Loss of Na+,HCO3 --Cotransporter NBCn1 Inhibits Net Acid Extrusion in the Atria and Causes Hypertension-Associated Cardiac Hypertrophy
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Aim: Metabolic disturbances challenge pH homeostasis in cardiomyocytes. The electroneutral Na+,HCO3 --cotransporter NBCn1/Slc4a7 mediates net acid extrusion, and genetic variation in SLC4A7 contributes to human hypertension and c... ...
