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SCF Fbx4/alphaB-crystallin cyclin D1 ubiquitin ligase: a license to destroy

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Cyclin D1 is an allosteric regulator for cyclin-dependent kinases 4 and 6 (CDK4/6). The cyclin D/CDK4 kinase promotes G1/S transition through the posttranslational modification and the subsequent inactivation of the retinoblastoma (Rb) protein and related fami... ...