A review on prognostic biomarker and phytocompound-mediated modulation of signaling pathways in colorectal cancer [0.03%]
结直肠癌预后生物标志物和植物化合物介导的信号通路调节的研究进展综述
Bhavyaa Krishnakumar,Benedict Christopher Paul,Sabina Evan Prince et al.
Bhavyaa Krishnakumar et al.
Primary objective: This review aims to summarize and synthesize current knowledge on prognostic biomarkers in colorectal cancer (CRC). Rationale: ...
MLH1 rs63749795 variant confers increased risk for endometriosis: a genetic association study [0.03%]
MLH1 Rs63749795变异增加子宫内膜异位症发病风险的遗传关联研究
Niloofar Nazarikhah,Mohammad Javad Mokhtari
Niloofar Nazarikhah
Aims: The present study aimed to investigate the association between two MutL homolog 1 (MLH1) single-nucleotide polymorphisms (SNPs), rs63749795 and rs63749820, and the risk of endometriosis. ...
Association of XRCC4 and XRCC5 gene polymorphisms with polycystic ovarian syndrome in an Indian cohort [0.03%]
XRCC4和XRCC5基因多态性与印度人群多囊卵巢综合征的关系研究
Nikitha Sridhar,Gayathri Venkatakrishnan,Jiby Jolly Benjamin et al.
Nikitha Sridhar et al.
Aim: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in Indian women, with prevalence influenced by ethnicity, lifestyle, and associated metabolic conditions. Given the emerging link between genomic instab...
OMICs data from Tunisian population: challenges and opportunities in the era of precision medicine [0.03%]
突尼斯人群的组学数据：精确医学时代的机遇与挑战
Chaima Hkimi,Hamza Yaiche,Selim Kamoun et al.
Chaima Hkimi et al.
Objective: The transition to precision medicine (PM) is revolutionizing healthcare by enabling diagnostics and treatments tailored to individual molecular and genetic profiles, with omics sciences at its core. In Tunisia,...
The association between DNA repair genes polymorphisms and cisplatin-induced ototoxicity in cancer patients: a systematic review [0.03%]
DNA修复基因多态性与顺铂引起的癌症患者耳毒性的关联：系统评价
Nabil E Omar,Rana Mekkawi,Salma Said et al.
Nabil E Omar et al.
Introduction: Ototoxicity is a dose-limiting toxicity of cisplatin. Several DNA repair gene polymorphisms have been investigated for their association with cisplatin-induced ototoxicity (CIO), but their predictive value r...
Lineage-specific transcriptomic signatures and therapeutic target discovery in myeloid and lymphoid leukemias [0.03%]
髓系和淋巴系白血病中的系别特异性转录特征及治疗靶点发现
Başak Özay,Onur Ateş,Yağmur Kiraz
Başak Özay
Aim: Leukemias are heterogenous hematologic malignancies broadly classified into myeloid and lymphoid lineages, each with distinct molecular and clinical features. Here we aime to identify lineage-specific molecular vulne...
A population pharmacokinetic model for early follow-up dosing of tacrolimus in Tunisian kidney transplant recipients [0.03%]
用于突尼斯肾移植受者的他克莫司早期随访剂量的群体药代动力学模型
Amani Abderahmene,Marith I Francke,Meriam Ammar et al.
Amani Abderahmene et al.
Introduction: Tacrolimus is the cornerstone of immunosuppressive therapy in kidney transplantation. However, it exhibits significant pharmacokinetic (PK) variability among patients. Therefore, Population Pharmacokinetic (...
Association between CYP11B2 rs1799998 genetic variant with essential hypertension and antihypertensive response [0.03%]
遗传多态性CYP11B2 rs1799998与原发性高血压及降压反应之间的关系分析
Dalia Abdelrazaq,Yazun Jarrar,Hussein Alhawari et al.
Dalia Abdelrazaq et al.
Background: Essential hypertension (EH) is influenced by genetic and environmental factors. The CYP11B2 gene, encoding aldosterone synthase, plays a major role in blood pressure regulation. This study investigated the ass...
Homozygous GBA1 p.T82I variant in type 1 Gaucher disease: clinical and biochemical characterization [0.03%]
GBA1 p.T82I纯合子变异型1型戈谢病的临床和生化特征
Selin Genc,Filiz Mercantepe,Fahri Bayram
Selin Genc
Background: Gaucher disease (GD) is the most common lysosomal storage disorder caused by biallelic pathogenic variants in GBA1, resulting in deficient β-glucocerebrosidase activity. Clinical characterization of rare GBA1...
The genetic association of IL-17A rs8193036 with the susceptibility to Alzheimer's disease [0.03%]
IL-17A基因多态性与阿尔茨海默病遗传易感性的相关性分析
Yanni Luo,Jinpeng Huang,Zhongcheng An et al.
Yanni Luo et al.
Aim: This study aims to validate the relevance of IL-17A rs8193036 polymorphisms in susceptibility to Alzheimer's disease. Materials and methods: ...