From calcium signaling to cardiovascular pharmacology: TRPM7 as a key mechanistic regulator and emerging pharmacological focus [0.03%]
从钙信号到心血管药理学：TRPM7是一个关键的机制调节因子和新兴的药理学焦点
Xin-Yang Zhang,Hio Lam Ho,Zhong-Ping Feng et al.
Xin-Yang Zhang et al.
Cardiovascular diseases remain the leading global cause of death and disability, prompting the need for precise mapping of molecular drivers that couple ionic flux to signaling. Because of its regulatory role in ionic balance and signaling,...
Alkalization of the intracellular pH reprograms TNF-α signaling from inflammatory NF-κB activation to tumoricidal RIP kinase-dependent necroptosis in cancer cells [0.03%]
细胞内pH碱化将TNF-α信号重编程为从炎症NF-κB激活到癌症细胞中的肿瘤杀伤型RIP激酶依赖性坏死作用
Chang Ying,Di Wang,Si-Ying Zeng et al.
Chang Ying et al.
Tumor necrosis factor-alpha (TNF-α) plays paradoxical roles in cancer, promoting tumor survival via NF-κB activation while also inducing necroptotic cell death. Here, we identify the intracellular pH (pHᵢ) as a decisive switch that repro...
Gut microbiota and renal fibrosis: novel mechanistic insights and therapeutic potential [0.03%]
肠道微生物群与肾纤维化：新的机制见解和治疗潜力
Li-Min Liu,Xiao-Fei He,Yu-Lu Zhang et al.
Li-Min Liu et al.
Kidney diseases, including acute kidney injury (AKI) and chronic kidney disease (CKD), are associated with changes in the composition and function of gut microbiota. Available evidence has delineated that both AKI and CKD were associated wi...
Nanobody-based targeted cancer therapy and immunotherapy: fear not the future [0.03%]
基于纳米抗体的靶向癌症治疗和免疫治疗：不必害怕未来
Ma-di Guo,Ran Liao,Meng-Yao Wang et al.
Ma-di Guo et al.
Advances in understanding tumor heterogeneity and the tumor microenvironment (TME) have ushered in a new era of targeted and immunotherapy. Both targeted and immunotherapy mainly rely on the use of specific antibodies against the tumor targ...
5-OH-TMT mitigates colitis through HTRA2 binding-mediated activation of the Dectin-1 signaling pathway [0.03%]
5-羟基-TMT通过HTRA2结合介导的Dectin-1信号通路活化缓解结肠炎
Chun-Xiu Xiao,Wen-Yuan Wu,Shi-Cong Li et al.
Chun-Xiu Xiao et al.
Inflammatory bowel disease (IBD) is a debilitating condition driven by the dual pathologies of chronic inflammation and impaired intestinal barrier function. A significant clinical need exists for therapies that can effectively target both ...
Fangchinoline restores TFEB-driven lysosomal biogenesis and blocks H1N1 infection [0.03%]
方氯碱恢复TFEB驱动的溶酶体生物合成并抑制甲型流感病毒感染
Cui-Qin Cheng,Fang Xie,Zhe Liu et al.
Cui-Qin Cheng et al.
Influenza A viruses subvert lysosomal function to evade host degradation mechanisms. Using Connectivity Map (CMap) screening and transcriptomic analysis, we identified fangchinoline (Fan)-a bisbenzylisoquinoline alkaloid-as a potent enhance...
A novel CDK8/19 inhibitor RO8323 mitigates allograft rejection through dual mechanisms of action to modulate regulatory T cell and myeloid cell [0.03%]
一种新型的CDK8/19抑制剂RO8323通过双重作用机制缓解同种异体移植排斥反应以调节调节性T细胞和髓系细胞
Fang Shen,Rou Xie,Ye Gan et al.
Fang Shen et al.
Regulatory T (Treg) cells are pivotal in maintaining immune homeostasis through suppression of effector T (Teff) cells, making their therapeutic modulation a promising strategy for treating autoimmune and inflammatory diseases. CDK8/19 inhi...
Transcutaneous allicin oleogel restores energy homeostasis for obesity treatment [0.03%]
透过皮肤的蒜素油凝胶可恢复能量稳态以治疗肥胖症
Quan-Gang Xu,Ze-Yun Gu,Wen-Jie Chen et al.
Quan-Gang Xu et al.
Allicin, a bioactive compound derived from garlic, exhibits therapeutic potential against metabolic disorders but is hindered by instability and a pungent odor, limiting its clinical application. This study develops an allicin oleogel (OG) ...
Piroctone olamine promotes BECN1 transcription and activates autophagy by targeting HDAC6 in colorectal cancer [0.03%]
皮洛克酮橄榄通过靶向结直肠癌中的HDAC6促进BECN1转录并激活自噬
Cui-Yun Cui,Qiu-Tong Li,Xiong-Yan Xiang et al.
Cui-Yun Cui et al.
Colorectal cancer (CRC) is a leading cause of cancer-related mortality, often diagnosed at advanced stages when treatment options are limited. Histone deacetylases (HDACs) are frequently overexpressed in CRC, promoting tumor cell proliferat...
Non-telomeric function deficiency of TERT enhances pressure overload-induced mouse cardiac remodeling by activation of CNBP-mediated THBS3/ITGB1 pathway [0.03%]
TERT端粒外功能缺乏通过激活CNBP介导的THBS3/ITGB1通路增强小鼠压力超负荷诱导的心脏重塑
Ying-Ying Liu,Ying-Chao Wang,Wen-Yan Gong et al.
Ying-Ying Liu et al.
Recent studies show that telomerase reverse transcriptase (TERT) possesses important new biological functions in gene transcription regulation, signal transduction, tumorigenesis, vascular development and mitochondrial DNA protection indepe...