Structure-function analysis of the retinoblastoma tumor suppressor protein - is the whole a sum of its parts? [0.03%]
视网膜母细胞瘤肿瘤抑制蛋白的结构与功能分析-整体就是各部分之和吗？
Frederick A Dick
Frederick A Dick
Biochemical analysis of the retinoblastoma protein's function has received considerable attention since it was cloned just over 20 years ago. During this time pRB has emerged as a key regulator of the cell division cycle and its ability to ...
Laura O&#x;regan,Joelle Blot,Andrew M Fry
Laura O&#x;regan
The NIMA-related kinases represent a family of serine/threonine kinases implicated in cell cycle control. The founding member of this family, the NIMA kinase of Aspergillus nidulans, as well as the fission yeast homologue Fin1, contribute t...
Fez1/Lzts1 a new mitotic regulator implicated in cancer development [0.03%]
Fez1/Lzts1新的有丝分裂调控因子与癌症发生有关
Andrea Vecchione,Carlo M Croce,Gustavo Baldassarre
Andrea Vecchione
Considerable evidence has accumulated suggesting that cancer has genetic origin, based on the development of genomic alterations, such as deletions, mutations, and/or methylations in critical genes for homeostasis of cellular functions, inc...
Running on a treadmill: dynamic inhibition of APC/C by the spindle checkpoint [0.03%]
奔跑在跑步机上——动力学抑制APC/C的检查点机制
Laura A Díaz-Martínez,Hongtao Yu
Laura A Díaz-Martínez
During mitosis, the genome duplicated during S-phase is synchronously and accurately segregated to the two daughter cells. The spindle checkpoint prevents premature sister-chromatid separation and mitotic exit. The anaphase-promoting comple...
Editorial
Cell division. 2007 Jul 24:2:23. DOI:10.1186/1747-1028-2-23 2007
MIF coordinates the cell cycle with DNA damage checkpoints. Lessons from knockout mouse models [0.03%]
MIF与DNA损伤检查点协调细胞周期。敲除小鼠模型带来的启示
Günter Fingerle-Rowson,Oleksi Petrenko
Günter Fingerle-Rowson
Macrophage migration inhibitory factor (MIF) is a ubiquitously expressed pro-inflammatory mediator that has also been implicated in the process of oncogenic transformation and tumor progression. We used a genetic approach to show that delet...
The anti-apoptotic factor Che-1/AATF links transcriptional regulation, cell cycle control, and DNA damage response [0.03%]
转录调节、细胞周期调控和DNA损伤反应的抗凋亡因子Che-1/AATF
Claudio Passananti,Maurizio Fanciulli
Claudio Passananti
Che-1 is a RNA polymerase II binding protein involved in the transcriptional regulation of E2F target genes and in cell proliferation. Recently, it has been shown that Che-1 accumulates in cells responding to genotoxic agents such as Doxoru...
Editorial
Cell division. 2007 Jul 16:2:21. DOI:10.1186/1747-1028-2-21 2007
Bradley S Ellison,Mary Kb Zanin,Robert J Boackle
Bradley S Ellison
Background: Membrane complement regulatory proteins (mCRPs) inhibit complement-mediated killing of human cells by human complement, a property that confers protection from complement to malignant breast cancer cells and t...
Jordi Torres-Rosell,Giacomo De Piccoli,Luis Aragón
Jordi Torres-Rosell
Completion of DNA replication before mitosis is essential for genome stability and cell viability. Cellular controls called checkpoints act as surveillance mechanisms capable of detecting errors and blocking cell cycle progression to allow ...
Cdt1 degradation to prevent DNA re-replication: conserved and non-conserved pathways [0.03%]
调控CDT1降解以防止DNA再复制：保守途径与非保守途径
Youngjo Kim,Edward T Kipreos
Youngjo Kim
In eukaryotes, DNA replication is strictly regulated so that it occurs only once per cell cycle. The mechanisms that prevent excessive DNA replication are focused on preventing replication origins from being reused within the same cell cycl...
Haruhiko Asakawa,Tokuko Haraguchi,Yasushi Hiraoka
Haruhiko Asakawa
In eukaryotic organisms, chromosomes are spatially organized within the nucleus. Such nuclear architecture provides a physical framework for the genetic activities of chromosomes, and changes its functional organization as the cell moves th...