NSUN2 regulates PARP9 progression through m5C modification to mediate breast cancer progression [0.03%]
NSUN2通过m5C修饰调节PARP9介导乳腺癌进展
Xin Li,Changjiao Yan,Jun Yi et al.
Xin Li et al.
Background: m5C modification plays a vital role in the progression of human cancers, including breast cancer (BC), but the function of NOP2/Sun RNA methyltransferase 2 (NSUN2), an RNA m5C modification enzyme, remains larg...
The roles and clinical significance of LINC01140 in human cancers in the real world [0.03%]
LINC01140在人类癌症中的作用及临床意义
Wen-Jing Men,Xiang-Sheng Wen
Wen-Jing Men
Carcinogenic factors facilitate cell carcinogenesis and the progression of cancer. In contrast, tumor suppressor factors inhibit abnormal cell proliferation and cancer development. Accumulating evidence indicates that long non-coding RNAs (...
Transcription factor FOXA1 suppresses ferroptosis of cervical cancer cells by upregulating SLC7A11 expression [0.03%]
转录因子FOXA1通过上调SLC7A11的表达抑制宫颈癌细胞铁死亡
Fei Gao,Yan Zeng,Li Jia et al.
Fei Gao et al.
Ferroptosis, a unique modality of cell death, possesses critical activity in tumorigenesis. This study defined the role of transcription factor (TF) forkhead box A1 (FOXA1) in modulating ferroptosis of cervical cancer (CC), a prevalent dise...
p53 overexpression counteracts the pro-survival effect of Bcl-2 by restoring MAMs function in cutaneous squamous cell carcinoma [0.03%]
p53过表达通过恢复膜周边结构的功能来对抗Bcl-2对皮肤鳞状细胞癌的促生存效应
Yupeng Huang,Jing Liu,Xiao Shao et al.
Yupeng Huang et al.
Background: Cutaneous squamous cell carcinoma (cSCC) is a prevalent type of skin cancer, and its development is strongly associated with impaired regulation of apoptosis. The anti-apoptotic protein B-cell lymphoma 2 (Bcl-...
Esculentoside A suppresses the malignant progression of hepatocellular carcinoma by promoting RORB [0.03%]
esculentoside A通过促进RORR介导的代谢和表观遗传重编程抑制肝细胞癌的恶性进展
Qing Ye,Dousheng Bai,Aoqing Wang et al.
Qing Ye et al.
Hepatocellular carcinoma (HCC) is a highly aggressive disease associated with a poor prognosis. The present study attempts to discover the potential of esculentoside A (EsA) in inhibiting HCC progression. Cell viability was assessed using t...
Linalool targets NR3C2 to inhibit NF-κB-mediated gastric cancer progression [0.03%]
香芹酚通过靶向糖皮质激素受体NR3C2抑制胃癌中NF-κB介导的癌症进程
Ying Hu,Shunfeng Chen,Yu Wang et al.
Ying Hu et al.
Gastric cancer (GC) is a major global health challenge. This study explores the efficacy of linalool in GC and further elucidates its underlying mechanisms. Linalool inhibited the proliferation, migration, and invasion of GC cells and preve...
The adipogenesis-related gene CEBPD as a prognostic biomarker and functional tumor suppressor in breast cancer [0.03%]
CCAAT/增强子结合蛋白同源物CEBPD作为乳腺癌预后生物标志物和功能型抑癌基因的作用研究
Shuang Qiu,Xin Chen,Jinyu Yang et al.
Shuang Qiu et al.
This study explores the role of adipogenesis-related genes (ARGs) in breast cancer, focusing on CEBPD, a key gene linked to adipogenesis. Using the TCGA-BRCA dataset, differentially expressed ARGs (DARGs) were identified, revealing 26 upreg...
PTTG1-mediated the transcription of c-myc promotes retinoblastoma progression [0.03%]
PTTG1介导的c-myc转录促进视网膜母细胞瘤进展
Junli Feng,Yunpeng Ye,Furong Cheng et al.
Junli Feng et al.
Purpose: The oncogenic potential of pituitary tumor-transforming gene-1 (PTTG1) has been well-documented in multiple cancer types. This study explored the biological role and molecular mechanism of PTTG1 in retinoblastoma...
Role of cadherin gene dysregulation in WNT signaling and nasopharyngeal carcinoma [0.03%]
基底膜下层粘附分子基因调控在鼻咽癌中的作用研究
Wenfeng Yao,Litao Qin,Qian Li et al.
Wenfeng Yao et al.
Background: Nasopharyngeal carcinoma (NPC) is a malignancy associated with genetic alterations and tumor progression. Cadherin genes (CDH1, CDH2, and CDH3) play key roles in cell adhesion, migration, and tissue integrity,...
Overexpression of ENDOD1 inhibits proliferation, migration, and invasion of colorectal cancer [0.03%]
ENDOD1过表达抑制结直肠癌的增殖、迁移和侵袭
Yichi Zhang,Nijina Li,Hao Zhang et al.
Yichi Zhang et al.