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Fangchinoline restores TFEB-driven lysosomal biogenesis and blocks H1N1 infection

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Influenza A viruses subvert lysosomal function to evade host degradation mechanisms. Using Connectivity Map (CMap) screening and transcriptomic analysis, we identified fangchinoline (Fan)-a bisbenzylisoquinoline alkaloid-as a potent enhancer of lysosomal gene ... ...