A novel role for decadienyl-L-carnitine in pulmonary vascular remodeling and the underlying interventional mechanism of osthole [0.03%]
十二碳二烯基左卡尼丁在肺血管重塑中的新角色及欧登茋的干预机制
Yuan Li,Dongyang Han,Junjie Liu et al.
Yuan Li et al.
Background: Pulmonary hypertension (PH) is a severe pulmonary vascular disease lacking early diagnostic biomarker and effective therapeutics. Osthole has capability to alleviate pulmonary vascular remodeling targeting by ...
Daikenchuto ameliorates dextran sulfate sodium-induced acute and chronic ulcerative colitis by regulating gut microbiota-derived indoles to activate AhR signaling [0.03%]
大建中汤通过调节肠道微生物源吲哚激活AhR信号通路改善葡聚糖硫酸钠诱导的急性及慢性溃疡性结肠炎
Rui Liang,Xue Liu,Qinhua Chen et al.
Rui Liang et al.
Background: Ulcerative colitis (UC), a chronic-relapsing inflammatory disease with rising prevalence worldwide, is primarily driven by intestinal epithelial barrier dysfunction resulting from gut microbial dysbiosis and m...
Jinshui Chenfei formula alleviates SiO2-induced pulmonary fibrosis by inhibiting macrophage M2 polarization via Grb2/STAT6 in rats [0.03%]
金水沉肺汤通过抑制Grb2/STAT6信号通路介导的M2型巨噬细胞极化治疗二氧化硅所致大鼠肺纤维化
Fan Yang,Runsu Hou,Xinguang Liu et al.
Fan Yang et al.
Background: Jinshui Chenfei Formula (JCF), a proprietary Chinese medicinal prescription, has demonstrated remarkable therapeutic efficacy in treating pneumoconiosis patients. However, the precise mechanisms remain to be e...
Online real-time mass spectrometry-driven dynamic monitoring and optimal endpoint prediction schema development for herbal medicine decoction process [0.03%]
基于在线实时质谱引导的中药汤剂动态监测及终点预测模式优化研究
Junxian Wu,Liping Kang,Yutong Hua et al.
Junxian Wu et al.
Background: The decoction process of compound formulae is a critical procedure in traditional herbal medicine for reducing toxicity and preserving efficacy. However, due to the high complexity of herb ingredients and chem...
Qiming granules regulate Müller cell pyroptosis and the P2X7R/NLRP3 immune inflammatory pathway in diabetic retinopathy [0.03%]
祛明颗粒调节糖尿病视网膜病变Müller细胞焦亡及P2X7R/NLRP3免疫炎症信号通路的作用研究
Qi Zhou,Min Tang,Yaping Wang et al.
Qi Zhou et al.
Introduction: Müller cell pyroptosis and immune inflammation-induced retinal ganglion cell (RGC) damage are the core pathological markers and potential therapeutic targets for neurodegeneration in early diabetic retinopa...
Anti-cancer mechanism of traditional Chinese medicine natural products targeting ferroptosis [0.03%]
靶向铁死亡的抗肿瘤中药活性成分的作用机制研究进展
Jiying Zhou,Peiying Lu,Meiling Guo et al.
Jiying Zhou et al.
Ferroptosis is a novel iron-dependent form of programmed cell death characterized by the accumulation of lipid peroxides. Its mechanism involves the disruption of iron metabolism, imbalances in the antioxidant system, and lipid peroxidation...
Total flavonoids of Rhizoma drynariae targets NRF2-mediated anti-ferroptosis in osteoblasts to promote induced membrane osteogenesis [0.03%]
杜仲破补素通过靶向NRF2介导的成骨细胞抗铁死亡作用促进膜内成骨作用
Shuyuan Li,Dawen Yang,Zhanpeng Zeng et al.
Shuyuan Li et al.
Background: Induced membrane technique (IMT), a novel approach for reconstructing critical-size bone defect, encounters the challenge of lengthy mineralization time after bone grafting. Total flavonoids of Rhizoma drynari...
Tetrahydropalmatine alleviates cancer induced bone pain by inhibiting TRPV1-SP-mediated macrophage recruitment and promoting M2 polarization [0.03%]
tetrahydropalmatine通过抑制TRPV1-SP介导的巨噬细胞招募和促进M2极化来缓解癌症引起的骨痛
Qing Zhang,Ziyun Chen,Qingyong Yu et al.
Qing Zhang et al.
Background: Cancer-induced bone pain (CIBP) remains a debilitating clinical challenge due to its complex pathogenesis and limited therapeutic options. Tetrahydropalmatine (THP), an active alkaloid from Corydalis tuber, ha...
Based on the gut-heart axis: Polygonum capitatum improves atherosclerosis by modulating gut microbiota and TMAO, supporting MCPIP1/p53-associated endothelial protection [0.03%]
基于肠-心轴：Polygonum capitatum通过调节肠道菌群和TMAO，支持MCPIP1/p53相关内皮保护来改善动脉粥样硬化
Yunpei Wang,Weiyi Tian,Zi Ye et al.
Yunpei Wang et al.
Polygonum capitatum (PC), known as "Tou Hua Liao" (Chinese name), is an essential source of Hmong medicinal plants, which has been used for treating various human diseases. This study examined whether PC has lipid-lowering and anti-atherosc...
Phillyrin alleviates Kawasaki disease-induced lung inflammation by inhibiting platelet production through the NLRP3/IL-1β/NF-E2 signaling pathway [0.03%]
Phillyrin通过抑制NLRP3/IL-1β/NF-E2信号通路介导的血小板生成缓解川崎病所致肺部炎症
Da-Hao Mai,Xiaojie Huang,Minsi Liang et al.
Da-Hao Mai et al.
Background: The management of Kawasaki disease (KD)-associated complications, including thrombocytosis-driven lung inflammation, remains a clinical challenge, necessitating novel therapeutic exploration. Phillyrin, a prin...