Agonist mediated internalization of M2 mAChR is beta-arrestin-dependent [0.03%]
M2胆碱受体的内吞作用依赖于βarrestin蛋白质家族成员的作用
Kymry T Jones,Maria Echeverry,Valerie A Mosser et al.
Kymry T Jones et al.
Background: Muscarinic acetylcholine receptors (mAChRs) undergo agonist-promoted internalization, but evidence suggesting that the mechanism of internalization is beta-arrestin dependent has been contradictory and unclear...
Rac inhibits thrombin-induced Rho activation: evidence of a Pak-dependent GTPase crosstalk [0.03%]
Rac抑制血栓素诱导的Rho活化：一种Pak依赖型GTP酶串扰现象的证据
Hans Rosenfeldt,Maria Domenica Castellone,Paul A Randazzo et al.
Hans Rosenfeldt et al.
The strict spatio-temporal control of Rho GTPases is critical for many cellular functions, including cell motility, contractility, and growth. In this regard, the prototypical Rho family GTPases, Rho, Rac, and Cdc42 regulate the activity of...
Wei Guo,Lalitha Nagarajan
Wei Guo
Seven members of the Mix family of paired-type homeoproteins regulate mesoderm/endoderm differentiation in amphibians. In mammals, the MIXL1 (Mix. 1 homeobox [Xenopus laevis]-like gene 1) gene is the sole representative of this family. Unli...
Estradiol effects on the dopamine transporter - protein levels, subcellular location, and function [0.03%]
雌二醇对多巴胺转运蛋白的影响：蛋白质水平、亚细胞定位和功能方面
Cheryl S Watson,Rebecca A Alyea,Bridget E Hawkins et al.
Cheryl S Watson et al.
Background: The effects of estrogens on dopamine (DA) transport may have important implications for the increased incidence of neurological disorders in women during life stages when hormonal fluctuations are prevalent, e...
Tyrosine-specific MAPK phosphatases and the control of ERK signaling in PC12 cells [0.03%]
泰胺特特异性的MAP激酶磷酸酶与ERK信号在PC12细胞中的传递控制
Yvet E Noordman,Patrick A M Jansen,Wiljan J A J Hendriks
Yvet E Noordman
Background: Spatio-temporal control of extracellular signal-regulated kinase (ERK) activity, a critical determinant of the cell's response to growth factors, requires timely dephosphorylation of its regulatory tyrosine an...
Yeast Ste2 receptors as tools for study of mammalian protein kinases and adaptors involved in receptor trafficking [0.03%]
酿酒酵母Ste2受体研究哺乳动物蛋白激酶和受体转运相关衔接蛋白的功能及机制
Dezhong Yin,Elena Shumay,Hsien-Yu Wang et al.
Dezhong Yin et al.
Background: Mammalian receptors that couple to effectors via heterotrimeric G proteins (e.g., beta 2-adrenergic receptors) and receptors with intrinsic tyrosine kinase activity (e.g., insulin and IGF-I receptors) constitu...
Differential partitioning of Galphai1 with the cellular microtubules: a possible mechanism of development of Taxol resistance in human ovarian carcinoma cells [0.03%]
人卵巢癌细胞中微管依赖的Galphai1差异分布：Taxol耐药性发展的可能机制
Hemant K Parekh,Mahesha Adikari,Bharathi Vennapusa
Hemant K Parekh
Background: Taxol binds to the cellular microtubules and suppresses their dynamic instability. Development of tumor cell resistance to taxol is typically associated with increased expression of the drug efflux pump P-glyc...
An open access journal of molecular signaling: a critical need at a critical time [0.03%]
一本关于分子信号的开放存取期刊：在关键时期亟需的一项关键工作
Danny N Dhanasekaran
Danny N Dhanasekaran
Molecular signaling is an exponentially growing field that encompasses different molecular aspects of cell signaling underlying normal and pathological conditions. This area also focuses on defining the genetic and epigenetic changes that m...