Roles and related underlying mechanisms of mitochondrial RNA modification in cancer progression [0.03%]
线粒体RNA修饰在癌症发生发展中的功能及其潜在机制
Ling-Zhi Wang,Tao-Yu Yang,Zi-Hui Xiong et al.
Ling-Zhi Wang et al.
Mitochondrial RNA modifications refer to modifications that occur across various RNA species within the mitochondria. While the incidence of such modifications is lower than that in the cytoplasm, substantial evidence highlights their pivot...
Serotonin receptor 4 in the ventral CA3 regulates agomelatine-induced anxiolytic-like behaviors [0.03%]
伏隔核外侧部分5-羟色胺受体4在阿戈美拉汀抗焦虑效应中的作用机制研究
Xiang-Hu Liu,Muhammad Naveed,Xiao-Yun Hu et al.
Xiang-Hu Liu et al.
Agomelatine, an atypical antidepressant, offers combined effects of sleep regulation, antidepressant action, and anxiolysis, making it particularly suitable for patients with insomnia and mood disorders. In this study, we investigated the m...
Graph-based deep learning approach for high-throughput protein-DNA interaction scoring [0.03%]
一种基于图的深度学习方法实现高通量蛋白质- DNA相互作用评分
Yi-Hao Zhao,Ying Wang,Chao Shen et al.
Yi-Hao Zhao et al.
Accurately quantifying protein-DNA interactions (PDIs) is critical for understanding biological processes and facilitating drug design. However, the inherent flexibility of nucleic acids limits the availability of experimentally determined ...
Adapter protein 2-modulated [Formula: see text] -opioid receptor trafficking in paraventricular thalamus contributes to fentanyl contextual addiction memory in mice [0.03%]
依赖美沙酮的小鼠在前腹侧丘脑中适应蛋白2调节的[公式见英文摘要]-阿片受体转位参与构建药物关联记忆形成过程中的重要作用
Yu-Jie Li,Ruo-Song Chen,Gui-Ying Zan et al.
Yu-Jie Li et al.
Fentanyl and its analogues are the most commonly used synthetic opioid analgesics in clinical practice, but their abuse is a significant concern. Drug-paired environmental cues often trigger memory retrieval, leading to relapse, complicatin...
Resibufogenin ameliorates cerebral ischemia-reperfusion injury by modulating microglial redox homeostasis via Keap1-Nrf2-TFR1/ARE axis [0.03%]
通过Keap1-Nrf2-TFR1 / ARE轴调节微胶质细胞氧化还原稳态可改善雷公藤红素引起的脑缺血再灌注损伤
Yao Chen,Wen-Qing Shi,Pei Zhang et al.
Yao Chen et al.
Cerebral ischemia-reperfusion injury (CIRI) represents a significant clinical challenge, with microglial homeostasis playing a critical role in its pathological progression. Venenum bufonis (VB) has been extensively utilized as a cardiotoni...
Mup3 ameliorates the dysregulation of glucose and lipid metabolism in MAFLD [0.03%]
Mup3改善MAFLD患者的葡萄糖和脂质代谢紊乱
Xiao-Min Zhang,Jing-Ya Gao,Dong Wang et al.
Xiao-Min Zhang et al.
Major urinary protein 3 (Mup3), belonging to the Mup family, is involved in metabolic regulation, but the exact regulatory pathways remain to be elucidated. In this study we investigated the function of Mup3 in regulating hepatic glucose an...
Magnolin overcomes EGFR TKI resistance in NSCLC by modulation of NDRG1-NRG2-HECW1 pathway [0.03%]
通过调节NDRG1-NRG2-HECW1途径克服非小细胞肺癌中表皮生长因子受体酪氨酸激酶抑制剂的耐药性
Qing Wu,Qi Su,Man Zhu et al.
Qing Wu et al.
Resistance of non-small cell lung cancer (NSCLC) to EGFR tyrosine kinase inhibitors (TKIs) limits the efficacy and leads to disease progression with mechanisms such as activation of autophagy in tumor cells, but the current therapeutic stra...
Correction: GluN2A-NMDA receptor inhibition disinhibits the prefrontal cortex, reduces forced swim immobility, and impairs sensorimotor gating [0.03%]
订正：GluN2A-NMDA受体抑制解除前额叶皮层的抑制，减少强迫游泳不动时间，并损害感觉运动门控功能
Yuan-Ping Dong,Yun Wu,Yi-Lu Zhao et al.
Yuan-Ping Dong et al.
Published Erratum
Acta pharmacologica Sinica. 2025 Nov 4. DOI:10.1038/s41401-025-01697-2 2025
Yue Zeng,Zhi-Yan Qu,Qian-Wen Zhu et al.
Yue Zeng et al.
N-methyl-D-aspartate (NMDA) receptors are glutamate-gated ion channels that are ubiquitously expressed throughout the central nervous system (CNS) and serve as crucial mediators of neural development and synaptic plasticity. Dysregulation o...
Formyl peptide receptor 2 is a potential biomarker and therapeutic target for inflammatory bowel disease [0.03%]
形式肽受体2是炎症性肠病的潜在生物标志物和治疗靶点
Wen-Sheng Yang,Xiao-Zhen Wang,Wei Wu et al.
Wen-Sheng Yang et al.
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is characterized by limited treatment options and a therapeutic ceiling. Failure to resolve inflammation is the key driver of disease progression....