Promising pharmacogenetic targets for treating alcohol use disorder: evidence from preclinical models [0.03%]
治疗酒精使用障碍的药理遗传学靶点：来自前临床模型的证据
Jennifer A Rinker,Patrick J Mulholland
Jennifer A Rinker
Inherited genetic variants contribute to risk factors for developing an alcohol use disorder, and polymorphisms may inform precision medicine strategies for treating alcohol addiction. Targeting genetic mutations linked to alcohol phenotype...
The role of germline variants in chemotherapy outcome in brain tumors: a systematic review of pharmacogenetic studies [0.03%]
基因变异在脑肿瘤化疗效果中的作用：药物遗传学研究的系统性回顾
Marije J Klumpers,Marieke Jh Coenen,Corrie Em Gidding et al.
Marije J Klumpers et al.
Aim: This systematic review provides an overview of publications concerning pharmacogenetic research in pediatric patients with medulloblastoma and low-grade glioma. ...
Jürgen Brockmöller,Julia C Stingl
Jürgen Brockmöller
Institutional Profile: Pharmacogenomic research in R Stephanie Huang Laboratory [0.03%]
黄瑞珊实验室的药物基因组学研究
Paul Geeleher,Aritro Nath,Rong Stephanie Huang
Paul Geeleher
The Huang Lab was established in 2009 at the University of Chicago and has since been active in conducting pharmacogenomic research. Our laboratory's main research focus is translational pharmacogenomics with a particular interest in the ph...
In vivo characterization of CYP2D6*12, *29 and *84 using dextromethorphan as a probe drug: a case report [0.03%]
用右美沙芬作为探针药物的CYP2D6*12、*29和*84等位基因的体内特征分析：病例报告
Andrea Gaedigk,Greyson P Twist,Emily G Farrow et al.
Andrea Gaedigk et al.
CYP2D6*84 was first described in a Black South African subject, however, its function remains unknown. Astrolabe, a probabilistic scoring tool developed in our laboratory to call genotypes from whole genome sequence, identified CYP2D6*84 in...
Case Reports
Pharmacogenomics. 2017 Apr;18(5):427-431. DOI:10.2217/pgs-2016-0192 2017
Ugonma N Chukwueke,Priscilla K Brastianos
Ugonma N Chukwueke
CNS metastases have long been recognized as a common and late complication of systemic malignancies. They represent the most common tumor of the brain. As outcomes and overall survival improve with better tolerated and more durable response...
Christopher Yi Wen Chan,Boon Yiang Chua,Mythily Subramaniam et al.
Christopher Yi Wen Chan et al.
Aim: This study aims to assess the attitudes and opinions of clinicians practicing in psychiatry toward pharmacogenomic testing, and in so doing elicits possible barriers and risks to employ this technology in patient car...
Jacob T Brown,Seenae Eum,Edwin H Cook et al.
Jacob T Brown et al.
Autism spectrum disorder (ASD) is characterized by persistent deficits in social communication and interactions as well as restricted, repetitive behaviors and interests. Pharmacologic interventions are often needed to manage irritability, ...
Primary care providers' use of pharmacist support for delivery of pharmacogenetic testing [0.03%]
药师支持基层医疗提供者进行药物基因组检测的实施
Susanne B Haga,Rachel Mills,Jivan Moaddeb et al.
Susanne B Haga et al.
Aim: To investigate provider utilization of pharmacist support in the delivery of pharmacogenetic testing in a primary care setting. Methods: ...
Multicenter Study
Pharmacogenomics. 2017 Mar;18(4):359-367. DOI:10.2217/pgs-2016-0177 2017
Systematic screening for CYP3A4 genetic polymorphisms in a Han Chinese population [0.03%]
汉人人群CYP3A4基因多态性的系统筛查
Guo-Xin Hu,Da-Peng Dai,Hao Wang et al.
Guo-Xin Hu et al.
Aim: To systematically investigate the genetic polymorphisms of the CYP3A4 gene in a Han Chinese population. Materials & methods: The p...