Genetic characterization and functional analysis of novel PITX2 variants identified in Chinese families with Axenfeld-Rieger syndrome [0.03%]
中国Axenfeld-Rieger综合征家系中新型PITX2变异体的基因特征及功能分析
Junqin Xu,Xinyao Wang,Zilin Zhong et al.
Junqin Xu et al.
Structural basis for suramin binding to the C-terminal domain of the SARS-CoV-2 nucleocapsid protein [0.03%]
硫酸沙莫磷与SARS-CoV-2核衣壳蛋白C端结构域结合的结构基础
Chenyun Guo,Xiao Li,Hao Xu et al.
Chenyun Guo et al.
The global threat posed by COVID-19 persists, largely due to the high mutability of SARS-CoV-2 and the limited availability of effective antiviral therapeutics. The nucleocapsid (N) protein of SARS-CoV-2 is an attractive drug target because...
EOAI3402143 inhibits lung adenocarcinoma progression through the NF-κB/NR4A1 pathway [0.03%]
EOAI3402143通过NF-κB/NR4A1途径抑制肺腺癌进展
Jia Xu,Wenjun Liu,Li Chen et al.
Jia Xu et al.
Lung adenocarcinoma (LUAD) is currently the cancer with the highest morbidity and mortality rates in the world, and its targeted therapy, although effective, is limited in the types of targeted drugs and prone to drug resistance in treated ...
Metabolic analysis and identification of potential biomarkers of early-stage melanoma lung metastasis [0.03%]
黑色素瘤肺转移早期阶段的代谢分析及潜在生物标志物鉴定
Chunying Gu,Hongyu Liu,Guangyu Jiang et al.
Chunying Gu et al.
Tumor cells exhibit a notable ability to adapt to constantly changing microenvironments and possess distinct metabolic traits during metastasis. This study aims to establish a melanoma lung metastasis model in mice to elucidate the metaboli...
Carfilzomib triggers cardiotoxicity by suppressing SENP1-mediated deSUMOylation of DDX17 [0.03%]
卡非佐米通过抑制SENP1介导的DDX17去SUMO化诱发心毒性
Sheng Wang,Jingjing Wang,Xin Li et al.
Sheng Wang et al.
Carfilzomib (Cfz) is a second-generation proteasome inhibitor approved for the treatment of relapsed/refractory multiple myeloma (RRMM). Previous studies have shown that Cfz is associated with a higher incidence of severe adverse cardiac ef...
Inhibition of vascular intimal hyperplasia by the myokine Musclin: the role of NPR3/raptor/mTORC1-mediated glycolysis and phenotypic switching of VSMCs [0.03%]
肌源性肽Musclin通过NPR3/raptor/mTORC1介导的糖酵解和血管平滑肌细胞表型转换抑制血管内膜增生的作用机制研究
Shanwu Wei,Mi Xiong,De Li et al.
Shanwu Wei et al.
Skeletal muscle-derived Musclin exerts multiple effects on the cardiovascular system. However, the role of Musclin in vascular intimal hyperplasia (IH) remains unclear. This study aims to investigate the role and underlying mechanism of Mus...
Establishment and evaluation of a stable CHO cell line in which the nanobody PD-L1-Fc gene is precisely targeted into the C12orf35 locus [0.03%]
一种精确插入PD-L1-Fc基因至C12orf35位点的CHO细胞株的构建与鉴定
Feng Chang,Chen Zhang,Yu Feng et al.
Feng Chang et al.
The dual role of whole-genome duplication: biological mechanisms, functional consequences, and detection advances [0.03%]
全基因组复制的双重作用：生物学机制、功能影响及检测进展
Yawei Song,Jiajie Yang,Shuheng Wu et al.
Yawei Song et al.
Whole-genome duplication (WGD) represents an evolutionarily conserved process occurring in prokaryotes, eukaryotes, and somatic mammalian tissues. While developmentally programmed WGD supports normal tissue regeneration, unscheduled WGD dri...
MAN1A1 promotes colorectal cancer liver metastasis by maintaining TGFBR2 protein stability [0.03%]
MAN1A1通过维持TGFBR2蛋白稳定性促进结直肠癌肝转移
Yingxi Hu,Yinwen Xu,Kai Chen et al.
Yingxi Hu et al.
Emerging biochemical and genetic evidence has firmly established aberrant protein glycosylation as a critical regulator of oncogenic transformation, with glycocalyx remodeling profoundly influencing tumor microenvironment dynamics and metas...
MSCs attenuate airway remodeling in HDM-induced asthma by inhibiting the Timp1-Wnt2b axis [0.03%]
间充质干细胞通过抑制Timp1-Wnt2b轴抑制HDM诱导的小鼠哮喘气道重塑
Kai Yu,Xinyu Feng,Rong Zhang et al.
Kai Yu et al.
MSCs have demonstrated their unique therapeutic potential in early clinical trials for a variety of respiratory diseases in recent years, but their use in the treatment of asthma has rarely been reported. In this study, a chronic murine ast...