Genetic variations of the xenoreceptors NR1I2 and NR1I3 and their effect on drug disposition and response variability
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NR1I2 (PXR) and NR1I3 (CAR) are nuclear receptors that are classified as xenoreceptors. Upon activation by various xenobiotics, including marketed drugs, they regulate the transcription level of major drug-metabolizing enzymes and transporters and facilitate t... ...
