TRIM31 promotes lenvatinib resistance and stemness in hepatocellular carcinoma through K48/K63-linked ubiquitination of GLDC [0.03%]
TRIM31通过GLDC的K48/K63连接泛素化促进肝细胞癌对仑伐替尼的耐药性和干细胞特性
Zhipeng Quan,Tingfeng Xu,Ding Liang et al.
Zhipeng Quan et al.
Hepatocellular carcinoma (HCC) is a type of cancer with a high incidence rate and a high mortality rate and is a major cause of cancer-related death. The resistance of liver cancer cells to lenvatinib has become a crucial limitation that re...
Engrailed 2 enhances neuronal differentiation of bone marrow mesenchymal stem cells to promote spinal cord injury repair [0.03%]
engrailed 2通过促进骨髓间充质干细胞向神经元分化来促进脊髓损伤修复
Hongpeng Ma,Yan Zhang,Shibo Zhu et al.
Hongpeng Ma et al.
Bone marrow mesenchymal stem cells (BMSCs) hold promise for spinal cord injury (SCI) repair, yet their limited neuronal conversion efficiency restricts therapeutic outcomes. Therefore, this study investigated the role of En2 in regulating t...
The USP46-MCM7-RAD51 axis confers oxaliplatin resistance in colon cancer by augmenting homologous recombination repair capacity [0.03%]
USP46-MCM7-RAD51轴通过增强同源重组修复能力介导结直肠癌顺铂耐药性
Changlei Wu,Wenjie Zhu,Zitao Liu et al.
Changlei Wu et al.
Chemoresistance remains a critical barrier to the efficacy of oxaliplatin in colon cancer treatment. While the deubiquitinating enzyme USP46 is implicated in multiple tumor progression pathways, its specific role in oxaliplatin resistance r...
HDAC6 promotes osimertinib resistance evolution in non-small cell lung cancer by activating EGFR degradation through the ubiquitin-proteasome pathway [0.03%]
HDAC6通过泛素-蛋白酶体途径促进EGFR降解从而诱导非小细胞肺癌产生奥希替尼耐药性
Cheng Yang,Danlei Xu,Zifang Zhu et al.
Cheng Yang et al.
Osimertinib is the standard first-line treatment for patients with non-small cell lung cancer (NSCLC) harboring EGFR-sensitive mutations. However, drug resistance inevitably develops, highlighting the critical need for strategies to overcom...
Changshun Li,Wei Jiang,Mingfang Lu
Changshun Li
Metabolic diseases, which include obesity, type 2 diabetes, atherosclerosis, and metabolic dysfunction-associated steatotic liver disease (MASLD), are significant global health challenges. Patients with these conditions frequently exhibit g...
Inhibiting BCL2L1 preferentially targets aneuploid cells in acute myeloid leukemia [0.03%]
抑制BCL2L1优先针对急性髓系白血病中的非整倍体细胞
Ya Zhao,Wenying Yu,Tingting Xie et al.
Ya Zhao et al.
Refractory acute myeloid leukemia (AML) is frequently associated with high rates of aneuploidy, a hallmark of intratumoral heterogeneity (ITH) that promotes chemoresistance and is linked to poor prognosis. ITH enables the competitive expans...
DUSP5 regulates ferroptosis in pancreatic cancer by down-regulating SCD1 expression via ERK1/2 [0.03%]
DUSP5通过ERK1/2下调SCD1表达调节胰腺癌细胞铁死亡
Zhilei Zhang,Yuming Jia,Chao Wang et al.
Zhilei Zhang et al.
Pancreatic ductal adenocarcinoma (PDAC) remains a highly lethal malignancy with limited therapeutic options. The Ras/Raf/MEK/ERK signaling pathway is critically involved in PDAC progression, yet targeting its downstream effectors remains ch...
Discovery of high-efficiency ( S)- N-methylcoclaurine 3'-hydroxylase involved in the biosynthesis of benzylisoquinoline alkaloids in Berberidaceae [0.03%]
含氮杂环衍生物生物合成中的高效(S)-N-甲基小檗碱3′-羟化酶的发现
Lingzhe Kong,Xiao He,Chenghua Gong et al.
Lingzhe Kong et al.
Benzylisoquinoline alkaloids (BIAs) represent a class of plant-derived compounds with significant pharmacological importance. The biosynthesis of most BIAs originates from a common precursor ( S)-reticuline. ( S)- N-methylcoclaurine 3'-hydr...
Ciclopirox suppresses melanoma growth by activating ER stress-driven apoptosis and disrupting Src/STAT3 signaling [0.03%]
西洛桑通过激活内质网应激驱动的凋亡和破坏Src / STAT3信号来抑制黑色素瘤生长
Ziwei Zhang,Junwan Lu,Zheng Ouyang et al.
Ziwei Zhang et al.
Ciclopirox (CPX), an FDA-approved antifungal drug, exhibits promising antitumor activity. This study investigates its efficacy and mechanisms against melanoma. Here, we find that CPX potently inhibits melanoma cell proliferation, migration,...