Mutations on the Switch III region and the alpha3 helix of Galpha16 differentially affect receptor coupling and regulation of downstream effectors [0.03%]
Switch III区和Gα16的α3螺旋上的突变通过不同的方式影响受体偶联以及下游效应物的调节
May Ym Yu,Maurice Kc Ho,Andrew Mf Liu et al.
May Ym Yu et al.
Background: Galpha16 can activate phospholipase Cbeta (PLCbeta) directly like Galphaq. It also couples to tetratricopeptide repeat 1 (TPR1) which is linked to Ras activation. It is unknown whether PLCbeta and TPR1 interac...
Wnt and Frizzled RNA expression in human mesenchymal and embryonic (H7) stem cells [0.03%]
人源间充质干细胞和胚胎(H7)干细胞中Wnt及Frizzled家族RNA表达谱分析
Ujunwa C Okoye,Craig C Malbon,Hsien-Yu Wang
Ujunwa C Okoye
Background: Wnt signals are important for embryonic stem cells renewal, growth and differentiation. Although 19 Wnt, 10 Frizzled genes have been identified in mammals, their expression patterns in stem cells were largely ...
Dan A Liebermann,Barbara Hoffman
Dan A Liebermann
Gadd45 genes have been implicated in stress signaling in response to physiological or environmental stressors, which results in cell cycle arrest, DNA repair, cell survival and senescence, or apoptosis. Evidence accumulated implies that Gad...
The neurotransmitter dopamine modulates vascular permeability in the endothelium [0.03%]
多巴胺通过内皮细胞作用调节血管通透性
Resham Bhattacharya,Sutapa Sinha,Su-Ping Yang et al.
Resham Bhattacharya et al.
Background: Vascular permeability factor/Vascular endothelial growth factor (VPF/VEGF), a multifunctional cytokine, is a potent inducer of vascular permeability, an important early step in angiogenesis. It is known that t...
CK2beta gene silencing increases cell susceptibility to influenza A virus infection resulting in accelerated virus entry and higher viral protein content [0.03%]
沉默CK2beta基因通过加速流感病毒进入和增加子代病毒蛋白含量来增强细胞对甲型流感病毒的易感性
Henju Marjuki,Christoph Scholtissek,Hui-Ling Yen et al.
Henju Marjuki et al.
Background: Influenza A virus (IVA) exploits diverse cellular gene products to support its replication in the host. The significance of the regulatory (beta) subunit of casein kinase 2 (CK2beta) in various cellular mechan...
Regulation of thymus-dependent and thymus-independent production of immunoglobulin G subclasses by Galpha12 and Galpha13 [0.03%]
Gα12和Gα13调节胸腺依赖性和胸腺非依赖性免疫球蛋白G亚类的产生
Song Jin Lee,Woo Hyung Lee,Chang Ho Lee et al.
Song Jin Lee et al.
Background: A previous study from this laboratory showed that Galpha12 members participate in the production of inflammatory cytokines. In spite of the identification of B cell homeostasis responses regulated by Galpha13,...
Data-driven modeling of cellular stimulation, signaling and output response in RAW 264.7 cells [0.03%]
基于数据的建模：RAW264.7细胞刺激、信号转导和输出反应
Yang Wu,Gary L Johnson,Shawn M Gomez
Yang Wu
Background: Understanding the relative importance of signaling pathway components which regulate a specific cellular response is a major focus of current efforts in biology. This interest, along with the inherit complexit...
SFRP-4 abrogates Wnt-3a-induced beta-catenin and Akt/PKB signalling and reverses a Wnt-3a-imposed inhibition of in vitro mammary differentiation [0.03%]
SFRP-4能够消除Wnt-3a诱导的β连环素和Akt/PKB信号转导并逆转Wnt-3a在体外对乳腺分化的影响
Thecla Constantinou,Fabrizio Baumann,Markus D Lacher et al.
Thecla Constantinou et al.
Background: Conserved Wnt ligands are critical for signalling during development; however, various factors modulate their activity. Among these factors are the Secreted Frizzled-Related Proteins (SFRP). We previously isol...
Enhanced catharanthine and vindoline production in suspension cultures of Catharanthus roseus by ultraviolet-B light [0.03%]
紫外光-B辐射强化长春瑞滨和长春地辛在夹竹桃悬浮培养细胞中的生物合成
Shilpa Ramani,Chelliah Jayabaskaran
Shilpa Ramani
Suspension cultures of Catharanthus roseus were used to evaluate ultraviolet-B (UV-B) treatment as an abiotic elicitor of secondary metabolites. A dispersed cell suspension culture from C. roseus leaves in late exponential phase and station...
Src homology 2 (SH2) domain containing protein tyrosine phosphatase-1 (SHP-1) dephosphorylates VEGF Receptor-2 and attenuates endothelial DNA synthesis, but not migration* [0.03%]
含Src同源区2(SH2)结构域的蛋白酪氨酸磷酸酶-1通过脱磷作用使血管内皮生长因子受体-2失活，从而抑制内皮细胞DNA合成，但不影响其迁移能力
Resham Bhattacharya,Junhye Kwon,Enfeng Wang et al.
Resham Bhattacharya et al.
Background: Vascular endothelial growth factor receptor-2 (VEGFR-2, KDR), a receptor tyrosine kinase, regulates mitogenic, chemotactic, hyperpermeability, and survival signals in vascular endothelial cells in response to ...