Polymorphisms associated with etanercept response in moderate-to-severe plaque psoriasis [0.03%]
依那西普治疗中重度斑块状银屑病疗效相关的基因多态性分析
María C Ovejero-Benito,Rocío Prieto-Pérez,Mar Llamas-Velasco et al.
María C Ovejero-Benito et al.
Aim: Few studies have evaluated the influence of pharmacogenetics in psoriatic patients treated with etanercept. Materials & methods: W...
Observational Study
Pharmacogenomics. 2017 May;18(7):631-638. DOI:10.2217/pgs-2017-0014 2017
Sequencing the CYP2D6 gene: from variant allele discovery to clinical pharmacogenetic testing [0.03%]
CYP2D6基因测序：从变异等位基因发现到临床药物基因组学检测
Yao Yang,Mariana R Botton,Erick R Scott et al.
Yao Yang et al.
CYP2D6 is one of the most studied enzymes in the field of pharmacogenetics. The CYP2D6 gene is highly polymorphic with over 100 catalogued star (*) alleles, and clinical CYP2D6 testing is increasingly accessible and supported by practice gu...
Serum clomipramine and desmethylclomipramine levels in a CYP2C19 and CYP2D6 intermediate metabolizer [0.03%]
氯米帕明和去甲基氯米帕明在中等代谢能力的CYP2C19和CYP2D6个体中的血清浓度
Jacob T Brown,Mark Schneiderhan,Seenae Eum et al.
Jacob T Brown et al.
Pharmacogenetics within psychiatry has the potential to aid in the dose and selection of medications. A substantial number of psychiatric medications are metabolized through either of the highly polymorphic drug-metabolizing enzymes CYP2D6 ...
CYP450 genotype and aggressive behavior on selective serotonin reuptake inhibitors [0.03%]
CYP450基因型和五羟色胺再摄取抑制剂的攻击性行为之间的关系
Corine Ekhart,Maja Matic,Agnes Kant et al.
Corine Ekhart et al.
Aim: Genetic variants for selective serotonin reuptake inhibitor (SSRI) metabolizing enzymes have been hypothesized to be a risk factor for aggression as adverse drug effect of SSRIs. Our aim was to assess the possible in...
OCT1 genetic variants are associated with postoperative morphine-related adverse effects in children [0.03%]
遗传变异与儿童术后阿片类药物不良反应有关
Rajiv Balyan,Xue Zhang,Vidya Chidambaran et al.
Rajiv Balyan et al.
Aim: Large interindividual variability in morphine pharmacokinetics (PK) could contribute to variability in morphine analgesia and adverse events. Respiratory depression (RD) and postoperative nausea and vomiting (PONV) a...
Pharmacogenomics in pediatric acute lymphoblastic leukemia: promises and limitations [0.03%]
儿科急性淋巴细胞白血病的药物基因组学：前景与局限性
Zeina N Al-Mahayri,George P Patrinos,Bassam R Ali
Zeina N Al-Mahayri
Despite the significant advances achieved in pediatric acute lymphocytic leukemia (ALL) treatment, adverse side effects of drugs remain a challenging issue. Numerous ALL pharmacogenomic studies have been conducted to elucidate the predispos...
Pharmacogenetic analysis of hepatitis C virus related mixed cryoglobulinemia [0.03%]
丙型肝炎病毒感染相关混合性冷球蛋白血症的药物基因组学分析
Jessica Cusato,Lucio Boglione,Amedeo De Nicolò et al.
Jessica Cusato et al.
Aim: Mixed cryoglobulinemia (MC) is an extra hepatic hepatitis C virus related problem and different studies suggested genetics' role in predicting this complication. We evaluated the influence of SNPs in IL-28B, SLC29A1,...
Association of vitamin D pathway SNPs and clinical response to interferon in a cohort of HBeAg-negative patients [0.03%]
维生素D信号通路基因多态性与HBeAg阴性慢性乙型肝炎患者干扰素治疗疗效的关系
Jessica Cusato,Lucio Boglione,Amedeo De Nicolò et al.
Jessica Cusato et al.
Aim: Vitamin D modulates biological processes; an influence of vitamin D levels and genetic variants was identified concerning hepatitis B virus infection. We evaluated the role of some SNPs of vitamin D pathway genes in ...
GWAS analysis of treatment resistant schizophrenia: interaction effect of childhood trauma [0.03%]
难治性精神分裂症的遗传分析：童年创伤的交互作用效应
Arthur Koga,Ali Bani-Fatemi,Nuwan Hettige et al.
Arthur Koga et al.
Aims: In the current study, we aimed to compare the prevalence of adverse lifetime events in treatment resistant and non-treatment resistant schizophrenia in a genome-wide association study. ...