S1UTRSP5, a short restructured RNA from SLIT1 3'UTR, mitigates mouse cardiac remodeling via enhancing SlRT1 activity [0.03%]
SLIT1 3'UTR来源的短重构RNA S1UTRSP5通过增强Slit1活性抑制小鼠心脏重塑
Jin-Feng Su,Tao Ou,Xiao-Yao Liu et al.
Jin-Feng Su et al.
The 3' untranslated regions (3'UTRs) have been known to regulate mRNA location, stability, and translation. 3'UTR length regulation is involved in the pathogenesis of cardiac dysfunction; however, more about the roles of 3'UTRs in cardiac r...
Serum/glucocorticoid-regulated kinase 1 regulates vascular inflammation in atherosclerosis [0.03%]
血清/糖皮质激素调节激酶1在动脉粥样硬化血管炎症中的作用
Yang-Xian Li,Shu-Xiang Ding,Hui-Ling Hong et al.
Yang-Xian Li et al.
Endothelial and macrophage inflammation and sterol transport play an important role in atherogenesis. Serum/glucocorticoid-regulated kinase 1 (SGK1) is a member of the serine/threonine kinase family sharing approximately 54% identity with A...
Time-resolved proteomic and phosphoproteomic analysis reveals convergent and divergent biological perturbations induced by FDA-approved CDK4/6 inhibitors in hormone receptor-positive breast cancers [0.03%]
FDA批准的CDK4/6抑制剂在激素受体阳性乳腺癌中诱导的生物学扰动的时resolved蛋白质组和磷酸化蛋白质组分析揭示了不同和汇聚效应
Shi-Yu Duan,Lin-Hui Zhai,Wei Zhang et al.
Shi-Yu Duan et al.
Palbociclib, ribociclib, and abemaciclib, which are FDA-approved CDK4/6 inhibitors, constitute the standard first-line treatment for advanced hormone receptor-positive (HR+) breast cancers. Although these drugs share nominal targets and dem...
Repurposing atorvastatin for uterine leiomyosarcoma: mevalonate pathway inhibition yields preclinical antitumor efficacy [0.03%]
阿托伐他汀重定位用于子宫平滑肌肉瘤：梅瓦隆酸通路抑制产生抗肿瘤效应
Fang-Liang Zhou,Yi-Bin Wu,Wen Wang et al.
Fang-Liang Zhou et al.
Uterine leiomyosarcoma (ULMS) is a rare yet aggressive uterine malignancy with high recurrence and poor survival, prompting an urgent search for better treatments. We investigated whether atorvastatin, an HMG-CoA reductase inhibitor, could ...
Metabolic checkpoint blockade of IL4I1 by ZY-MY-111 reactivates CD8+ T cell immunity and suppresses tumor growth [0.03%]
代谢检查点抑制剂ZY-MY-111阻断IL4I1并重新激活CD8+T细胞免疫从而抑制肿瘤生长
Ju-Fei Li,Hao Wang,Ling Kang et al.
Ju-Fei Li et al.
Metabolic hijacking of tryptophan (Trp) via the IL4I1-AHR axis is a pivotal immune evasion mechanism in cancers, yet therapeutic strategies to disrupt this pathway remain unexplored. Here, we report the identification of ZY-MY-111, a select...
ApoE impairs microglial efferocytosis by targeting Gas6/MerTK in a mouse model of acute seizure [0.03%]
APOE通过靶向Gas6/MerTK损害急性癫痫小鼠模型的小胶质细胞胞葬作用
Bo Gao,Si-Min Cheng,Yu-Yan Zhang et al.
Bo Gao et al.
Epilepsy, a neurological condition, is characterized by frequent, spontaneous seizures. Both apolipoprotein E (ApoE) and TAM (Tyro3, Axl and MerTK) receptors, the key efferocytosis receptors, have been associated with the pathological mecha...
Echoes in the powerhouse: mito-lncRNAs contribution to cardiac function and disease [0.03%]
线粒体长链非编码RNA对心脏功能和疾病的影响
Abdallah Iddy Chaurembo,Na Xing,Zi-Feng Huang et al.
Abdallah Iddy Chaurembo et al.
Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide, and its progression is closely linked to mitochondrial dysfunction in cardiomyocytes. Given the high energy demands of the heart, precise regulatio...
Discovery of a novel dual-target modulator of ULK1 and ERK1/2 that suppresses triple-negative breast cancer progression and metastasis via the Exo70/Cav-1/MMPs axis [0.03%]
一种新型ULK1和ERK1/2双靶点调节剂通过Exo70/Cav-1/MMPs轴抑制三阴性乳腺癌进展和转移的发现
Min-Ru Liao,Yi Wang,Zhi-Chao Fan et al.
Min-Ru Liao et al.
Triple-negative breast cancer (TNBC) represents an aggressive breast cancer subtype with unfavorable clinical outcomes. Because actionable therapeutic targets remain limited, current treatment options are suboptimal and patient prognosis is...
Activation of peripheral muscarinic receptors rescues depressive-like behaviors via gut-brain-axis, involving parasympathetic excitation [0.03%]
外周胆碱能受体激活通过肠-脑轴介导的副交感神经兴奋缓解抑郁样行为
Fang-Fang Gao,Yi-Fan Xu,Jing Zhang et al.
Fang-Fang Gao et al.
Dysfunction of the autonomic nervous system (ANS) is strongly linked to the pathophysiological mechanisms of depression. Unfortunately, the correlation between depressive-like behaviors and the activation or inhibition of the sympathetic/pa...
The solute carrier transporter SLCO5A1 as a novel therapeutic target for the treatment of myocardial infarction-induced heart failure [0.03%]
缺血性心力衰竭治疗的新药物靶点SLCO5A1蛋白质
Ke-Yu Liu,Ke Gong,Fang Fang et al.
Ke-Yu Liu et al.
Heart failure (HF) following myocardial infarction (MI) remains a major threat to health worldwide. While transcriptomics has revealed numerous genes whose expression is altered in HF, distinguishing therapeutic targets remains challenging....