Irreversibility of cellular senescence: dual roles of p16INK4a/Rb-pathway in cell cycle control
{{output}}
The retinoblastoma (Rb) tumor suppressor gene product, pRb, has an established role in the implementation of cellular senescence, the state of irreversible G1 cell cycle arrest provoked by diverse oncogenic stresses. In murine cells, senescence cell cycle arre... ...
