PXR ribosylation at E194 amplifies NAPQI in acetaminophen‒induced liver injury in mice, rescued by Schisandrin B [0.03%]
匹罗卡品致小鼠肝损伤中PXR依赖的阿司匹林偶氮酚增敏作用及光学香豆素B对其的保护作用
Jia-Chan Long,Chen-Xu Liu,Meng-Yao Wang et al.
Jia-Chan Long et al.
Acetaminophen (APAP)-induced acute liver injury (AILI) is primarily driven by CYP3A4‒mediated overproduction of the toxic metabolite N-acetyl-p-benzoquinone imine (NAPQI), CYP3A4 activity serves as the rate-limiting determinant of NAPQI ac...
HDAC inhibitor GCJ-490A modulates tumor microenvironment and synergizes with PD-1 antibody against breast and lung cancers in syngeneic murine models [0.03%]
组蛋白去乙酰化酶抑制剂GCJ-490A调节肿瘤微环境并与PD-1抗体协同作用对抗同基因鼠乳腺癌和肺癌模型研究
Wen-Xin Zhang,Ting He,Kun Fang et al.
Wen-Xin Zhang et al.
Histone deacetylases (HDAC) inhibition represents one of the few validated strategies in epigenetic cancer therapies, demonstrating significant clinical efficacy in T-cell lymphomas and multiple myeloma, yet exhibiting limited efficacy agai...
HDAC3 mediates retinal endothelial cell metabolic reprogramming and angiogenesis [0.03%]
组蛋白脱乙酰酶3介导视网膜内皮细胞代谢重构和血管生成
Christian D Mitchell,Carol A Morris,Melissa Wild et al.
Christian D Mitchell et al.
Pathological retinal neovascularization (NV) contributes to vision loss in diabetic retinopathy (DR) and retinopathy of prematurity, which are the leading causes of blindness in working-age adults and children, respectively. Retinal hypoxia...
Editorial Expression of Concern: n-Butylidenephthalide induced apoptosis in the A549 human lung adenocarcinoma cell line by coupled down-regulation of AP-2α and telomerase activity [0.03%]
撤稿声明：n-丁基苯并菲诱导A549人肺腺癌细胞系凋亡耦合下调AP-2α和端粒酶活性
Chyou-Wei Wei,Chai-Ching Lin,Yung-Luen Yu et al.
Chyou-Wei Wei et al.
TNFSF15 alleviates myeloid-derived suppressor cell-mediated cancer immunosuppression in mice [0.03%]
TNFSF15通过抑制小鼠骨髓源性抑制细胞介导的免疫抑制发挥抗肿瘤作用
Yi-Pan Zhu,Jing Sun,Xin-Yu Cao et al.
Yi-Pan Zhu et al.
Myeloid-derived suppressor cells (MDSCs) are a category of immature myeloid cells that have an important function in suppressing immune responses in a variety of pathological settings. Thus, MDSCs are the subject of intensive studies regard...
Correction: magnesium isoglycyrrhizinate ameliorates high fructose-induced liver fibrosis in rat by increasing miR-375-3p to suppress JAK2/STAT3 pathway and TGF-β1/Smad signaling [0.03%]
纠正：镁异甘草酸通过增加miR-375-3p来抑制JAK2/STAT3通路和TGF-β1/Smad信号传导，改善高果糖诱导的大鼠肝纤维化
Yan-Zi Yang,Xiao-Juan Zhao,Hong-Jiang Xu et al.
Yan-Zi Yang et al.
Published Erratum
Acta pharmacologica Sinica. 2025 Sep 18. DOI:10.1038/s41401-025-01656-x 2025
Species differences in the hepatobiliary disposition of morphine-6-glucuronide mediated by hepatic transporters in rats and humans [0.03%]
大鼠和人肝脏转运体介导的吗啡-6-葡萄糖醛酸胆汁排泄种属差异研究
Zi-Tao Guo,Hong Wang,Ning-Jie Xie et al.
Zi-Tao Guo et al.
Morphine-6-glucuronide (M6G), the active metabolite of morphine, is currently in clinical development due to its higher analgesic activity. In humans, intravenously administered M6G was predominantly eliminated unchanged through the kidney,...
Tigecycline suppresses colon cancer stem cells and impairs tumor engraftment by targeting SNAI1-regulated epithelial-mesenchymal transition [0.03%]
特拉 cycline通过靶向SNAI1调节的上皮间质转化来抑制结直肠癌干细胞并损害肿瘤植入
Antonio Jesús Ruiz-Malagón,María Jesús Rodríguez-Sojo,Jorge García-García et al.
Antonio Jesús Ruiz-Malagón et al.
Cancer stem cells (CSCs) play a key role in the progression of colorectal cancer (CRC). The high heterogeneity of CSCs has hindered the clinical application of CSC-targeting therapies. Tetracyclines are drugs with therapeutic potentials bey...
Fumarate hydratase ameliorates pressure overload induced cardiac remodeling by controlling Elovl7-mediated biosynthesis of unsaturated fatty acids [0.03%]
富马酸水合酶通过控制Elovl7介导的不饱和脂肪酸生物合成来缓解压力超负荷诱导的心脏重塑
Lan-Lan Li,Chao-Jun Sun,Xiao-Tong Mo et al.
Lan-Lan Li et al.
Pathological cardiac hypertrophy as a major contributor to heart failure is characterized by complicated mechanisms. Fumarate hydratase (FH) is a crucial enzyme in the tricarboxylic acid cycle. FH mutations and dysfunction have been implica...
Krüppel-like factor 15 ameliorates alcohol-induced liver injury in mice via regulation of the PFKFB3/AKT axis [0.03%]
Krüppel样转录因子15通过调节PFKFB3/AKT轴缓解酒精性肝损伤
Hao Chen,Lin Yang,Xiao-Feng Li et al.
Hao Chen et al.
Alcohol-associated liver disease (ALD) remains a predominant cause of chronic hepatic pathology, and effective therapeutic strategies are needed. Krüppel-like factor 15 (KLF15) is a member of the KLF family of zinc-finger transcription fac...