Speeding through cell cycle roadblocks: Nuclear cyclin D1-dependent kinase and neoplastic transformation
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Mitogenic induction of cyclin D1, the allosteric regulator of CDK4/6, is a key regulatory event contributing to G1 phase progression. Following the G1/S transition, cyclin D1 activation is antagonized by GSK3beta-dependent threonine-286 (Thr-286) phosphorylat... ...
