Targeting the mitochondrial thermogenesis pathway for neuroprotection in neonatal hypoxic-ischemic encephalopathy by curcumin [0.03%]
姜黄素通过靶向线粒体生热通路对新生儿缺氧缺血性脑病进行神经保护作用
Xianxuan Wang,Bo Zhang,Sarah Eide et al.
Xianxuan Wang et al.
Neonatal hypoxic-ischemic (HI) brain injury remains a major cause of death and long-term neuro-disability leading to hypoxic-ischemic encephalopathy (HIE), and current hypothermia therapy is only partially effective. Curcumin is a polypheno...
The vascular niche: an orchestrator of the spatiotemporal dynamics of distant metastasis [0.03%]
血管生态位：远处转移时空动态的调控者
Qun Miao,Rong Chen,Dong-Mei Zhang et al.
Qun Miao et al.
Emerging evidence highlights that tumor metastasis is critically regulated by key dynamic vascular components, including endothelial cells (ECs) and pericytes, which engage in persistent intercellular crosstalk, both with one another and wi...
The multilevel exploration test, a novel paradigm to measure exploratory behavior in depression animal models and the involvement of the PL-ZI circuit [0.03%]
一种测量抑郁症模型中探究行为的新范式及其PL-ZI环路参与作用
Jun-Nan Xu,Jing-Ting Li,Ru-Xia Xu et al.
Jun-Nan Xu et al.
Diminished drive is one of the core symptoms of major depressive disorder (MDD) diagnosis, yet its underlying neural mechanisms remain elusive, primarily due to a lack of appropriate animal models. We developed a novel Multilevel Exploratio...
Targeting fusion proteins in solid tumors: from oncogenic mechanisms to clinical interventions [0.03%]
针对实体瘤融合蛋白的靶向治疗：从致癌机制到临床干预
Yue-Ning Yang,Yi-Fan Chen,Dong-Liang Yang et al.
Yue-Ning Yang et al.
Fusion proteins are implicated in a wide range of solid tumors, including lung cancer, breast cancer, and prostate cancer, and play a critical role in tumor initiation and progression through diverse molecular mechanisms. In this review, we...
Solute carrier transporters as metabolic gatekeepers in tumor-microenvironment crosstalk [0.03%]
溶质载体转运蛋白在肿瘤微环境互作中的代谢守门员作用
Zi-Han Zhang,Zi-Yi Ding,Luo-Yi Chen et al.
Zi-Han Zhang et al.
The tumor microenvironment (TME) is a metabolically dynamic niche characterized by active metabolic crosstalk between tumor cells and various stromal and immune cell subsets, which critically influences tumor progression and therapeutic out...
Correction: Magnolin overcomes EGFR TKI resistance in NSCLC by modulation of NDRG1-NRG2-HECW1 pathway [0.03%]
纠正：通过调节NDRG1-NRG2-HECW1通路克服NSCLC中EGFR TKI耐药性的Magnolin
Qing Wu,Qi Su,Man Zhu et al.
Qing Wu et al.
Published Erratum
Acta pharmacologica Sinica. 2026 May 18. DOI:10.1038/s41401-026-01837-2 2026
Correction: Inhibition of AXL enhances chemosensitivity of human ovarian cancer cells to cisplatin via decreasing glycolysis [0.03%]
纠正：AXL的抑制通过减少糖酵解增强人卵巢癌细胞对顺铂的化学敏感性
Min Tian,Xi-Sha Chen,Lan-Ya Li et al.
Min Tian et al.
Published Erratum
Acta pharmacologica Sinica. 2026 May 18. DOI:10.1038/s41401-026-01798-6 2026
Cell-based cancer immunotherapy: milestones, mechanistic insights, and emerging therapeutic directions [0.03%]
基于细胞的癌症免疫疗法：里程碑、机制见解和新兴治疗方向
Ji-Zhao Cao,Wei Zhao,Xiao-Jun Xia
Ji-Zhao Cao
Cell-based immunotherapies have emerged as a transformative modality in modern cancer treatment, complementing conventional approaches such as surgery, chemotherapy, radiotherapy, and molecularly targeted therapies. This review provides an ...
USP22 deubiquitinates and stabilizes ERK1/2 to promote colorectal cancer progression [0.03%]
USP22通过去泛素化和稳定ERK1/2促进结直肠癌进展
Guang-Chao Ma,Hai-Tao Yang,Gang Xu et al.
Guang-Chao Ma et al.
Extracellular signal-regulated kinase 1/2 (ERK1/2), a key effector involved in cell proliferation, differentiation, and apoptosis, is frequently dysregulated in colorectal cancer (CRC) tumorigenesis and confers extensive therapeutic resista...
Jia-Yi Liu,Dong-Liang Yang,Hai-Yan Liu et al.
Jia-Yi Liu et al.
Pediatric tumors represent a major cause of disease-related mortality in children and exhibit biological features that differ markedly from those of adult cancers. Pediatric malignancies display unique molecular architectures, with lower mu...