Promiscuous and lineage-specific roles of cell cycle regulators in haematopoiesis [0.03%]
细胞周期调节因子在造血中的多效性和系谱特异性作用
Stephen S Myatt,Eric W-F Lam
Stephen S Myatt
Haematopoietic cell number is maintained by a delicate balance between cell proliferation, differentiation and death. Gene knockout studies in mice have revealed the complex roles of cyclins, CDKs, and CDK inhibitors in regulating cell prol...
Stealing the spotlight: CUL4-DDB1 ubiquitin ligase docks WD40-repeat proteins to destroy [0.03%]
夺人眼球：CUL4-DDB1泛素连接酶招募WD40重复蛋白促其降解
Leigh Ann Higa,Hui Zhang
Leigh Ann Higa
Recent investigation of Cullin 4 (CUL4) has ushered this class of multiprotein ubiquitin E3 ligases to center stage as critical regulators of diverse processes including cell cycle regulation, developmental patterning, DNA replication, DNA ...
How eggs arrest at metaphase II: MPF stabilisation plus APC/C inhibition equals Cytostatic Factor [0.03%]
卵子在第二中期停留的机制：MPF稳定化加APC/C抑制等于细胞静止因子作用
Suzanne Madgwick,Keith T Jones
Suzanne Madgwick
Oocytes from higher chordates, including man and nearly all mammals, arrest at metaphase of the second meiotic division before fertilization. This arrest is due to an activity that has been termed 'Cytostatic Factor'. Cytostatic Factor main...
Sofia Francia,Robert S Weiss,Fabrizio d&#x;Adda di Fagagna
Sofia Francia
"Natura non facit saltum" (nature makes no leap) the Latins used to say, meaning that nature does not like discontinuities. Cells make no exception and indeed any discontinuity in the DNA double helix is promptly detected, triggering an alt...
SCF Fbx4/alphaB-crystallin cyclin D1 ubiquitin ligase: a license to destroy [0.03%]
SCF(Fbx4/αB-晶体蛋白)Dyclin D1泛素连接酶：降解许可证书
Olena Barbash,Douglas I Lin,J Alan Diehl
Olena Barbash
Cyclin D1 is an allosteric regulator for cyclin-dependent kinases 4 and 6 (CDK4/6). The cyclin D/CDK4 kinase promotes G1/S transition through the posttranslational modification and the subsequent inactivation of the retinoblastoma (Rb) prot...
Editorial
Cell division. 2007 Jan 15:2:2. DOI:10.1186/1747-1028-2-2 2007
MAP kinase meets mitosis: a role for Raf Kinase Inhibitory Protein in spindle checkpoint regulation [0.03%]
MAP激酶与有丝分裂的交汇：Raf激酶抑制蛋白在检查点调节中的作用
Marsha Rich Rosner
Marsha Rich Rosner
Raf Kinase Inhibitory Protein (RKIP) is an evolutionarily conserved protein that functions as a modulator of signaling by the MAP kinase cascade. Implicated as a metastasis suppressor, Raf Kinase Inhibitory Protein depletion correlates with...
Variations in cyclin D1 levels through the cell cycle determine the proliferative fate of a cell [0.03%]
细胞周期中cyclin D1水平的差异决定了细胞的命运
Ke Yang,Masahiro Hitomi,Dennis W Stacey
Ke Yang
We present evidence that variations in cyclin D1 levels through the cell cycle are essential for continuing proliferation. Cyclin D1 levels must be high during G1 phase for a cell to initiate DNA synthesis, but then must be suppressed to lo...
Eg5 steps it up! [0.03%]
第五元素
Megan T Valentine,Polly M Fordyce,Steven M Block
Megan T Valentine
Understanding how molecular motors generate force and move microtubules in mitosis is essential to understanding the physical mechanism of cell division. Recent measurements have shown that one mitotic kinesin superfamily member, Eg5, is me...
Damien Hermand
Damien Hermand
Regulation of protein stability through the ubiquitin proteasome system is a key mechanism underlying numerous cellular processes. The ubiquitin protein ligases (or E3) are in charge of substrate specificity and therefore play a pivotal rol...
Editorial
Cell division. 2006 Dec 13:1:30. DOI:10.1186/1747-1028-1-30 2006
Regulation of germline stem cell proliferation downstream of nutrient sensing [0.03%]
营养感应下游生殖干细胞增殖的调节
Patrick Narbonne,Richard Roy
Patrick Narbonne
Stem cells have recently attracted significant attention largely due to their potential therapeutic properties, but also because of their role in tumorigenesis and their resemblance, in many aspects, to cancerous cells. Understanding how st...