Lin-Yu Lu,Xiaochun Yu
Lin-Yu Lu
Polo-like kinase 1 (Plk1) belongs to a family of conserved serine/threonine kinases with a polo-box domain, which have similar but non-overlapping functions in the cell cycle progression. Plk1 plays a key role to ensure the normal mitosis. ...
Impact of steroid hormone signals on Drosophila cell cycle during development [0.03%]
表皮源性信号对果蝇细胞周期的影响
Nicola Cranna,Leonie Quinn
Nicola Cranna
Metamorphosis of Drosophila involves proliferation, differentiation and death of larval tissues in order to form the adult fly. The major steroid hormone implicated in the larval-pupal transition and adult tissue modelling is ecdysone. Prev...
Min Li,Pumin Zhang
Min Li
The anaphase promoting complex/cyclosome (APC/C) is a multi-subunit E3 ubiquitin ligase playing essential functions in mitosis. It is conserved from yeast to human and relies on two adaptor proteins, Cdc20 and Cdh1, to bring in substrates. ...
Adam J Hume,Robert F Kalejta
Adam J Hume
Viruses are obligate intracellular parasites that alter the environment of infected cells in order to replicate more efficiently. One way viruses achieve this is by modulating cell cycle progression. The main regulators of progression out o...
Gaurisankar Sa,Tanya Das
Gaurisankar Sa
Increasing knowledge on the cell cycle deregulations in cancers has promoted the introduction of phytochemicals, which can either modulate signaling pathways leading to cell cycle regulation or directly alter cell cycle regulatory molecules...
Carl R Walkley,Vijay G Sankaran,Stuart H Orkin
Carl R Walkley
The retinoblastoma protein, Rb, was one of the first tumor suppressor genes identified as a result of the familial syndrome retinoblastoma. In the period since its identification and cloning a large number of studies have described its role...
Speeding through cell cycle roadblocks: Nuclear cyclin D1-dependent kinase and neoplastic transformation [0.03%]
穿过细胞周期路障的速度：核cyclin D1依赖性激酶与新生物形成
Laura L Pontano,J Alan Diehl
Laura L Pontano
Mitogenic induction of cyclin D1, the allosteric regulator of CDK4/6, is a key regulatory event contributing to G1 phase progression. Following the G1/S transition, cyclin D1 activation is antagonized by GSK3beta-dependent threonine-286 (Th...
The emerging regulatory potential of SCFMet30 -mediated polyubiquitination and proteolysis of the Met4 transcriptional activator [0.03%]
SCFMet30泛素化和降解Met4转录激活子的新兴调控潜能
Srikripa Chandrasekaran,Dorota Skowyra
Srikripa Chandrasekaran
The yeast SCFMet30 ubiquitin ligase plays a critical role in cell division by regulating the Met4 transcriptional activator of genes that control the uptake and assimilation of sulfur into methionine and S-adenosyl-methionine. The initial v...
The chromosomal passenger complex and the spindle assembly checkpoint: kinetochore-microtubule error correction and beyond [0.03%]
染色体乘客复合物与纺锤体组装检点：着丝粒-微管连接错配的修正及其余功能
Gerben Vader,André F Maia,Susanne Ma Lens
Gerben Vader
During mitosis, correct bipolar chromosome attachment to the mitotic spindle is an essential prerequisite for the equal segregation of chromosomes. The spindle assembly checkpoint can prevent chromosome segregation as long as not all chromo...
David Macpherson
David Macpherson
Novel murine models of retinoblastoma based on Rb gene deletion in concert with inactivation of Rb family members have recently been developed. These new Rb knockout models of retinoblastoma provide excellent tools for pre-clinical studies ...