane Machkalyan,Terence E Hèbert,Gregory J Miller
Gayane Machkalyan
Inositol hexakisphosphate kinase 2 (IP6K2) potentiates pro-apoptotic signalling and increases the sensitivity of mammalian cells to cytotoxic agents. Diphosphoinositol pentakisphosphate kinase (PPIP5K) generates inositol pyrophosphates (Ins...
MAGI Proteins Regulate the Trafficking and Signaling of Corticotropin-Releasing Factor Receptor 1 via a Compensatory Mechanism [0.03%]
MAGI蛋白通过补偿机制调节皮质醇释放因子受体1的转运和信号转导
Maha M Hammad,Henry A Dunn,Stephen S G Ferguson
Maha M Hammad
Corticotropin-releasing factor (CRF) receptor1 (CRFR1) is associated with psychiatric illness and is a proposed target for the treatment of anxiety and depression. Similar to many G protein-coupled receptors (GPCRs), CRFR1 harbors a PDZ (PS...
Joseph W Martin,Kyle S Cavagnini,Douglas N Brawley et al.
Joseph W Martin et al.
AKAP-Lbc is a Rho-activating guanine nucleotide exchange factor (RhoGEF) important in heart development and pro-fibrotic signaling in cardiomyocytes. Heterotrimeric G proteins of the G12/13 subfamily, comprising Gα12 and Gα13, are well ch...
Dylan Allen,Jin Seo
Dylan Allen
Cellular signaling pathways are often interconnected. They accurately and efficiently regulate essential cell functions such as protein synthesis, cell growth, and survival. The target of rapamycin (TOR) signaling pathway and the endoplasmi...
Transcriptional and Post-Translational Targeting of Myocyte Stress Protein 1 (MS1) by the JNK Pathway in Cardiac Myocytes [0.03%]
JNK信号转导途径在心肌细胞中作用于myocyte应激蛋白1(MS1)的转录和翻译后水平
Joanna M Hay,Eva S Jordan,Gareth J Browne et al.
Joanna M Hay et al.
Myocyte Stress Protein 1 (MS1) is a muscle-specific, stress-responsive, regulator of gene expression. It was originally identified in embryonic mouse heart which showed increased expression in a rat model of left ventricular hypertrophy. To...
Samrein B M Ahmed,Sally A Prigent
Samrein B M Ahmed
The Shc family of adaptor proteins is a group of proteins that lacks intrinsic enzymatic activity. Instead, Shc proteins possess various domains that allow them to recruit different signalling molecules. Shc proteins help to transduce an ex...
Anti-proliferative Effect of C3 Exoenzyme in Fibroblasts is Mediated by c-Jun Phosphorylation [0.03%]
C3肉毒类毒素的抗增殖效应通过c-Jun磷酸化介导
Leonie von Elsner,Sandra Hagemann,Ingo Just et al.
Leonie von Elsner et al.
The ADP-ribosyltransferase C3 exoenzyme from C. botulinum selectively inactivates Rho and is therefore often used as an inhibitor for investigations on Rho signaling. Previous studies of our group revealed that C3 inhibited cell proliferati...
Frizzled-4 C-terminus Distal to KTXXXW Motif is Essential for Normal Dishevelled Recruitment and Norrin-stimulated Activation of Lef/Tcf-dependent Transcriptional Activation [0.03%]
Fzrdd4C端的KTXXXW基序下游对于正常招募Dishevelled和Norrin激活的Lef/tcf依赖性转录活化是必不可少的
Alexander C Bertalovitz,Milly S Pau,Shujuan Gao et al.
Alexander C Bertalovitz et al.
The carboxy (C)-termini of G protein coupled receptors (GPCR) dictate essential functions. The KTXXXW motif C-terminus of Frizzleds (FZD) has been implicated in recruitment of Dishevelled (DVL). Through study of FZD4 and its associated liga...