The role of CDK in the initiation step of DNA replication in eukaryotes [0.03%]
CDK在真核生物DNA复制起始步骤中的作用
Seiji Tanaka,Yon-Soo Tak,Hiroyuki Araki
Seiji Tanaka
Cyclin-dependent kinases (CDKs) regulate the progression of the cell cycle in eukaryotes. One of the major roles of CDK is to promote chromosomal DNA replication. However, how CDKs promote DNA replication has been a long-standing question, ...
Shyam K Sharan,Sergey G Kuznetsov
Shyam K Sharan
DNA double strand breaks are efficiently repaired by homologous recombination. One of the last steps of this process is resolution of Holliday junctions that are formed at the sites of genetic exchange between homologous DNA. Although vario...
Editorial
Cell division. 2007 Jun 4:2:15. DOI:10.1186/1747-1028-2-15 2007
Ayami Ohtaka,Takamune T Saito,Daisuke Okuzaki et al.
Ayami Ohtaka et al.
Many meiosis-specific proteins in Schizosaccharomyces pombe contain coiled-coil motifs which play essential roles for meiotic progression. For example, the coiled-coil motifs present in Meu13 and Mcp7 are required for their function as a pu...
Irina Nickeleit,Steffen Zender,Uta Kossatz et al.
Irina Nickeleit et al.
The cyclin kinase inhibitor p27kip1 acts as a potent tumor supressor protein in a variety of human cancers. Its expression levels correlate closely with the overall prognosis of the affected patient and often predict the outcome to differen...
Jennifer A Perry,Sally Kornbluth
Jennifer A Perry
Movement through the cell cycle is controlled by the temporally and spatially ordered activation of cyclin-dependent kinases paired with their respective cyclin binding partners. Cell cycle events occur in a stepwise fashion and are monitor...
Tanja Woelk,Sara Sigismund,Lorenza Penengo et al.
Tanja Woelk et al.
Ubiquitin is a highly versatile post-translational modification that controls virtually all types of cellular events. Over the past ten years we have learned that diverse forms of ubiquitin modifications and of ubiquitin binding modules co-...
Irreversibility of cellular senescence: dual roles of p16INK4a/Rb-pathway in cell cycle control [0.03%]
细胞衰老的不可逆性：“p16INK4a/Rb途径”在控制细胞周期中的双重作用
Akiko Takahashi,Naoko Ohtani,Eiji Hara
Akiko Takahashi
The retinoblastoma (Rb) tumor suppressor gene product, pRb, has an established role in the implementation of cellular senescence, the state of irreversible G1 cell cycle arrest provoked by diverse oncogenic stresses. In murine cells, senesc...
Editorial
Cell division. 2007 Mar 7:2:10. DOI:10.1186/1747-1028-2-10 2007
FBXW7/hCDC4 controls glioma cell proliferation in vitro and is a prognostic marker for survival in glioblastoma patients [0.03%]
FBXW7/ hCDC4调控胶质瘤细胞的体外增殖并且是多形性胶质母细胞瘤患者的预后标志物
Martin Hagedorn,Maylis Delugin,Isabelle Abraldes et al.
Martin Hagedorn et al.
Background: In the quest for novel molecular mediators of glioma progression, we studied the regulation of FBXW7 (hCDC4/hAGO/SEL10), its association with survival of patients with glioblastoma and its potential role as a ...
Umasundari Sivaprasad,Yuichi J Machida,Anindya Dutta
Umasundari Sivaprasad
DNA replication must be tightly controlled to prevent initiation of a second round of replication until mitosis is complete. So far, components of the pre-replicative complex (Cdt1, Cdc6 and geminin) were considered key players in this regu...
Markus Welcker,Bruce E Clurman
Markus Welcker
Background: The Fbw7 ubiquitin ligase promotes the rapid degradation of several important oncogenes, such as cyclin E, c-Myc, c-Jun, and Notch. The two fission yeast homologs of Fbw7, pop1 and pop2, have previously been s...