Impaired Renal Base Excretion in Secretin Receptor Knock-Out Mice During Prolonged Base-Loading [0.03%]
分泌素受体敲除小鼠在长时间碱性物质负荷下的肾碱性排泄功能受损
Tobias Jensen,Jesper Frank Andersen,Laura Woidemann Trans et al.
Tobias Jensen et al.
Aim: Secretin was recently found to play a pivotal role in the renal adaptation to acute base excess. Here, secretin increases pendrin-dependent HCO3 - secretion from the beta-intercalated cells in the cortical collecting...
From the Perspective of the Peripheral Sensory Nervous System: The Role of Vitamin D in Neurogenic Inflammatory Skin Disorders [0.03%]
从周围感觉神经系统角度看维甲酸D在神经源性炎症皮肤病中的作用
Sarah A Commaroto,Richard D Granstein
Sarah A Commaroto
Vitamin D (VD) is a secosteroid hormone with critical physiologic roles in calcium homeostasis and bone mineralization. Recently, studies have uncovered VD's broader effects on immune system and nervous system function. VD receptors (VDRs) ...
Meihan Guo,David Montero
Meihan Guo
Human Islet miR-199a-5p and miR-214-3p Associate With Donor Age, BMI, and Sex and Mediate Cellular Aging in Islet-Derived Cells [0.03%]
人胰岛miR-199a-5p和miR-214-3p与供者年龄、BMI及性别相关，并介导胰岛衍生细胞的衰老现象
Wilson K M Wong,Isabelle El-Azzi,Aditya Nachanekar et al.
Wilson K M Wong et al.
Objectives: Human islets are widely researched to understand pathophysiological mechanisms leading to diabetes. Sex, age, and body mass index (BMI) are key donor traits influencing islet function, which is also regulated ...
Renal Phosphate Reabsorption in Humans Depends on at Least Three Distinct Transporters Unlike in Mice [0.03%]
人体的肾磷酸盐回吸收依赖于至少三种不同的转运蛋白而非像小鼠一样只有两种
Ashley L Fernandes,Laurine Lang,Jürgen Klar et al.
Ashley L Fernandes et al.
Aim: Kidney excretion of phosphate is the gatekeeper of systemic phosphate homeostasis as evident from inborn and acquired diseases. Renal phosphate transporters are a promising target for phosphate-lowering drugs, but mo...
Under Control? Mouse Models of Heat Exposure: A Systematic Review of Experimental Design and Methodology [0.03%]
可控？小鼠热暴露实验模型的系统性回顾：实验设计与方法学分析
Amina H Rhaman,Leaf R Kardol,Shane K Maloney et al.
Amina H Rhaman et al.
Mouse models are widely used to study heat-related physiological responses as they provide insights relevant to human health. However, species differences (including nocturnal behavior) and standard housing below the thermoneutral zone (TNZ...
Disruption of Claudin-2 and Trpv6 Results in Hypocalcemia, Hypercalciuria, and Altered Bone Microarchitecture in Mice [0.03%]
Claudin-2和Trpv6受损会导致小鼠低钙血症、高钙尿症及骨微结构改变
Harneet Kaur Bhullar,Amanda Lima Deluque,Debbie D O&#x;Neil et al.
Harneet Kaur Bhullar et al.
Transepithelial calcium absorption occurs via a transcellular or paracellular pathway. The intestinal transcellular pathway relies, at least partially, on the apical calcium channel transient receptor potential vanilloid 6 (TRPV6), whereas ...
P2X7-NEK7-NLRP3 Axis Drives Cardiac Inflammation and Fibrosis in Isoproterenol-Induced Cardiac Remodeling in Mice [0.03%]
异丙肾上腺素诱导的小鼠心脏重塑中P2X7-NEK7-NLRP3轴驱动心脏炎症和纤维化
Aline Cristina Parletta,Gabriela Cavazza Cerri,Marina Fevereiro et al.
Aline Cristina Parletta et al.
Aim: Cardiac remodeling (CR) is a critical risk factor for the development and progression of cardiovascular diseases. CR is accompanied by activation of the innate immune response, with NLRP3 inflammasome emerging as a k...
Mitoquinone Prevents Cardiac Dysfunction by Normalizing Mitochondrial ROS and Calcium Handling in Acute Myocardial Infarction [0.03%]
左心室急性心肌梗死后线粒体ROS和钙稳态异常及其对心脏功能影响的评估：.mitoc醌在线粒体水平上通过抗氧化应激来保护心脏功能作用的研究
Carolina Falcão Ximenes,Pietra Zava Lorencini,Carmen Castardeli et al.
Carolina Falcão Ximenes et al.
Acute myocardial infarction (MI) is the leading cause of heart failure (HF). However, the role of mitochondrial ROS (ROSm) in early MI dysfunction remains unclear. This study aimed to evaluate the impact of MitoQ on cardiac function in case...
Differential Myopathic and Transcriptomic Changes in Soleus and Gastrocnemius Muscles in a Novel Chronic Hindlimb Ischemia Rat Model Induced by Endovascular Catheter Occlusion [0.03%]
新型慢性下肢缺血大鼠模型内血管插管阻塞诱导的比目鱼肌和腓肠肌肌病和转录组变化的差异性研究
Oliver Kitzerow,Zhiqiu Xia,Samuel Gillman et al.
Oliver Kitzerow et al.
Peripheral artery disease (PAD) is a progressive atherothrombotic disorder affecting more than 230 million people worldwide. Conventional animal models of chronic hindlimb ischemia (HLI) are highly invasive, technically challenging, fail to...