DNA variants in DHFR gene and response to treatment in children with childhood B ALL: revisited in AIEOP-BFM protocol [0.03%]
DHFR基因多态性与儿童B-ALL治疗疗效关系的Meta分析及AIEOP-BFM方案中汉族人群的验证研究
Francesco Ceppi,Vincent Gagné,Laurance Douyon et al.
Francesco Ceppi et al.
Aim: We have previously reported an association of dihydrofolate reductase promoter polymorphisms with reduced event-free survival in childhood acute lymphoblastic leukemia (ALL) patients treated with Dana Farber Cancer I...
Effect of genetic variation in UGT1A and ABCB1 on moxifloxacin pharmacokinetics in South African patients with tuberculosis [0.03%]
UGT1A和ABCB1基因多态性对南非结核病患者莫西沙星药代动力学的影响
Anushka Naidoo,Veron Ramsuran,Maxwell Chirehwa et al.
Anushka Naidoo et al.
Aim: We assessed the effect of genetic variability in UGT1A and ABCB1 genes on moxifloxacin pharmacokinetics. Methods: Genotypes for se...
Genetic variation in statin intolerance and a possible protective role for UGT1A1 [0.03%]
他汀类药物不耐受的遗传变异以及UGT1A1的可能保护作用
Maria Alice V Willrich,Erin J Kaleta,Sandra C Bryant et al.
Maria Alice V Willrich et al.
The etiology of statin intolerance is hypothesized to be due to genetic variants that impact statin disposition and clearance. We sought to determine whether genetic variants were associated to statin intolerance. The studied cohort consist...
Genome-wide scan identifies candidate loci related to remifentanil requirements during laparoscopic-assisted colectomy [0.03%]
全基因组扫描识别出与腹腔镜辅助回肠切除术期间雷米芬太尼需求有关的候选位点
Daisuke Nishizawa,Tsutomu Mieda,Miki Tsujita et al.
Daisuke Nishizawa et al.
Aim: Opioids are widely used as effective analgesics, but opioid sensitivity is well known to vary widely among individuals. We explored the genetic factors that contribute to individual differences in intraoperative opi...
NR3C1 gene polymorphisms are associated with steroid resistance in patients with primary nephrotic syndrome [0.03%]
NR3C1基因多态性与原发性肾病综合征患者糖皮质激素抵抗相关性研究
Jie Liu,Zan Wan,Qianqian Song et al.
Jie Liu et al.
Aim: The aim of this study was to investigate the role of SNPs of genes involved in the glucocorticoid pathway in the development of steroid resistance in patients with primary nephrotic syndrome. ...
Jessica Cusato,Sarah Allegra,Amedeo De Nicolò et al.
Jessica Cusato et al.
To date, antiretroviral therapy is highly effective in HIV-affected patients, but the individualization of such a life-long therapy may be advised. This review briefly summarizes the main factors involved in the potential personalization of...
Genetic variations of the xenoreceptors NR1I2 and NR1I3 and their effect on drug disposition and response variability [0.03%]
异种受体NR1I2和NR1I3的基因多态性及其对药物处置和反应差异的影响
Litaty Céphanoée Mbatchi,Jean-Paul Brouillet,Alexandre Evrard
Litaty Céphanoée Mbatchi
NR1I2 (PXR) and NR1I3 (CAR) are nuclear receptors that are classified as xenoreceptors. Upon activation by various xenobiotics, including marketed drugs, they regulate the transcription level of major drug-metabolizing enzymes and transport...
The future role of pharmacogenomics in anticancer agent-induced cardiovascular toxicity [0.03%]
药物基因组学在抗肿瘤药物诱导的心血管毒性中的未来作用
Tarek Magdy,Paul W Burridge
Tarek Magdy
Recent trends on the role of epigenomics, metabolomics and noncoding RNAs in rationalizing mood stabilizing treatment [0.03%]
表观基因组学、代谢组学和非编码RNA在 Mood稳定治疗中的作用的最新趋势
Claudia Pisanu,Theodora Katsila,George P Patrinos et al.
Claudia Pisanu et al.
Mood stabilizers are the cornerstone in treatment of mood disorders, but their use is characterized by high interindividual variability. This feature has stimulated intensive research to identify predictive biomarkers of response and disent...
Polymorphisms associated with adalimumab and infliximab response in moderate-to-severe plaque psoriasis [0.03%]
与中至重度斑块状银屑病患者对抗adalimumab和infliximab反应相关的多态性
María C Ovejero-Benito,Rocío Prieto-Pérez,Mar Llamas-Velasco et al.
María C Ovejero-Benito et al.
Aim: This study evaluated the influence of pharmacogenetics in psoriatic patients treated with adalimumab and/or infliximab. Materials & methods: ...
Observational Study
Pharmacogenomics. 2018 Jan;19(1):7-16. DOI:10.2217/pgs-2017-0143 2018