Absence of Parkin Results in Atrophy of Oxidative Myofibers and Modulation of AKT and MURF1 Signaling in Middle-Aged Male Mice [0.03%]
Parkin缺失可引起中年小鼠氧化型肌纤维萎缩及AKT和MURF1信号通路的改变
Isabela Aparecida Divino,Ana Laura da Vieira-da-Silva,Marcos Vinicius Esteca et al.
Isabela Aparecida Divino et al.
Aim: This work aimed to investigate the effects of the loss of Parkin in middle-aged mice skeletal muscle, focusing on different types of myofibers and in the analysis of proteins related to protein synthesis and degradat...
Respiratory and Metabolic Effects of Active Expiration in Freely Behaving Rats [0.03%]
自由活动大鼠主动呼气的呼吸和代谢效应
Isabela P Leirão,Pedro L Katayama,Daniel B Zoccal
Isabela P Leirão
Aim: Exposure to low oxygen (hypoxia) or high carbon dioxide levels (hypercapnia) leads to a compensatory increase in pulmonary ventilation. Among the motor changes supporting the respiratory responses is the recruitment ...
Desiree Loreth,Wiebke Sachs,Catherine Meyer-Schwesinger
Desiree Loreth
Aim: Podocytes, highly specialized epithelial cells located in the glomerulus of the kidney, are essential to the filtration barrier that ensures separation of blood and urine. These cells exhibit a unique architecture, c...
Skeletal Muscle Fatigue in Rats Is More Consistently Related to Increased Inorganic Phosphate Concentration Than Acidosis [0.03%]
大鼠骨骼肌疲劳与无机磷酸盐浓度的增加关系较酸中毒更密切
Matthew T Lewis,Fabio G Laginestra,Jesse C Craig et al.
Matthew T Lewis et al.
Aim: Distinguish the relative importance of intramuscular acidosis (hydrogen ion) and inorganic phosphate in skeletal muscle fatigue in vivo in rats. Meth...
Activation of the Carotid Sinus Nerve After Acute Myocardial Infarction in a Cardiorenal Syndrome Type 1 Model in Sprague-Dawley Rats [0.03%]
Sprague-Dawley大鼠1型 cardiorenal syndrome 模型急性心肌梗死后颈总动脉窦神经的激活
Rollssman de Oliveira Cavalheiro,Fernanda Brognara,Carlos Alberto Aguiar da Silva et al.
Rollssman de Oliveira Cavalheiro et al.
Aim: To evaluate the effect of carotid sinus nerve stimulation (CSNS) in the progression of cardiorenal syndrome type 1 (CRS1), 3 days after acute myocardial infarction (AMI). ...
Emerging Roles of Protein O-GlcNAcylation in Bone Remodeling: New Insights Into Osteoporosis [0.03%]
蛋白质O-GlcNAc酰化的骨代谢新角色及其在骨质疏松症中的作用初探
Jinpeng Wang,Site Xu,Yuchuan Xue et al.
Jinpeng Wang et al.
Background: Bone is a dynamic tissue undergoing constant remodeling mediated by osteoblasts and osteoclasts. An imbalance between these cells can lead to reduced bone mass, disrupted microarchitecture, and ultimately oste...
Christian Bohr. Discoverer of Homotropic and Heterotopic Allostery: Periods Leading up to Bohr's Life, Work, and Beyond. Was Bohr a Vitalist and Right About a "Specific Activity"? [0.03%]
克里斯蒂安·博尔。同otropic和异拓性变构效应的发现者：博尔生平及其工作前后的故事。博尔是一位活力论者吗？他对“特定活性”的看法正确吗？
Niels Bindslev
Niels Bindslev
This essay recounts and revisits the scientific contributions of Christian Bohr, highlighting his pivotal role in discovering allostery about 120 years ago. Bohr's meticulous experimentation led to identifying two distinct forms of alloster...
Mitochondrial Dysfunction and Defects in Mitochondrial Adaptation to Exercise Training in the Muscle of Patients With COPD: Disease Versus Disuse [0.03%]
慢性阻塞性肺疾病患者肌肉线粒体功能障碍及运动训练适应缺陷：疾病所致还是废用所致？
Aldjia Abdellaoui,Farés Gouzi,Cécile Notarnicola et al.
Aldjia Abdellaoui et al.
Aim: Chronic obstructive pulmonary disease (COPD) is frequently associated with skeletal muscle dysfunction, having a considerable impact on exercise tolerance and patient prognosis. Mitochondria play a role in skeletal m...
Loss of Na+,HCO3 --Cotransporter NBCn1 Inhibits Net Acid Extrusion in the Atria and Causes Hypertension-Associated Cardiac Hypertrophy [0.03%]
钠离子、碳酸氢根共转运体NBCn1丢失抑制心房净酸外排并导致高血压相关性心脏肥大
María S Espejo,Alejandro Orlowski,Trine M Sørensen et al.
María S Espejo et al.
Aim: Metabolic disturbances challenge pH homeostasis in cardiomyocytes. The electroneutral Na+,HCO3 --cotransporter NBCn1/Slc4a7 mediates net acid extrusion, and genetic variation in SLC4A7 contributes to human hypertensi...
Marina A Heuschkel,Armand Jaminon,Steffen Gräber et al.
Marina A Heuschkel et al.
Aim: Vascular calcification (VC), a characteristic feature of peripheral artery disease in patients with diabetes and chronic kidney disease, has been associated with poor prognosis. We hypothesize that hyperglycemia driv...