Mutations on the Switch III region and the alpha3 helix of Galpha16 differentially affect receptor coupling and regulation of downstream effectors
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Background: Galpha16 can activate phospholipase Cbeta (PLCbeta) directly like Galphaq. It also couples to tetratricopeptide repeat 1 (TPR1) which is linked to Ras activation. It is unknown whether PLCbeta and TPR1 interact with t... ...
