Prevalence of TPMT and NUDT15 diplotypes in Mexican children with B-cell acute lymphoblastic leukemia [0.03%]
墨西哥B细胞急性淋巴细胞白血病儿童中TPMT和NUDT15复合型的分布状况
Joaquin Garcia-Solorio,Carolina Molina-Garay,Víctor Jesús Sánchez-Martínez et al.
Joaquin Garcia-Solorio et al.
Objective: To characterize the allelic and diplotype variability of TPMT and NUDT15 in pediatric patients with B-cell acute lymphoblastic leukemia from the central-southern region of Mexico. ...
Association between SLCO1B1, apolipoprotein E and ABCG2 genes and lipid response to rosuvastatin: a meta-analysis [0.03%]
SLCO1B1，载脂蛋白E和ABCG2基因与Rosuvastatin降脂反应之间的关系：一项荟萃分析
Jianhai Li,Yongkun Deng,Yong Lai et al.
Jianhai Li et al.
Objective: To investigate the effects of SLCO1B1, apolipoprotein E (APOE) and ABCG2 gene polymorphisms on the lipid-modulating efficacy of rosuvastatin. M...
The role of pharmacogenomics and opioid prescribing for infants with surgical congenital heart disease [0.03%]
药理基因组学和阿片类药物的开具在患有先天性心脏病的婴儿中的作用
Rabab M Barq,Shadassa Ourshalimian,Simran Maggo et al.
Rabab M Barq et al.
Objectives: Pharmacogenomic (PGx) variants associated with opioid metabolism and reward pathways may influence pain response and risk of opioid dependence. Infants undergoing surgery routinely receive opioids, and prolong...
Nayla Kassab,Joseph Abourjeili,Mary Joe Eid et al.
Nayla Kassab et al.
Pharmacogenomics (PGx) is a scientific field that aims to understand how an individual's genetic code regulates drug metabolism and response. The response to many anesthetic drugs varies widely among patients due to many factors including, ...
NFIB rs28379954 does not affect CYP2D6-mediated metabolism of prototypical substrates, tamoxifen or solanidine [0.03%]
NFIB rs22379954 不影响典型底物他莫昔芬或索拉尼idine 的CYP2D6介导的代谢
Samantha Medwid,Ute I Schwarz,Richard B Kim
Samantha Medwid
Background: Cytochrome P450 2D6 (CYP2D6) is a highly polymorphic drug-metabolizing enzyme involved in the metabolism of many clinically important medications. CYP2D6 is affected by genetic variation as well as drug intera...
Pharmacogenetic testing versus standard prescribing of psychotropics for the treatment of severe mood disorders: A randomized controlled trial protocol [0.03%]
精神药理学基因检测与重度心境障碍的精神药物治疗的常规处方：一项随机对照试验方案
Malcolm Hopwood,Angela Komiti,Melanie Hurley et al.
Malcolm Hopwood et al.
Background: Major depressive disorder (MDD) and bipolar disorder (BD) are common, disabling conditions. Despite associated morbidity and premature mortality, current treatments have modest efficacy and response to treatme...
Effects of glutathione-S-transferase polymorphisms on intravenous busulfan in hematopoietic stem cell transplant patients: a meta-analysis [0.03%]
一项关于谷胱甘肽-S-转移酶多态性对造血干细胞移植患者静脉注射丁吡豆醇影响的荟萃分析
Bushra Salman,Intisar Al Riyami,Raya Al Maskari et al.
Bushra Salman et al.
Objective: This study examined the impact of glutathione-S-transferase polymorphisms (GSTA1, GSTM1, GSTP1, and GSTT1) on the area under the curve (AUC), clearance, veno-occlusive disease (VOD), and graft-versus-host disea...
Leveraging implementation science to enhance the adoption of DPYD testing [0.03%]
利用实施科学促进DPYD检测的采纳增强
Sony Tuteja,J Kevin Hicks,Larisa H Cavallari et al.
Sony Tuteja et al.
Pharmacogenomics-guided personalized medicine in a clinical setting: real-world data [0.03%]
临床环境中的药物基因组学引导的个性化医疗：真实世界的数据分析
Jiayi Liang,Lianne Brand,Rikje Ruiter et al.
Jiayi Liang et al.
Background: Pharmacogenetic testing plays a key role in personalized pharmacotherapy and improving treatment outcomes; however, its benefit in clinical hyperpolypharmacy (≥ 10 chronic drugs) remains uncertain. ...
No interaction between genetic variants and DNA methylation of the ferrochelatase gene in relation to antituberculosis drug-induced liver injury [0.03%]
血红素合成酶基因DNA甲基化状态与抗结核药肝损伤易感性的关系及两者之间的互作分析
Fei Wang,Meiling Zhang,Yu Wu et al.
Fei Wang et al.
Objective: The pathogenic mechanisms of antituberculosis drug-induced liver injury (AT-DILI) remain unclear. Isoniazid and rifampicin may lead to hepatic accumulation of protoporphyrin IX in which heme synthesis ferrochel...