Development of XYD113 as a potent and highly selective GSPT1 degrader for cancer therapy [0.03%]
XYD113的开发作为一种有效的GSPT1降解剂用于癌症治疗
Hui Shen,Xiao-Yu Luo,Xin-Yi Jing et al.
Hui Shen et al.
G1 to S phase transition 1 (GSPT1) represents a promising yet historically challenging therapeutic target for MYC-driven malignancies. Herein, we identified XYD113, a potent and highly selective GSPT1-targeting molecular glue degrader. XYD1...
Sweetening the bonds: how O-GlcNAcylation modulates cell adhesion [0.03%]
增添甜蜜：O-GlcNAcylation如何调节细胞黏附
Wen-Hui Lou,Guo-Hong Qiao,Zi-Jun Wei et al.
Wen-Hui Lou et al.
O-GlcNAcylation is a dynamic, reversible post-translational modification that attaches N-acetylglucosamine (GlcNAc) to the serine or threonine residues of intracellular proteins. Catalysed by O-GlcNAc transferase and removed by O-GlcNAcase,...
Fibroblast growth factors in ischemic stroke: Therapeutic potential and clinical challenges [0.03%]
缺血性卒中中的成纤维细胞生长因子：治疗潜力与临床挑战
Confidence Dordoe,Kai-Ming Guo,Canol Bwalya et al.
Confidence Dordoe et al.
Ischemic stroke is a leading cause of global mortality and long-term disability, with limited therapeutic options. Increasing evidence from experimental studies suggests that fibroblast growth factors (FGFs) play important roles in regulati...
A dual-antigen mRNA-lipid polyplex vaccine elicits durable multistage immunity and sterile protection against malaria in mice [0.03%]
一种双抗原mRNA-脂质聚复合物疫苗能够诱导持久的多阶段免疫并使小鼠免受疟疾感染
Xiaoxing Wang,Aiai Wang,Wenqi Huang et al.
Xiaoxing Wang et al.
Malaria remains one of the most devastating infectious diseases worldwide, predominantly caused by Plasmodium falciparum. Although the RTS,S and R21 vaccines have demonstrated partial efficacy, durable and broad protection across multiple p...
DNMT1-mediated central amygdala to locus coeruleus circuit contributes to chronic pain-related depression in mice [0.03%]
DNA甲基转移酶1介导的中央杏仁核至蓝斑环路参与小鼠慢性痛抑郁状态形成
Xiao-Bao Ding,Xin-Yu Li,Yi-Yuan Zhang et al.
Xiao-Bao Ding et al.
Chronic pain has emerged as the third leading health issue, following cardiovascular and cerebrovascular diseases and cancer. Clinically, patients with chronic pain often exhibit comorbid depression-like behaviors. However, the underlying m...
Sevoflurane-induced disruption of critical period Arc signaling drives aberrant microglial synaptic pruning and cognitive deficits [0.03%]
异氟醚诱导的关键期弧蛋白信号紊乱导致异常的小胶质细胞突触修剪和认知障碍
Bai-Hui Chen,Ye-Ru Chen,Liang-Yu Zheng et al.
Bai-Hui Chen et al.
Early-life sevoflurane exposure is associated with long-term cognitive deficits. Given that hippocampal development relies on precise critical windows, disruption of developmental processes during these periods is likely the origin of these...
Amyloid-beta fibrils as active contributors to synaptic dysfunction in Alzheimer's disease [0.03%]
淀粉样蛋白纤维在阿尔茨海默病中作为突触功能障碍的活性贡献者的作用
Nunzia Maisto,Giorgia Ciufolini,Sepideh Dashtiani et al.
Nunzia Maisto et al.
Alzheimer's disease (AD) is a neurodegenerative disorder that is characterized by the accumulation of amyloid-beta (Aβ) aggregates, in the form of fibrils and plaques. While it has largely been stated that Aβ oligomers are the main toxic ...
Epigenetic plasticity in cancer drug resistance: mechanistic insights and strategies for therapeutic intervention [0.03%]
癌症药物耐药的表观遗传可塑性：机制见解和治疗干预策略
Wei Zhao,Jing-Xuan Pan
Wei Zhao
Therapy resistance remains a central barrier to durable clinical benefit across cancer types, limiting the long-term efficacy of chemotherapy, targeted therapies, and immunotherapy. Although genetic alterations contribute to resistance, inc...
METTL3 loss exacerbates colitis via m6A-dependent Slc39a8 regulation and epithelial lineage depletion [0.03%]
METTL3缺失通过m6A依赖的Slc39a8调控和上皮细胞谱系耗竭加重结肠炎
Hao Su,De-Hua Liu,Hai-Yun Shang et al.
Hao Su et al.
The intestinal epithelium maintains host-microbiota homeostasis, while inflammatory conditions, such as inflammatory bowel disease (IBD), induce pathological shifts in intestinal epithelial cell (IEC) subtypes. We unveil METTL3, an RNA m6A ...
Paclitaxel prodrug loaded high-density lipoprotein nanoparticles for chemoimmunotherapy of triple-negative breast cancer [0.03%]
用于三阴性乳腺癌化疗免疫治疗的紫杉醇前药载高密度脂蛋白纳米粒
Lin-Yang Jiang,Bin-Yu Zhu,Ling-Li Zhou et al.
Lin-Yang Jiang et al.
Insufficient tumor-specific immunogenicity and cytotoxic T lymphocytes infiltration limit the therapeutic efficacy of combined chemotherapy and immune checkpoint blockade for triple-negative breast cancer (TNBC). To address this limitation,...