SOX2 transactivates NRF2 to promote carboplatin resistance in lung squamous cell carcinoma [0.03%]
SOX2通过激活NRF2促进肺鳞状细胞癌对卡铂耐药性
Hanfei Gao,Chaomei Li,Jie Sun et al.
Hanfei Gao et al.
Lung squamous cell carcinoma (LUSC) remains a major therapeutic challenge because of its pronounced resistance to chemotherapy, particularly carboplatin. In this study, we investigate the role of SOX2, a lineage-survival oncogene, in mediat...
Corrigendum to "Caveolin-1-deficient fibroblasts promote migration, invasion, and stemness by activating the TGF-β/Smad signaling pathway in breast cancer cells" [0.03%]
“ Caveolin-1缺陷型成纤维细胞通过激活乳腺癌细胞的TGF- β / Smad信号通路来促进迁移、侵袭和干性”的校正发表
Qingyun Huang,Longyuan Wu,Yi Wang et al.
Qingyun Huang et al.
Eupalinolide B exerts cytotoxic effects against KRAS-mutant NSCLC through Nrf2/HO-1-regulated ferroptosis [0.03%]
Eupalinolide B通过Nrf2/HO-1调节的铁死亡对KRAS突变型NSCLC发挥细胞毒性作用
Wenjian Wang,Jinglu Yu,Tanxuan Huang et al.
Wenjian Wang et al.
Ferroptosis, an iron-dependent form of regulated cell death, is characterized by excessive reactive oxygen species (ROS) accumulation and lipid peroxidation of polyunsaturated fatty acids (PUFAs) in cellular membranes. Non-small cell lung c...
Myocyte enhancer factor 2a orchestrates vascular redox homeostasis via direct transcriptional activation of SIRT1 [0.03%]
肌细胞增强因子2a通过直接激活SIRT1的转录来调控血管氧化还原稳态
Benrong Liu,Lei Fang,Chunxia Miao et al.
Benrong Liu et al.
Myocyte enhancer factor 2A (MEF2A), a transcription factor implicated in coronary artery disease, remains unexplored in vascular redox regulation. To address this gap and overcome the limitations of current antioxidant therapies, we investi...
Levosimendan ameliorates cardiomyocyte injury and mitochondrial dysfunction in an Nrf2-dependent manner in mice with sepsis-induced cardiomyopathy [0.03%]
乐西莫得通过Nrf2依赖性机制改善脓毒症心肌病小鼠的心肌细胞损伤和线粒体功能障碍
Xinyuan Zhu,Hongyan Zhai,Huishuang Shao et al.
Xinyuan Zhu et al.
Sepsis-induced cardiomyopathy (SIC) is a severe complication of sepsis and septic shock and is characterized by cardiac dysfunction. Levosimendan (LEVO), a calcium sensitizer, has shown therapeutic potential in SIC, although its underlying ...
COCA-seq: genome-wide mapping of O-GlcNAc-associated open chromatin [0.03%]
COCA-Seq：O-GlcNAC相关开放式染色体的全基因组绘制
Chang Ge,Ran Zhao,Hongyu Jiang et al.
Chang Ge et al.
O-GlcNAcylation, a prevalent reversible post-translational modification, intricately alters non-histone proteins, influencing the organization of gene transcriptional regulation within the accessible chromatin environment. This nucleoplasmi...
Gut microbiota circadian rhythms: a key regulator of immunometabolic homeostasis [0.03%]
肠道微生物昼夜节律：免疫代谢稳态的关键调节因子
Zitong Zhao,Siyan Wu,Tingting Wang et al.
Zitong Zhao et al.
Emerging studies have revealed that disruptions in circadian crosstalk between the gut microbiota and the host play an essential role in the pathogenesis of metabolic disorders. Under physiological conditions, host circadian clocks regulate...
Gut-brain axis and exosome-mediated communication in postoperative cognitive dysfunction associated with colorectal cancer [0.03%]
胃肠道-大脑轴线及外泌体介导的沟通在结直肠癌术后认知功能障碍中的作用
Ying Gao,Biao Xi,Yang Zhang et al.
Ying Gao et al.
Postoperative cognitive dysfunction (POCD) is a serious complication in patients undergoing colorectal cancer (CRC) surgery. It is characterized by significant impairments in memory, information processing and attention, and may also result...
Antibody-oligonucleotide conjugates for spatial proteomics: principles, applications, and challenges [0.03%]
抗体-寡核苷酸偶联物在空间蛋白质组学中的原理、应用及挑战
Yinghui Qiu,Chunlan Li,Peiying Ye et al.
Yinghui Qiu et al.
Spatial biology aims to elucidate cellular organization, function, and interactions within native tissue contexts, offering key insights into both normal physiology and disease. Spatial proteomics complements this by enabling high-resolutio...
SUN5 interacts with TRIM28, enhancing IκBα ubiquitination to promote glycolysis in colorectal cancer cells [0.03%]
SUN5通过与TRIM28相互作用增强IκBα泛素化促进结直肠癌细胞糖酵解
Jingyuan Chen,Youbo Yang,Gang Liu et al.
Jingyuan Chen et al.
Glycolysis provides the main energy source for the rapid proliferation and migration of colorectal cancer (CRC) cells. In our previous studies, we reported that SUN5, a nuclear membrane protein, promotes proliferation and migration. However...