Targeting the Spata13-TGFβRI interaction inhibits infection-driven capsular contracture via suppression of fibroblast activation [0.03%]
靶向Spata13-TGFβRI相互作用通过抑制成纤维细胞活化来抑制感染驱动的包囊收缩
Yiyin Tang,Jiaqian Liao,Qi Tang et al.
Yiyin Tang et al.
Capsular contracture, a common complication following breast implant surgery, is driven by fibroblast-to-myofibroblast transition and excessive collagen deposition. Although bacterial biofilm and TGF-β signaling are implicated, the molecul...
Inhibition of KDM5A alleviates ferroptosis in myocardial infarction via the GDF15-GPX4 axis [0.03%]
通过GDF15-GPX4轴抑制KDM5A可缓解心肌梗死引起的铁死亡
Wenzhao Wei,Ming Zhou,Jiacheng Yue et al.
Wenzhao Wei et al.
Myocardial infarction (MI) is an acute cardiovascular condition with a poor prognosis, imposing substantial disease and economic burdens worldwide. The histone demethylase KDM5A is known to respond to oxygen levels; however, its role in MI ...
Sulforaphane promotes mammary epithelial cell proliferation in Xizang sheep by increasing FOXM1 and PI3K-Akt signaling [0.03%]
硫代葡萄糖苷代谢物吲哚-3-甲醇通过FOXM1和PI3K-Akt信号促进西藏绵羊乳腺上皮细胞增殖
Zhenzhen Zhang,Tingxian Chen,Yangzong Zhaxi et al.
Zhenzhen Zhang et al.
Mammary epithelial cells (MECs) are crucial for milk synthesis and secretion, and their abundance and activity directly influence milk yield and quality. This study investigates the effects of sulforaphane (SFN) on MECs isolated from Xizang...
Synergistic hepatic metabolic effects induced by coexposure to the fungicides carbendazim and procymidone in rats [0.03%]
杀真菌剂卡巴肼和(proc)氰菌胺协同暴露对大鼠肝脏代谢的影响
Zhiwei Bao,Ting Luo,Shiyi Hu et al.
Zhiwei Bao et al.
Carbendazim (CBZ) and procymidone (PRO) are two fungicides widely used for decades. With excessive use, potential public health risks from their coresidues in vegetables and the environment have attracted increasing attention. Here, 6-week-...
CCAR2 reduces the number of osteoclasts by controlling osteoclast apoptosis [0.03%]
CCAR2通过控制破骨细胞凋亡减少破骨细胞数量
Junyue Zhang,Yiping Song,Si Chen et al.
Junyue Zhang et al.
Estrogen-associated signals regulating osteoclast apoptosis control osteoclast numbers. Enhancing anti-apoptotic activity during M-CSF and RANKL stimulation, which promotes osteoclast differentiation, increases the number of osteoclasts. Ce...
MAL2 drives hepatocellular carcinoma progression by recruiting regulatory T cells via CCL22 and inducing the immunosuppressive microenvironment [0.03%]
MAL2通过CCL22招募调节性T细胞并诱导免疫抑制微环境从而促进肝癌进展
Qian Zhang,Xiaowei Sun,Lantian Zhang et al.
Qian Zhang et al.
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, necessitating the identification of novel therapeutic targets. The transmembrane protein MAL2 has been implicated in various cancers, but its func...
USP18-stabilized ELF3 drives glycolysis and malignant progression in lung adenocarcinoma [0.03%]
USP18稳定ELF3促进肺腺癌的糖酵解和恶性进展
Yu Zeng,Yeran Yi,Qinfen Zhang et al.
Yu Zeng et al.
E74-like ETS transcription factor 3 (ELF3) has been implicated in various tumorigenesis and inflammatory diseases. However, its expression profile and role in lung adenocarcinoma (LUAD) remain poorly defined. In the present study, through c...
Targeting lactate with a GLUT1 inhibitor reverses PARP inhibitor resistance in ovarian cancer [0.03%]
靶向乳酸逆转卵巢癌PARP抑制剂耐药性
Shuqi Nie,Congli Pu,Hongyu Liu et al.
Shuqi Nie et al.
The widespread application of PARP inhibitors (PARPis) in epithelial ovarian cancer has led to the emergence of therapy resistance as a critical clinical challenge. To investigate the underlying mechanisms, we perform RNA sequencing of pair...
Inhibition of the cGAS-STING pathway mitigates liver injury induced by docetaxel-carboplatin neoadjuvant chemotherapy via autophagy promotion [0.03%]
cGAS-STING通路的抑制通过促进自噬减轻多西他赛-卡铂新辅助化疗诱导的肝损伤
Song Hu,Linghui Kong,Mo Chen et al.
Song Hu et al.
The docetaxel-carboplatin (TCb) combination is a widely used neoadjuvant chemotherapy regimen, yet its clinical application is frequently accompanied by hepatotoxicity and drug-induced liver injury (DILI). However, the underlying molecular ...
SGLT2 inhibitor dapagliflozin treats heart failure with preserved ejection fraction via the SIRT1/PGC-1α pathway [0.03%]
钠葡萄糖共转运体2抑制剂达格列净通过激活SIRT1/PGC-1α通路治疗射血分数保留的心力衰竭
Shiwen Zhang,Yansong Cui,Jingwen Chen et al.
Shiwen Zhang et al.
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have demonstrated clinical benefits in heart failure with preserved ejection fraction (HFpEF), yet the underlying mechanisms remain poorly defined. Given that mitochondrial dysfunction repr...